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Kidney–Heart Crosstalk in Acute Kidney Injury

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Organ Crosstalk in Acute Kidney Injury

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Abstract

The heart and kidneys are closely related in such a manner that any modification in one of these organs has an effect on the other organ, establishing a bidirectional relationship.

This generates a circuit of perpetuation that serves to maintain cardiovascular and renal homeostasis. Nevertheless, this circuit of perpetuation may lead to an inefficient adaptation. Therefore, the established relationship between the organs serves to maintain homeostasis and may lead to organ damage.

From a pathophysiological point of view, hemodynamic mechanisms are not the only circuits that exist between heart and kidney diseases. The classic concept of the heart–kidney crosstalk considered hemodynamic and neurohumoral response, but in recent years, the inflammatory activation has been incorporated and the mediators that participate in this process have been described.

The better understanding of intervening processes may allow a better approximation to the pathophysiology and, therefore, to a better treatment of both conditions.

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Author information

Authors and Affiliations

  1. Heart Failure Unit, Institute of Cardiovascular Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    César Antonio Belziti

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  1. César Antonio Belziti
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Correspondence to César Antonio Belziti .

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Editors and Affiliations

  1. Nephrology Division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Carlos Guido Musso

  2. Grigore T. Popa University of Medicine, Iasi, Romania

    Adrian Covic

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Belziti, C.A. (2023). Kidney–Heart Crosstalk in Acute Kidney Injury. In: Musso, C.G., Covic, A. (eds) Organ Crosstalk in Acute Kidney Injury. Springer, Cham. https://doi.org/10.1007/978-3-031-36789-2_10

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  • DOI: https://doi.org/10.1007/978-3-031-36789-2_10

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