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Late Effects of Penile Cancer

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Penile Cancer – A Practical Guide

Part of the book series: Management of Urology ((MU))

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Abstract

Penile cancer therapy should encompass treatment of the primary cancer and lymph nodes, whilst optimising cosmetic appearance and function. Late effects of treatment include urinary changes, sexual dysfunction, genital and lower limb lymphoedema. Urinary symptoms can occur due to recurrence of pathologies that predisposed patients to developing penile cancer in the first place such as lichen sclerosis, external factors from genital lymphoedema causing penile burying, or secondary to scarring due to the surgery itself including meatal stenosis. Sexual function encompasses both physical and psychological components and is dependent on the procedure performed, with more radical approaches leading to lower patient satisfaction rates. Patients can also experience body and self-image challenges because of treatment that need to be considered in their holistic management. Lymphoedema occurs due to the disruption of lymphatics when nodal sampling or nodal dissection occurs. The accumulation of lymph fluid contributes to loss of elasticity and hyperplasia of connective tissue and ultimately fibrosis. This result clinically, in hyperkeratosis, dermal thickening, hyperpigmentation, increased skin folds, warty overgrowths and occasionally malignant transformation.

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References

  1. Tashiro K, Yamashita S, Saito T, Iida T, Koshima I. Proximal and distal patterns: different spreading patterns of indocyanine green lymphography in secondary lower extremity lymphedema. J Plast Reconstr Aesthet Surg. 2016;69(3):368–75.

    Article  PubMed  Google Scholar 

  2. Zaleska M, Olszewski WL, Durlik M. The effectiveness of intermittent pneumatic compression in long-term therapy of lymphedema of lower limbs. Lymphat Res Biol. 2014;12:103–9.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Monteiro LL, Skowronski R, Brimo F, et al. Erectile function after partial penectomy for penile cancer. Int Braz J Urol. 2021;47(3):515–22.

    Article  PubMed  Google Scholar 

  4. Sedigh O, Falcone M, Ceruti C, et al. Sexual function after surgical treatment for penile cancer: which organ-sparing approach gives the best results? Can Urol Assoc J. 2015;9(7–8):E423–7.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Preto M, Falcone M, Blecher G, et al. Functional and patient reported outcomes following Total glans resurfacing. J Sex Med. 2021;18(6):1099–103.

    Article  PubMed  Google Scholar 

  6. Sansalone S, Silvani M, Leonardi R, et al. Sexual outcomes after partial penectomy for penile cancer: results from a multi-institutional study. Asian J Androl. 2017;19(1):57–61.

    Article  PubMed  Google Scholar 

  7. Romero FR, Romero KR, Mattos MA, Garcia CR, Fernandes Rde C, Perez MD. Sexual function after partial penectomy for penile cancer. Urology. 2005;66(6):1292–5.

    Article  PubMed  Google Scholar 

  8. Warren AG, Brorson H, Borud LJ, et al. Lymphedema: a comprehensive review. Ann Plast Surg. 2007;59:464–72.

    Article  CAS  PubMed  Google Scholar 

  9. Clodius L. Lymphatics, lymphodynamics, lymphedema: an update. Plast Surg Outlook. 1990;4:1.

    Google Scholar 

  10. Morey AF, Meng MV, McAninch JW. Skin graft reconstruction of chronic genital lymphedema. Urology. 1997;50:423–6.

    Article  CAS  PubMed  Google Scholar 

  11. Namir SA, Trattner A. Transient idiopathic primary penoscrotal edema. Indian J Dermatol. 2013;58(5):408.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Smeltzer DM, Stickler GB, Schirger A. Primary lymphedema in children and adolescents: a follow-up study and review. Pediatrics. 1985;76:206.

    CAS  PubMed  Google Scholar 

  13. Aulia I, Yessica EC. Surgical management of male genital lymphedema: a systematic review. Arch Plast Surg. 2020;47(1):3–8.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Halperin TJ, Salvin SA, Olumi AF, et al. Surgical management of scrotal lymphedema using local flaps. Ann Plast Surg. 2007;59:67–72. discussion 72

    Article  CAS  PubMed  Google Scholar 

  15. Modolin M, Mitre AI, da Silva JC, et al. Surgical treatment of lymphedema of the penis and scrotum. Clinics (Sao Paulo). 2006;61:289–94.

    Article  PubMed  Google Scholar 

  16. Bevan-Thomas R, Slaton JW, Pettaway CA. Contemporary morbidity from lymphadenectomy for penile squamous carcinoma: the MD Anderson Cancer Center Experience. J Urol. 2002;167:1638–42.

    Article  PubMed  Google Scholar 

  17. Protzel C, Alcaraz A, Horenblas S, et al. Lymphadenectomy in the surgical management of penile cancer. Eur Urol. 2009;55:1075–88.

