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Transversal Perspectives of Integrative Oncology Care in Gastric and Lobular Breast Cancer

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Breast Cancer Research and Treatment

Part of the book series: Cancer Treatment and Research ((CTAR,volume 188))

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Abstract

The occurrence of gastric cancer has been associated with an increased risk of lobular breast tumors in a subset of patients harboring selected germline mutations. Among all, the germline alteration of the gene coding for E-Cadherin (CDH1) was associated with an increased risk of gastric cancer diffuse-histotype and lobular breast cancer. However, the risk assessment of breast neoplasms and the role of multiple prophylactic procedures in these patients has never been systematically addressed. In addition, the performance of the common screening procedures for lobular breast cancer like mammography is suboptimal. Therefore, recalling the need for a better articulation of the patient-centered strategies of surveillance for individuals with germline CDH1 and other similar alterations, to offer comprehensive approaches for prevention, early diagnosis, and treatment. Accordingly, this chapter aims to discuss the value and the role of integrated oncological care in the era of oncology sub-specializations. Additionally, it sheds light on how the harmonization across the health providers can enhance patient care in this setting.

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Abbreviations

DGC:

Diffuse gastric cancer

BC:

Breast cancer

PTG:

Prophylactic total gastrectomy

MRI:

Magnetic resonance imaging

US:

Ultrasonography

VUS:

Variants of unknown significance

LBC:

Lobular breast cancer

SRC:

Signet ring cells

HDGC:

Hereditary diffuse gastric cancer

EMT:

Epithelial–mesenchymal transition

HLBC:

Hereditary lobular breast cancer

US:

Ultrasonography

DBT:

Digital breast tomosynthesis

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Authors and Affiliations

  1. Department of Precision Medicine, School of Medicine, University of Study of Campania, 80131, Naples, Italy

    Emilio Francesco Giunta & Gianluca Arrichiello

  2. Hepatology Unit, Ospedale Evangelico Betania, 80147, Naples, Italy

    Annalisa Pappalardo

  3. Medical Oncology Unit, Ospedale del Mare, Via E. Russo, 80147, Naples, Italy

    Piera Federico & Angelica Petrillo

Authors
  1. Emilio Francesco Giunta
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  2. Gianluca Arrichiello
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  3. Annalisa Pappalardo
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  4. Piera Federico
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  5. Angelica Petrillo
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Correspondence to Angelica Petrillo .

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Editors and Affiliations

  1. Department of Medical Oncology, Mohammed VI University Hospital, Oujda, Morocco

    Ouissam Al Jarroudi

  2. Department of Medical Oncology, Mohammed VI University Hospital, Oujda, Morocco

    Khalid El Bairi

  3. Division of New Drugs and Early Drug Development, European Institute of Oncology IRCCS, Milan, Italy

    Giuseppe Curigliano

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EFG received personal fees from Novartis; APe received personal fees from Eli-Lilly, Merck, MSD, BMS, Amgen, Roche and Servier. No fees are connected with this chapter. The other authors declare no conflicts of interest.

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Giunta, E.F., Arrichiello, G., Pappalardo, A., Federico, P., Petrillo, A. (2023). Transversal Perspectives of Integrative Oncology Care in Gastric and Lobular Breast Cancer. In: Al Jarroudi, O., El Bairi, K., Curigliano, G. (eds) Breast Cancer Research and Treatment. Cancer Treatment and Research, vol 188. Springer, Cham. https://doi.org/10.1007/978-3-031-33602-7_4

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