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Molecular Pathology of Lung Tumors

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Molecular Surgical Pathology
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Abstract

Lung carcinomas are among the most common and deadly tumors worldwide. Historically, lung tumors have been treated with a combination of surgery and or chemoradiotherapy with minimal impact on survival in the large numbers of patients who present with advanced-stage disease. However, in the last two decades, a number of breakthroughs in our understanding of the molecular genetics of lung cancer have led to the advent of “targeted therapy” with the response of selected tumors to certain kinase inhibitors and dramatically improved progression-free survival for patients with these cancers. Advancements in the field of immunotherapy, in particular immune checkpoint inhibitors, also significantly improved patient’s outcome and quality of life. This chapter will present the established molecular alterations of lung cancers for which targeted therapies are part of standard clinical practice, as well as emerging genetic alterations that are currently the focus of clinical therapeutic trials. Molecular implication for immunotherapy will also be discussed.

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Acknowledgments

  • The authors thank Dr. Lynette Sholl, Brigham and Women’s Hospital and Harvard Medical School, for her contribution to the preparation of contents in the previous version of this chapter.

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Correspondence to Neal I. Lindeman .

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Lo, YC., Lindeman, N.I. (2023). Molecular Pathology of Lung Tumors. In: Cheng, L., Netto, G.J., Eble, J.N. (eds) Molecular Surgical Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-35118-1_9

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  • DOI: https://doi.org/10.1007/978-3-031-35118-1_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-35117-4

  • Online ISBN: 978-3-031-35118-1

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