    Article  PubMed  Google Scholar 

  18. Alnajjar HM, Castiglione F, Ahmed K, Haider A, Nigam R, Muneer A. A novel 'Batman' scrotectomy technique for the management of scrotal lymphoedema following treatment for penile cancer. Transl Androl Urol. 2019;8(5):448–56.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Prostate Cancer UK. Research into wellbeing services for men with prostate cancer –final report 2014 [Available from: https://prostatecanceruk.org/media/2460122/Report-Wellbeing-services-for-men-with-prostate-cancer.pdf.

  20. Brunckhorst O, Stewart R, Ahmed K. Ch 20 mind and body in men’s health. In: Goonewardene S, Brunckhorst O, Albala D, Ahmed K, editors. Trends in men’s health. 1st ed. Springer; 2022.

    Google Scholar 

  21. Koch L, Jansen L, Brenner H, Arndt V. Fear of recurrence and disease progression in long-term (>/= 5 years) cancer survivors—a systematic review of quantitative studies. Psychooncology. 2013;22(1):1–11.

    Article  CAS  PubMed  Google Scholar 

  22. Cicognani E. Social Well-being. In: Michalos AC, editor. Encyclopedia of quality of life and Well-being research. Dordrecht: Springer Netherlands; 2014. p. 6193–7.

    Chapter  Google Scholar 

  23. Umberson D, Montez JK. Social relationships and health: a flashpoint for health policy. J Health Soc Behav. 2010;51(Suppl):S54–66.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Maddineni SB, Lau MM, Sangar VK. Identifying the needs of penile cancer sufferers: a systematic review of the quality of life, psychosexual and psychosocial literature in penile cancer. BMC Urol. 2009;9:8.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Paster IC, Chipollini J. Importance of addressing the psychosocial impact of penile cancer on patients and their families. Semin Oncol Nurs. 2022;151286

    Google Scholar 

  26. Ficarra V, Righetti R, D'Amico A, Pilloni S, Balzarro M, Schiavone D, et al. General state of health and psychological well-being in patients after surgery for urological malignant neoplasms. Urol Int. 2000;65(3):130–4.

    Article  CAS  PubMed  Google Scholar 

  27. Drager DL, Protzel C, Hakenberg OW. Identifying psychosocial distress and stressors using distress-screening instruments in patients with localized and advanced penile cancer. Clin Genitourin Cancer. 2017;15(5):605–9.

    Article  PubMed  Google Scholar 

  28. Harju E, Pakarainen T, Vasarainen H, Tornava M, Helminen M, Perttila I, et al. Health-related quality of life, self-esteem and sexual functioning among patients operated for penile cancer—a cross-sectional study. J Sex Med. 2021;18(9):1524–31.

    Article  PubMed  Google Scholar 

  29. Tornava M, Harju E, Vasarainen H, Pakarainen T, Perttila I, Kaipia A. Men's experiences of the impact of penile cancer surgery on their lives: a qualitative study. Eur J Cancer Care (Engl). 2022;31(1):e13548.

    Article  PubMed  Google Scholar 

  30. Sosnowski R, Wolski JK, Zi Talewicz U, Szyma Ski M, Baku AR, Demkow T. Assessment of selected quality of life domains in patients who have undergone conservative or radical surgical treatment for penile cancer: an observational study. Sex Health. 2019;16(1):32–8.

    Article  PubMed  Google Scholar 

  31. Witty K, Branney P, Evans J, Bullen K, White A, Eardley I. The impact of surgical treatment for penile cancer—patients' perspectives. Eur J Oncol Nurs. 2013;17(5):661–7.

    Article  PubMed  Google Scholar 

  32. Bullen K, Edwards S, Marke V, Matthews S. Looking past the obvious: experiences of altered masculinity in penile cancer. Psychooncology. 2010;19(9):933–40.

    Article  PubMed  Google Scholar 

  33. Yu C, Hequn C, Longfei L, Minfeng C, Zhi C, Feng Z, et al. Sexual function after partial penectomy: a prospectively study from China. Sci Rep. 2016;6:21862.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Dinesh AA, Helena Pagani Soares Pinto S, Brunckhorst O, Dasgupta P, Ahmed K. Anxiety, depression and urological cancer outcomes: a systematic review. Urol Oncol. 2021;39(12):816–28.

    Article  PubMed  Google Scholar 

  35. Kiffel J, Sher L. Prevention and management of depression and suicidal behavior in men with prostate cancer. Front Public Health. 2015;3:28.

    Article  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Urology, University College London Hospital, London, UK

    Clare Akers & Stanley Tang

  2. MRC Centre for Transplantation, Guy’s Hospital Campus, King’s College London, King’s Health Partners, London, UK

    Oliver Brunckhorst

  3. Department of Urology, NHS Greater Glasgow & Clyde, Glasgow, UK

    Matthew Rewhorn

Authors
  1. