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Cytokines, Chemokines, Inflammasomes, Myokines and Complement-Related Factors in Acute Kidney Injury

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Organ Crosstalk in Acute Kidney Injury

Abstract

In this chapter we summarize a number of details about the inflammatory response that occurs within the kidney following typical causes of acute kidney injury. The aforementioned inflammatory response includes the release of cytokines, chemokines, and myokines. It is crucial to understand the molecular signals released by necrotic cells, which result in the activation of the inflammasome. The inflammasome is a multi-protein complex expressed in various cells, including epithelial and endothelial cells, dendritic cells, monocytes/macrophages, and lymphocytes. In addition, the expression of proinflammatory proteins such as complement proteins mediated by resident and recruited cell populations is an important determinant of the phases of cell injury and together are key triggers of inflammation after acute tissue injury.

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Authors and Affiliations

  1. Basic and Biomedical Sciences, Universidad Simón Bolívar, Barranquilla, Colombia

    Eloina Del Carmen Zarate-Peñata & Ornella Fiorillo-Moreno

  2. College of Health Sciences, Medicine Program, Corporation University Rafael Nuñez, Cartagena, Colombia

    Catherine Meza-Torres

  3. Basic and Biomedical Sciences, Universidad Simón Bolívar, Barranquilla, Colombia

    Elkin Navarro-Quiroz

  4. Life Sciences Research Center, Universidad Simón Bolívar, Barranquilla, Colombia

    Elkin Navarro-Quiroz

  5. Fundación Universidad San Martin, School of Medicine, Puerto Colombia, Colombia

    Elkin Navarro-Quiroz

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  1. Eloina Del Carmen Zarate-Peñata
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  2. Ornella Fiorillo-Moreno
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  3. Catherine Meza-Torres
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  4. Elkin Navarro-Quiroz
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Correspondence to Elkin Navarro-Quiroz .

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  1. Nephrology Division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Carlos Guido Musso

  2. Grigore T. Popa University of Medicine, Iasi, Romania

    Adrian Covic

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Zarate-Peñata, E.D.C., Fiorillo-Moreno, O., Meza-Torres, C., Navarro-Quiroz, E. (2023). Cytokines, Chemokines, Inflammasomes, Myokines and Complement-Related Factors in Acute Kidney Injury. In: Musso, C.G., Covic, A. (eds) Organ Crosstalk in Acute Kidney Injury. Springer, Cham. https://doi.org/10.1007/978-3-031-36789-2_5

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