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Molecular Pathology of Colorectal Tumors

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Molecular Surgical Pathology

Abstract

Colorectal cancer (CRC) is the second most common cancer in women and the third most common cancer in men worldwide. Incidence of CRC is increasing in many low- and middle-income countries and increasing in young adults under age 50 in Western countries. Recent advances significantly increased the 5-year relative survival of CRC. Our knowledge regarding the molecular pathogenesis of CRC and its predisposing hereditary syndromes has advanced, and new polyposis syndromes are still being discovered. Universal tumor screening algorithms for Lynch syndrome are recommended and widely accepted. It is hopeful that soon, upfront large panel tumor sequencing may be offered as a cost-effective test to cover many indications simultaneously, including assessment of somatic and germline mutations of syndromic genes, universal screening for Lynch syndrome, and evaluation of biomarkers for immune checkpoint inhibitor therapy and other targeted therapy. Leveraging advances in artificial intelligence and statistical methods to create more complex prognostic models that combine pathology, radiology, and molecular predictors is on the horizon.

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Correspondence to Wendy L. Frankel .

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Chen, W., Jones, D., Frankel, W.L. (2023). Molecular Pathology of Colorectal Tumors. In: Cheng, L., Netto, G.J., Eble, J.N. (eds) Molecular Surgical Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-35118-1_5

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  • DOI: https://doi.org/10.1007/978-3-031-35118-1_5

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  • Online ISBN: 978-3-031-35118-1

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