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The Infant–Mother Molecular Conversation Involving Breast Milk mRNA

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Breastfeeding and Metabolic Programming

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Abstract

In mammalian species, there is an ongoing biological dialogue between the mother and offspring from the moment the blastocyst first implants up to the end of breastfeeding. In utero, signals pass via the placenta, whilst postpartum signalling occurs via milk to the gut. MicroRNAs (miRNAs) are brief unpaired sequences of RNA, around 22 nucleotides in total, which feature in many aspects of normal physiology and development. This chapter looks at the part played by miRNAs in the complex molecular dialogue shaping the development of the child, from the moment of implantation up to birth and beyond. The fact that miRNAs can be identified in so many body fluids, including amniotic fluid, the blood of the cord and in human milk means that a new way to understand normal and abnormal physiological processes in development has appeared, and raises the hope that one day new, non-invasive biomarkers will be found [1].

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Authors and Affiliations

  1. Department of Child Health and Diseases, Arel University, Medical Faculty, Istanbul, Türkiye

    Özlem Naciye Şahin

  2. NICU, Third Department of Pediatrics, National and Kapodistrian University of Athens, University General Hospital “ATTIKON”, Athens, Greece

    Despina D. Briana

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  1. Özlem Naciye Şahin
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Editors and Affiliations

  1. Department of Child Health and Diseases, Arel University, Medical Faculty, Istanbul, Türkiye

    Özlem Naciye Şahin

  2. Pediatrics Department, National and Kapodistrian University of Athens, Athens, Greece

    Despina D. Briana

  3. Department of Obstetrics and Gynecology, University of Perugia, Perugia, Perugia, Italy

    Gian Carlo Di Renzo

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Şahin, Ö.N., Briana, D.D. (2023). The Infant–Mother Molecular Conversation Involving Breast Milk mRNA. In: Şahin, Ö.N., Briana, D.D., Di Renzo, G.C. (eds) Breastfeeding and Metabolic Programming. Springer, Cham. https://doi.org/10.1007/978-3-031-33278-4_14

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