Abstract
Acute viral infections are a common reason for admission to the Intensive Care Unit (ICU). Among them, human immunodeficiency virus (HIV), influenza, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and herpesviruses are most frequently reported in critically ill setting, leading to potential life-threatening complications. Although combined antiretroviral therapy (ART) and adequate medical care have substantially improved the prognosis of HIV infection, opportunistic infections and other complications may require organ support in the ICU. Vaccination strategies and improved specific therapy may improve the outcomes of SARS-CoV-2 and influenza infections, but the cornerstone of therapy remains supportive care of acute respiratory distress syndrome (ARDS). The herpesviruses family also plays an important role in the ICU, causing encephalitis, pneumonia, gastrointestinal involvement, and skin lesions. Immunosuppressed patients are more susceptible to complicated viral infections, and these viruses may reactivate in patients with a state of immunoparalysis, which is at higher risk of unfavorable outcomes. The aim of this chapter is to briefly characterize the most common viral infections in the ICU, their management, and treatment.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Deeks SG, Overbaugh J, Phillips A, Buchbinder S. HIV infection. Nat Rev Dis Prim. 2015;1(1):1–22.
Sterling TR, Chaisson RE. Manifestaciones clínicas generales de la infección por el virus de la inmunodeficiencia humana (incluidos el síndrome retroviral agudo y las enfermedades orales, cutáneas, renales, oculares, metabólicas y cardiacas). In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, Bennett Enfermedades infecciosas Principios y práctica, Chapter 122. 9th ed. España, S.L.U.: Elsevier; 2021. p. 1658–74.
Global HIV & AIDS statistics—fact sheet | UNAIDS [internet]. [cited 2022 Sep 23]. https://www.unaids.org/en/resources/fact-sheet
HIV—The Global Health Observatory [Internet]. [cited 2022 Sep 23]. https://www.who.int/data/gho/data/themes/hiv-aids
Branson BM, Owen SM, Wesolowski LG, Bennett B, Werner BG, Wroblewski KE, et al. Laboratory testing for the diagnosis of HIV infection: updated recommendations. Atlanta, GA: Centers for Disease Control and Prevention (U.S.); Association of Public Health Laboratories; National Center for HIV/AIDS, Viral Hepatitis, and TB Prevention (U.S.). Division of HIV/AIDS Prevention; 2014. [cited 2022 Sep 23]. https://stacks.cdc.gov/view/cdc/23447
Thompson MA, Horberg MA, Agwu AL, Colasanti JA, Jain MK, Short WR, et al. Primary care guidance for persons with human immunodeficiency virus: 2020 update by the HIV medicine Association of the Infectious Diseases Society of America. Clin Infect Dis. 2021;73(11):e3572–605.
Barbier F, Mer M, Szychowiak P, Miller RF, Mariotte É, Galicier L, et al. Management of HIV-infected patients in the intensive care unit. Intensive Care Med. 2020;46(2):329–42.
Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, et al. Influenza. Nat Rev Dis Prim. 2018;4(1):1–21.
Treanor JJ. Virus de la gripe (incluidas gripes aviar y porcina). In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, Bennett Enfermedades infecciosas Principios y práctica, Chapter 165. 9th ed. Elsevier España, S.L.U.; 2021. p. 2143–68.
Influenza (Seasonal)—Fact sheets [Internet]. World Health Organization (WHO). [cited 2022 Sep 24]. https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal).
Kwong JC, Schwartz KL, Campitelli MA, Chung H, Crowcroft NS, Karnauchow T, et al. Acute myocardial infarction after laboratory-confirmed influenza infection. N Engl J Med. 2018;378(4):345–53.
Tejada S, Jansson M, Solé-Lleonart C, Rello J. Neuraminidase inhibitors are effective and safe in reducing influenza complications: meta-analysis of randomized controlled trials. Eur J Intern Med. 2021;86:54–65.
Welch SC, Lam SW, Neuner EA, Bauer SR, Bass SN. High-dose versus standard dose oseltamivir for treatment of severe influenza in adult intensive care unit patients. Intensive Care Med. 2015;41(7):1365–6.
Lansbury L, Rodrigo C, Leonardi-Bee J, Nguyen-Van-tam J, Lim WS. Corticosteroids as adjunctive therapy in the treatment of influenza. Cochrane Database Syst Rev. 2019;2019(2):466–7.
World Heart Organization (WHO). Overview - World Health Organization. September 7th. 2022.
Van Kerkhove MD. COVID-19 in 2022: controlling the pandemic is within our grasp. Nat Med. 2021;27(12):2070–0.
Yang H, Rao Z. Structural biology of SARS-CoV-2 and implications for therapeutic development. Nat Rev Microbiol. 2021;19(11):685–700.
Lopes-Pacheco M, Silva PL, Cruz FF, Battaglini D, Robba C, Pelosi P, et al. Pathogenesis of multiple organ injury in COVID-19 and potential therapeutic strategies. Front Physiol. 2021;12:593223.
Robba C, Battaglini D, Pelosi P, Rocco RMP. Multiple organ dysfunction in SARS-CoV-2: MODS-CoV-2. Expert Rev Respir Med. 2020;14(9):865–8.
Huth SF, Cho S-M, Robba C, Highton D, Battaglini D, Bellapart J, et al. Neurological Manifestations of Coronavirus Disease 2019: A comprehensive review and meta-analysis of the first 6 months of pandemic reporting. Front Neurol. 2021:664599.
