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Calmodulin Kinase II Regulation of Heart Rhythm and Disease

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Abstract

Calmodulin kinase II (CaMKII) is expressed in tissues throughout the body with essential roles in a wide variety of cellular functions from synaptic transmission in neurons to solute absorption in the epithelium to excitation–contraction coupling in cardiac myocytes. Importantly, CaMKII activity is sensitive to a variety of physiologically relevant stimuli, including intracellular Ca2+ and reactive oxygen species. In cardiomyocytes, CaMKII targets a host of intracellular substrates, including ion channels, Ca2+ cycling proteins, and transcription factors to regulate cardiac contractility, pacemaking, and electrical conduction. This chapter discusses the multiple roles of CaMKII in the heart and its emergence as an important determinant of the heart’s response to both acute and chronic stress relevant to normal physiology as well as disease.

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Acknowledgments

This work was supported by the National Institutes of Health (HL096805, HL135096, and HL134824 to TJH).

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Authors and Affiliations

  1. The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    Drew M. Nassal & Thomas J. Hund

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  1. Drew M. Nassal
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  2. Thomas J. Hund
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Correspondence to Thomas J. Hund .

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Editors and Affiliations

  1. Cardiac Electrophysiology Division, Ion Channel Study Center, Life Science Academy, Lucknow, India

    Onkar N. Tripathi

  2. Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada

    T. Alexander Quinn

  3. Institute for Experimental Cardiovascular Medicine, University Heart Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Ursula Ravens

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Nassal, D.M., Hund, T.J. (2023). Calmodulin Kinase II Regulation of Heart Rhythm and Disease. In: Tripathi, O.N., Quinn, T.A., Ravens, U. (eds) Heart Rate and Rhythm. Springer, Cham. https://doi.org/10.1007/978-3-031-33588-4_22

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