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Mechano-Electric Coupling in the Heart: Effects on Heart Rate and Rhythm

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Heart Rate and Rhythm

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Abstract

Cardiac electrical and mechanical activity are closely interrelated, not only via the chain of events commonly referred to as ‘excitation-contraction coupling’ that links electrical excitation to contraction, but equally via feedback from the heart’s mechanical environment to the origin and spread of cardiac excitation. The latter has been termed mechano-electric coupling and complements excitation-contraction coupling to form an intracardiac electro-mechanical regulatory loop. This chapter will explore the relevance of mechano-electric coupling in the heart by reviewing its pro- and anti-arrhythmic effects on heart rate and rhythm, and the underlying mechanisms that may account for clinical and experimental observations.

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Acknowledgements

Work in the authors’ laboratories is supported by the Canadian Institutes of Health Research (MOP 342562 to TAQ), the Natural Sciences and Engineering Research Council of Canada (RGPIN-2016-04879 to TAQ), the Heart and Stroke Foundation of Canada (G-18-0022185 and National New Investigator Award to TAQ), and the German Research Foundation (Collaborative Research Centre ‘SFB 1425’ #422681845; PK). RAC was supported by the Wellcome Trust and Royal Society (109371/Z/15/Z).

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Dalhousie University, Halifax, NS, Canada

    T. Alexander Quinn

  2. School Biomedical Engineering, Dalhousie University, Halifax, NS, Canada

    T. Alexander Quinn

  3. Department of Pharmacology, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK

    Rebecca A. Capel

  4. Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg Bad Krozingen, Freiburg, Germany

    Peter Kohl

  5. Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Peter Kohl

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  1. T. Alexander Quinn
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  2. Rebecca A. Capel
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  3. Peter Kohl
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Correspondence to T. Alexander Quinn .

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Editors and Affiliations

  1. Cardiac Electrophysiology Division, Ion Channel Study Center, Life Science Academy, Lucknow, India

    Onkar N. Tripathi

  2. Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada

    T. Alexander Quinn

  3. Institute for Experimental Cardiovascular Medicine, University Heart Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Ursula Ravens

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Quinn, T.A., Capel, R.A., Kohl, P. (2023). Mechano-Electric Coupling in the Heart: Effects on Heart Rate and Rhythm. In: Tripathi, O.N., Quinn, T.A., Ravens, U. (eds) Heart Rate and Rhythm. Springer, Cham. https://doi.org/10.1007/978-3-031-33588-4_7

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  • DOI: https://doi.org/10.1007/978-3-031-33588-4_7

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