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Renal Replacement Treatment, Blood Purification, and Crosstalk in Acute Kidney Injury

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Organ Crosstalk in Acute Kidney Injury

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Abstract

Patients with severe complications of acute kidney injury (AKI) and hemodynamic instability in the intensive care unit (ICU) require extrarenal purification therapy, and the best indication is continuous renal replacement therapy (CRRT). Patients with AKI and involvement of other distant organs have demonstrated crosstalk in the pathophysiology of multiple organ failure. Acute neurological injury (ANI) and brain edema; acute heart failure (AHF) and cardiorenal syndrome not responding to usual pharmacological treatment; acute liver injury (ALI) and hepatorenal syndrome which, in addition to extrarenal clearance, require liver detoxification; and finally, the hyperinflammation of the patient with septic shock and AKI deserves individualized attention and indication of CRRT that treats the pathophysiological crosstalk of both organs.

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Author information

Authors and Affiliations

  1. Nephrology Division, Clínica IMAT Oncomédica Auna, Montería, Colombia

    Manuel Soto-Doria

  2. Internal Medicine and Nephrology, Clinica La Carolina, Bogotá, Colombia

    Juan Pablo Cordoba

  3. Nephrology Division, Clínica de la Costa, Barranquilla, Colombia

    Gustavo Aroca-Martinez

  4. Facultad de Ciencias de la Salud, Universidad Simón Bolivar, Barranquilla, Colombia

    Gustavo Aroca-Martinez & Carlos Guido Musso

  5. Nephrology Division and Research Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Carlos Guido Musso

Authors
  1. Manuel Soto-Doria
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  2. Juan Pablo Cordoba
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  3. Gustavo Aroca-Martinez
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  4. Carlos Guido Musso
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Corresponding author

Correspondence to Carlos Guido Musso .

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Editors and Affiliations

  1. Nephrology Division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Carlos Guido Musso

  2. Grigore T. Popa University of Medicine, Iasi, Romania

    Adrian Covic

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Soto-Doria, M., Cordoba, J.P., Aroca-Martinez, G., Musso, C.G. (2023). Renal Replacement Treatment, Blood Purification, and Crosstalk in Acute Kidney Injury. In: Musso, C.G., Covic, A. (eds) Organ Crosstalk in Acute Kidney Injury. Springer, Cham. https://doi.org/10.1007/978-3-031-36789-2_15

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  • DOI: https://doi.org/10.1007/978-3-031-36789-2_15

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