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The Epidemiology of Normal Pressure Hydrocephalus

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Normal Pressure Hydrocephalus

Abstract

Summarising accurate epidemiological data regarding normal pressure hydrocephalus (NPH) is a complex task: for example, defining NPH varies across guidelines, various methodological approaches are utilised, different populations are studied, clinical signs are sometimes difficult to distinguish from those of the normal ageing process, and radiological signs are not necessarily specific to NPH. It would thus be unwise to simplify the complex question of NPH epidemiology to a mean number as this would not reflect the diverse patient population, methods of patient selection, and data processing used by different authors. Taking into consideration the frequency of shunt surgery, NPH remains an underdiagnosed condition of potentially treatable dementia. Both the incidence and prevalence of NPH increase with age. NPH is probably more common among the male gender and shows interesting traits among specific patient populations. For future studies, a unified approach with standardised data recording and strict adherence to international guidelines is necessary.

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Abbreviations

AD:

Alzheimer’s disease

A-E guidelines:

American-European guidelines for NPH diagnostics

ICP:

Intracranial pressure

MRI:

Magnetic resonance imaging

NIS:

National inpatient sample

NPH:

Normal pressure hydrocephalus

iNPH:

Idiopathic normal pressure hydrocephalus

NIS:

Nationwide inpatient sample

PD:

Parkinson’s disease

References

  1. Relkin N, et al. Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery. 2005;57(3 Suppl):S4–16; discussion ii-v.

    Google Scholar 

  2. Andersson J, et al. Prevalence of idiopathic normal pressure hydrocephalus: a prospective, population-based study. PLoS ONE. 2019;14(5): e0217705.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ishikawa M. Guideline committe for idiopathic normal pressure hydrocephalus, JSoNPH Clinical guidelines for idiopathic normal pressure hydrocephalus. Neurol Med Chir (Tokyo). 2004;44(4):222–3.

    Google Scholar 

  4. Mori E, et al. Guidelines for management of idiopathic normal pressure hydrocephalus: second edition. Neurol Med Chir (Tokyo). 2012 ;52(11):775–809.

    Google Scholar 

  5. Nakajima M, et al. Guidelines for management of idiopathic normal pressure hydrocephalus (third edition): endorsed by the Japanese society of normal pressure hydrocephalus. Neurol Med Chir (Tokyo). 2021;61(2):63–97.

    Article  PubMed  Google Scholar 

  6. Martin-Laez R, et al. Incidence of idiopathic normal-pressure hydrocephalus in northern Spain. World Neurosurg. 2016;87:298–310.

    Article  PubMed  Google Scholar 

  7. Yoshino Y, et al. Risk of idiopathic normal pressure hydrocephalus in older inpatients with schizophrenia. Int Psychogeriatr. 2016;28(5):863–8.

    Article  PubMed  Google Scholar 

  8. Yoshino Y, et al. Prevalence of possible idiopathic normal pressure hydrocephalus in older inpatients with schizophrenia: a replication study. BMC Psychiatry. 2020;20(1):273.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Razay G, Wimmer M, Robertson I. Incidence, diagnostic criteria and outcome following ventriculoperitoneal shunting of idiopathic normal pressure hydrocephalus in a memory clinic population: a prospective observational cross-sectional and cohort study. BMJ Open. 2019;9(12): e028103.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Alvi MA, et al. Prevalence and trends in management of idiopathic normal pressure hydrocephalus in the United States: insights from the national inpatient sample. World Neurosurg. 2021;145:e38–52.

    Article  PubMed  Google Scholar 

  11. Ghaffari-Rafi A, et al. Inpatient diagnoses of idiopathic normal pressure hydrocephalus in the United States: demographic and socioeconomic disparities. J Neurol Sci. 2020;418: 117152.

    Article  PubMed  Google Scholar 

  12. Klassen BT, Ahlskog JE. Normal pressure hydrocephalus: how often does the diagnosis hold water? Neurology. 2011;77(12):1119–25.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Tisell M, Hoglund M, Wikkelso C. National and regional incidence of surgery for adult hydrocephalus in Sweden. Acta Neurol Scand. 2005;112(2):72–5.

    Article  CAS  PubMed  Google Scholar 

  14. Verghese J, et al. Epidemiology of gait disorders in community-residing older adults. J Am Geriatr Soc. 2006;54(2):255–61.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Milsom I, Gyhagen M. The prevalence of urinary incontinence. Climacteric. 2019;22(3):217–22.

    Article  CAS  PubMed  Google Scholar 

  16. Cao Q, et al. The prevalence of dementia: a systematic review and meta-analysis. J Alzheimers Dis. 2020;73(3):1157–66.

