Skip to main content

Acute Kidney Injury and Organ Crosstalk in COVID-19

  • Chapter
  • First Online:
Organ Crosstalk in Acute Kidney Injury

Abstract

COVID-19 can affect many other organs in addition to the respiratory system, particularly the kidney, heart, digestive tract, blood, and nervous system. As for the kidney alterations, they vary depending on the specific type of reported renal affectation, including proteinuria, hematuria, acute kidney injury, and its combination. COVID-19 induced cytokines storm is a paradigmatic example of pathogenic crosstalk among different body organs, particularly between the lung and the kidneys.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. World Health Organization. New coronavirus. China. 2020.

    Google Scholar 

  2. Musso-Enz GM. Why was the SARS-COV epidemic (2002–2003) so rapidly contained while SARS-COV-2 easily spread since December 2019 and gave rise to the actual pandemic? Electron J Biomed. 2021;3:34–6.

    Google Scholar 

  3. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Naicker S, Yang CW, Hwang SJ, Liu BC, Chen JH, Jha V. The novel coronavirus 2019 epidemic and kidneys. Kidney Int. 2020;97(5):824–8. https://doi.org/10.1016/j.kint.2020.03.001.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Su H, Yang M, Wan C, et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020;98(1):219–27. https://doi.org/10.1016/j.kint.2020.04.003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Gabarre P, Dumas G, Dupont T, Darmon M, Azoulay E, Zafrani L. Acute kidney injury in critically ill patients with COVID-19. Intensive Care Med. 2020;46(7):1339–48. https://doi.org/10.1007/s00134-020-06153-9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Cheng Y, Luo R, Wang K, et al. Kidney impairment is associated with in-hospital death of COVID-19 patients. medRxiv. 2020:1–21. https://doi.org/10.1101/2020.02.18.20023242.

  8. Sang L, Chen S, Zheng X, et al. The incidence, risk factors and prognosis of acute kidney injury in severe and critically ill patients with COVID-19 in mainland China: a retrospective study. BMC pulmonary Med. 2020;20:1–10.

    Article  Google Scholar 

  9. Shafi ST. Covid-19 and acute kidney injury: recent updates. Pak J Kidney Dis. 2020;4(2):225–7.

    Google Scholar 

  10. Aroca-Martínez G, Musso CG, Avendaño-Echavez L, González-Torres H, Vélez-Verbel M, Chartouni-Narvaez S, Peña-Vargas W, Acosta-Hoyos A, Ferreyra L, Cadena-Bonfanti A. Impact of frailty and viral load on acute kidney injury evolution in patients affected by COVID-19. Saudi J Kidney Dis Transpl. 2021;32(5):1356–64.

    PubMed  Google Scholar 

  11. Aroca-Martínez G, Musso CG, Avendaño-Echavez L, Vélez-Verbel M, Chartouni-Narvaez S, Hernandez S, Hinojosa-Vidal MA, Espitaleta Z, Cadena-Bonfanti A. Differences between COVID-19-induced acute kidney injury and chronic kidney disease patients. J Bras Nefrol. 2022;44(2):155–63.

    PubMed  PubMed Central  Google Scholar 

  12. Avendaño-Echavez L, Musso CG. COVID-19 and acute kidney injury: current knowledge. Rev Colomb Nefrol. 2020;7(Supl 2):168–9.

    Google Scholar 

  13. Gondo-an K, Temel S, Baran Ketencio-lu B, Rabah B, Tutar N, Sungur M. Acute kidney injury in SARS-CoV-2 infected critically ill Patients Turkish. J Nephrol. 2020;29:185–9.

    Google Scholar 

  14. Chan L, Chaudhary K, Saha A, et al. On behalf of the Mount Sinai COVID informatics center (MSCIC). AKI in hospitalized patients with COVID-19. J Am Soc Nephrol. 2020;32:151. https://doi.org/10.1681/ASN.2020050615.