Premraj L, Kannapadi NV, Briggs J, Seal SM, Battaglini D, Fanning J, et al. Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: a meta-analysis. J Neurol Sci. 2022;434:120162.
Fazzini B, Battaglini D, Carenzo L, Pelosi P, Cecconi M, Puthucheary Z. Physical and psychological impairment in survivors with acute respiratory distress syndrome: a systematic review and meta-analysis. Br J Anaesth. 2022;Online ahead of print
Wang M, Xiong H, Chen H, Li Q, Ruan XZ. Renal injury by SARS-CoV-2 infection: a systematic review. Kidney Dis. 2020;7:1–11.
Orlandi D, Battaglini D, Robba C, Viganò M, Bergamaschi G, Mignatti T, et al. Coronavirus disease 2019 phenotypes, lung ultrasound, chest computed tomography and clinical features in critically ill mechanically ventilated patients. Ultrasound Med Biol. 2021;47(12):3323–32.
Fraile Gutiérrez V, Ayuela Azcárate JM, Pérez-Torres D, Zapata L, Rodríguez Yakushev A, Ochagavía A. Ultrasound in the management of the critically ill patient with SARS-CoV-2 infection (COVID-19): narrative review. Med Intensiva. 2020;44(9):551–65.
Battaglini D, Premraj L, Huth S, Fanning J, Whitman G, Arora RC, et al. The use of noninvasive multimodal neuromonitoring in adult critically ill patients with COVID-19 infection. J Neurosurg Anesthesiol. 2022:10–97.
Battaglini D, Rocco PRM, Pelosi P. New insights in mechanical ventilation and adjunctive therapies in ARDS. Signa Vitae. 2022:1–11.
Battaglini D, Cruz F, Robba C, Pelosi P, Rocco PRM. Failed clinical trials on COVID-19 acute respiratory distress syndrome in hospitalized patients: common oversights and streamlining the development of clinically effective therapeutics. Expert Opin Investig Drugs. 2022;31:995–1015.
Azoulay E, Russell L, Van de Louw A, Metaxa V, Bauer P, Povoa P, et al. Diagnosis of severe respiratory infections in immunocompromised patients. Intensive Care Med. 2020;46(2):298–314.
Luyt CE, Combes A, Deback C, Aubriot-Lorton MH, Nieszkowska A, Trouillet JL, et al. Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation. Am J Respir Crit Care Med. 2007;175(9):935–42.
Ong GM, Lowry K, Mahajan S, Wyatt DE, Simpson C, O’Neill HJ, et al. Herpes simplex type 1 shedding is associated with reduced hospital survival in patients receiving assisted ventilation in a tertiary referral intensive care unit. J Med Virol. 2004;72(1):121–5.
Brenner T, Rosenhagen C, Hornig I, Schmidt K, Lichtenstern C, Mieth M, et al. Viral infections in septic shock (VISS-trial)-crosslinks between inflammation and immunosuppression. J Surg Res. 2012;176(2):571–82.
Schuierer L, Gebhard M, Ruf HG, Jaschinski U, Berghaus TM, Wittmann M, et al. Impact of acyclovir use on survival of patients with ventilator-associated pneumonia and high load herpes simplex virus replication. Crit Care. 2020;24(1)
Hockberger RS, Rothstein RJ. Varicella pneumonia in adults: a spectrum of disease. Ann Emerg Med. 1986;15(8):931–4.
Schildermans J, De Vlieger G. Cytomegalovirus: a troll in the ICU? Overview of the literature and perspectives for the future. Front Med. 2020;7:188.
Heininger A, Haeberle H, Fischer I, Beck R, Riessen R, Rohde F, et al. Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis. Crit Care. 2011;15(2):R77.
Limaye AP, Stapleton RD, Peng L, Gunn SR, Kimball LE, Hyzy R, et al. Effect of ganciclovir on IL-6 levels among cytomegalovirus-seropositive adults with critical illness: a randomized clinical trial. JAMA. 2017;318(8):731–40.
Cowley NJ, Owen A, Shiels SC, Millar J, Woolley R, Ives N, et al. Safety and efficacy of antiviral therapy for prevention of cytomegalovirus reactivation in immunocompetent critically ill patients: a randomized clinical trial. JAMA Intern Med. 2017;177(6):774–83.
Xie Y, Cao S, Dong H, Lv H, Teng X, Zhang J, et al. Clinical characteristics and outcomes of critically ill patients with acute COVID-19 with Epstein-Barr virus reactivation. BMC Infect Dis. 2021;21(1):955.
Libert N, Bigaillon C, Chargari C, Bensalah M, Muller V, Merat S, et al. Epstein-Barr virus reactivation in critically ill immunocompetent patients. Biom J. 2015;38(1):70–6.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Pérez-Torres, D., Battaglini, D., Fuest, K. (2023). Viral Infections in the Intensive Care Unit. In: Pérez-Torres, D., Martínez-Martínez, M., Schaller, S.J. (eds) Best 2022 Clinical Cases in Intensive Care Medicine. Lessons from the ICU. Springer, Cham. https://doi.org/10.1007/978-3-031-36398-6_7
Download citation
DOI: https://doi.org/10.1007/978-3-031-36398-6_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-36397-9
Online ISBN: 978-3-031-36398-6
eBook Packages: MedicineMedicine (R0)