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A Precise Approach for Radiotherapy of Breast Cancer

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Breast Cancer Research and Treatment

Part of the book series: Cancer Treatment and Research ((CTAR,volume 188))

Abstract

Radiotherapy is an integral part of the multidisciplinary management of breast cancer (BC). There have been multiple recent advances in the delivery of radiotherapy, reviewed with a critical discussion of the evidence from trials investigating adjuvant ultra-hypofractionation and partial breast irradiation for early-stage BC, and the locoregional management of lymph nodes in locally advanced BC. Multiple precision medicine-based approaches have been developed as prognostic and/or predictive for BC patients and identifying biomarkers of radioresistance could help identify patients that may benefit from dose-escalated radiotherapy or radiosensitizers. Radiotherapy after breast reconstruction is an area of current controversy in the field, and we evaluated the decision-making considerations in this situation. The oligometastatic state is an emerging field for many cancer sites based on recent trials investigating ablative radiotherapy for oligometastatic BC. This chapter is an overview of radiotherapy for BC, with a focus on recent advances in early-stage, locally advanced, and oligometastatic disease.

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Authors and Affiliations

  1. Department of Oncology - Division of Radiation Oncology, Kingston Health Sciences Centre and Queen’s University, Kingston, Canada

    Samantha Sigurdson, Stephane Thibodeau, Martin Korzeniowski & Fabio Ynoe Moraes

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  1. Samantha Sigurdson
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  2. Stephane Thibodeau
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  3. Martin Korzeniowski
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  4. Fabio Ynoe Moraes
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Correspondence to Fabio Ynoe Moraes .

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Editors and Affiliations

  1. Department of Medical Oncology, Mohammed VI University Hospital, Oujda, Morocco

    Ouissam Al Jarroudi

  2. Department of Medical Oncology, Mohammed VI University Hospital, Oujda, Morocco

    Khalid El Bairi

  3. Division of New Drugs and Early Drug Development, European Institute of Oncology IRCCS, Milan, Italy

    Giuseppe Curigliano

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SS and ST do not declare any conflicts of interest. MK has received honoraria from Knight Pharmaceuticals and Sanofi for outside work on unrelated projects and consulting work. FM has received honoraria from AstraZeneca and IASLC outside the submitted work, declares grants or contracts from CTAQ Queen’s University outside the current work, and has received consulting fees from Cancer em foco outside the submitted work.

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Sigurdson, S., Thibodeau, S., Korzeniowski, M., Moraes, F.Y. (2023). A Precise Approach for Radiotherapy of Breast Cancer. In: Al Jarroudi, O., El Bairi, K., Curigliano, G. (eds) Breast Cancer Research and Treatment. Cancer Treatment and Research, vol 188. Springer, Cham. https://doi.org/10.1007/978-3-031-33602-7_7

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