    Article  PubMed  PubMed Central  Google Scholar 

  15. King-Vela E, Muñoz J, Rico-Fontalvo J, et al. Acute kidney injury in Colombian patients with COVID-19 who received kidney support therapy with genius® 90 technology. J Clin Nephrol. 2020;4(3):056–60.

    Google Scholar 

  16. Cheng Y, Luo R, Wang K, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;97(5):829–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Meijers B, Hilbrands LB. The clinical characteristics of coronavirus-associated nephropathy. Nephrol Dial Transplant. 2020;35(8):1279–81.

    Article  CAS  PubMed  Google Scholar 

  18. Molina-Barragan AM, Pardo E, Galichon P, et al. SARS-COV2 renal impairment in critical care: A retrospective study of 42 cases—Kid COVID Study. J Clin Med. 2021;10(8):1571. https://doi.org/10.21203/rs.3.rs-64088/v1.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Golmai P, Larsen DVM, et al. Histopathologic and ultrastructural findings in postmortem kidney biopsy material in 12 patients with AKI and COVID-19. J Am Soc Nephrol. 2020;31:1944–7. https://doi.org/10.1681/ASN.2020050683.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Batlle D, Soler MJ, Sparks MA, et al. Acute kidney injury in COVID-19: emerging evidence of a distinct pathophysiology. J Am Soc Nephrol. 2020;31(7):1380–3. https://doi.org/10.1681/ASN.2020040419.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Sise ME, Baggett MV, Shepard JO, Stevens JS, Rhee EP. Case 17-2020: a 68-year-old man with Covid-19 and kidney acute injury. N Engl J Med. 2020;382(22):2147–56.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Hernandez-Arroyo CF, Varghese V, Mohamed MMB, Velez JCQ. Urinary sediment microscopy in acute kidney injury associated with COVID-19. Kidney360. 2020;1(8):819–23. https://doi.org/10.34067/KID.0003352020.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Pujadas E, Chaudhry F, McBride R, et al. SARS-CoV-2 viral load predicts COVID-19 mortality. Lancet. 2020;8(9):e70.

    CAS  Google Scholar 

  24. Khan S, Chen L, Yang CR, et al. Does SARS-CoV-2 Infect the Kidney? J Am Soc Nephrol. 2020;31:1–3. https://doi.org/10.1681/ASN.2020081229.

    Article  Google Scholar 

  25. Braun F, Huber T, Puelles V. Proximal tubular dysfunction in patients with COVID-19: what have we learnt so far? Kidney Int. 2020;98(5):1092–4. https://doi.org/10.1016/j.kint.2020.09.002.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Redant S, De Bels D, Honoré PM. Severe acute respiratory syndrome coronavirus-2-associated acute kidney injury: a narrative review focused upon pathophysiology. Crit Care Med. 2021;49(5):e533–40.

    Article  CAS  PubMed  Google Scholar 

  27. González C, Yama E, Yomayusa N, et al. Colombian consensus of experts on evidence-informed recommendations for the prevention, diagnosis and management of sars-cov-2/covid-19 acute kidney injury. Rev Colomb Nefrol. 2020;7(Supl.2):50–69. https://revistanefrologia.org/index.php/rcn/article/view/473.

    Google Scholar 

  28. Lee J, Silberzweig J, Akchurin O, et al. Characteristics of acute kidney injury in hospitalized COVID-19 patients in an urban Academic Medical Center. Clin J Am Soc Nephrol. 2021;16:1–3. https://doi.org/10.2215/CJN.07440520.

    Article  CAS  Google Scholar 

  29. Zhou F, Ting Y, Ronghui D, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Ruan Q, Yang K, Wang W, et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46:846–8. https://doi.org/10.1007/s00134-020-05991-x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Páramo Fernández J. Coagulación, Dímero D y COVID-19. Sociedad Española de Trombosis y Hemostasia (SETH). https://www.seth.es/index.php/noticias/noticias/noticias-de-la-seth/1588-coagulacion-dimero-d-y-covid-19.html.