    Article  PubMed  Google Scholar 

  17. Jaraj D, et al. Prevalence of idiopathic normal-pressure hydrocephalus. Neurology. 2014;82(16):1449–54.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Nakashita S, et al. Clinical assessment and prevalence of parkinsonism in Japanese elderly people. Acta Neurol Scand. 2016;133(5):373–9.

    Article  CAS  PubMed  Google Scholar 

  19. Brean A, Eide PK. Prevalence of probable idiopathic normal pressure hydrocephalus in a Norwegian population. Acta Neurol Scand. 2008;118(1):48–53.

    Article  CAS  PubMed  Google Scholar 

  20. Pyykko OT, et al. Incidence, comorbidities, and mortality in idiopathic normal pressure hydrocephalus. World Neurosurg. 2018;112:e624–31.

    Article  PubMed  Google Scholar 

  21. Hiraoka K, Meguro K, Mori E. Prevalence of idiopathic normal-pressure hydrocephalus in the elderly population of a Japanese rural community. Neurol Med Chir (Tokyo). 2008;48(5):197–99;discussion 199–200.

    Google Scholar 

  22. Tanaka N, et al. Prevalence of possible idiopathic normal-pressure hydrocephalus in Japan: the Osaki-Tajiri project. Neuroepidemiology. 2009;32(3):171–5.

    Article  PubMed  Google Scholar 

  23. Iseki C, et al. Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM) in the elderly: a prospective study in a Japanese population. J Neurol Sci. 2009;277(1–2):54–7.

    Article  PubMed  Google Scholar 

  24. Iseki C, et al. Incidence of idiopathic normal pressure hydrocephalus (iNPH): a 10-year follow-up study of a rural community in Japan. J Neurol Sci. 2014;339(1–2):108–12.

    Article  PubMed  Google Scholar 

  25. Masi AT. Potential uses and limitations of hospital data in epidemiologic research. Am J Public Health Nations Health. 1965;55:658–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Thygesen LC, Ersboll AK. When the entire population is the sample: strengths and limitations in register-based epidemiology. Eur J Epidemiol. 2014;29(8):551–8.

    Article  PubMed  Google Scholar 

  27. Krauss JK, Halve B. Normal pressure hydrocephalus: survey on contemporary diagnostic algorithms and therapeutic decision-making in clinical practice. Acta Neurochir (Wien). 2004;146(4):379–88; discussion 388.

    Google Scholar 

  28. Bir SC, et al. Epidemiology of adult-onset hydrocephalus: institutional experience with 2001 patients. Neurosurg Focus. 2016;41(3):E5.

    Article  PubMed  Google Scholar 

  29. Kuriyama N, et al. Nationwide hospital-based survey of idiopathic normal pressure hydrocephalus in Japan: epidemiological and clinical characteristics. Brain Behav. 2017;7(3): e00635.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Lemcke J, et al. Nationwide incidence of normal pressure hydrocephalus (NPH) assessed by insurance claim data in Germany. Open Neurol J. 2016;10:15–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Isaacs AM, et al. Age-specific global epidemiology of hydrocephalus: systematic review, metanalysis and global birth surveillance. PLoS ONE. 2018;13(10): e0204926.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Zaccaria V, et al. A systematic review on the epidemiology of normal pressure hydrocephalus. Acta Neurol Scand. 2020;141(2):101–14.

    Article  PubMed  Google Scholar 

  33. Bech-Azeddine R, et al. Idiopathic normal-pressure hydrocephalus: evaluation and findings in a multidisciplinary memory clinic. Eur J Neurol. 2001;8(6):601–11.

    Article  CAS  PubMed  Google Scholar 

  34. Marmarou A, Young HF, Aygok GA. Estimated incidence of normal pressure hydrocephalus and shunt outcome in patients residing in assisted-living and extended-care facilities. Neurosurg Focus. 2007;22(4):E1.

    Article  PubMed  Google Scholar 

  35. Oike R, et al. Screening for idiopathic normal pressure hydrocephalus in the elderly after falls. Clin Neurol Neurosurg. 2021;205: 106635.

    Article  PubMed  Google Scholar 

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Correspondence to Vladimír Beneš 3rd .

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Táborský, J., Blažková, J., Beneš, V. (2023). The Epidemiology of Normal Pressure Hydrocephalus. In: Bradac, O. (eds) Normal Pressure Hydrocephalus. Springer, Cham. https://doi.org/10.1007/978-3-031-36522-5_4

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  • DOI: https://doi.org/10.1007/978-3-031-36522-5_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-36521-8

  • Online ISBN: 978-3-031-36522-5

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