  32. Pérez G. Coronavirus. Impacto cardiovascular Sociedad Interamericana de Cardiología http://www.siacardio.com/novedades/covid-19/coronavirus-y-su-impacto-cardiovascular/.

  33. Driggin E, Madhavan MV, Bikdeli B, Chuich T, Laracy J, Bondi-Zoccai G, Brown TS, Nigoghossian CD, Zidar DA, Haythe J, Brodie D, Beckman JA, Kirtane AJ, Stone GW, Krumholz HM, Parikh SA. Cardiovascular considerations for patients, health care workers, and health systems during the coronavirus disease 2019 (COVID-19) pandemic. J Am Coll Cardiol. 2020;75:2352. https://doi.org/10.1016/j.jacc.2020.03.031.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. 2020;71:762. https://doi.org/10.1093/cid/ciaa248.

    Article  CAS  PubMed  Google Scholar 

  35. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395:1033. https://doi.org/10.1016/S0140-6736(20)30628-0.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Taverna G, Di Francesco S, Borroni EM, Yiu D, Toniato E, Milanesi S, Chiriva-Internati M, Bresalier RS, Zanoni M, Vota P, Maffei D, Justich M, Grizzi F. The kidney, COVID-19, and the chemokine network: an intriguing trio. Int Urol Nephrol. 2021;53(1):97–104. https://doi.org/10.1007/s11255-020-02579-8.

    Article  CAS  PubMed  Google Scholar 

  37. Loganathan S, Kuppusamy M, Wankhar W, Gurugubelli KR, Mahadevappa VH, Lepcha L, Choudhary AK. Angiotensin-converting enzyme 2 (ACE2): COVID 19 gate way to multiple organ failure syndromes. Respir Physiol Neurobiol. 2021;283:103548. https://doi.org/10.1016/j.resp.2020.103548.

    Article  CAS  PubMed  Google Scholar 

  38. Hassanein M, Radhakrishnan Y, Sedor J, Vachharajani T, Vachharajani VT, Augustine J, Demirjian S, Thomas G. COVID-19 and the kidney. Cleve Clin J Med. 2020;87(10):619–31.

    Article  PubMed  Google Scholar 

  39. Saeedi Saravi SS, Barbagallo M, Reiner MF, Schmid HR, Rutishauser J, Beer JH. Acute kidney injury associated with COVID-19: a prognostic factor for pulmonary embolism or co-incidence? Eur Heart J. 2020;41(48):4601. https://doi.org/10.1093/eurheartj/ehaa637.

    Article  CAS  PubMed  Google Scholar 

  40. Vakili K, Fathi M, Pezeshgi A, Mohamadkhani A, Hajiesmaeili M, Rezaei-Tavirani M, Sayehmiri F. Critical complications of COVID-19: a descriptive meta-analysis study. Rev Cardiovasc Med. 2020;21(3):433–42. https://doi.org/10.31083/j.rcm.2020.03.129.

    Article  PubMed  Google Scholar 

  41. Sam Kant S, Menez SP, Hanouneh M, Fine DM, Crews DC, Brennan DC, Sperati CJ, Jaar BG. The COVID-19 nephrology compendium: AKI, CKD, ESKD and transplantation. BMC Nephrol. 2020;21:449. https://doi.org/10.1186/s12882-020-02112-0.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Carlos Guido Musso .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Juana, C., Musso-Enz, V.P., Musso-Enz, G.M., Aroca-Martinez, G., Musso, C.G. (2023). Acute Kidney Injury and Organ Crosstalk in COVID-19. In: Musso, C.G., Covic, A. (eds) Organ Crosstalk in Acute Kidney Injury. Springer, Cham. https://doi.org/10.1007/978-3-031-36789-2_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-36789-2_16

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-36788-5

  • Online ISBN: 978-3-031-36789-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics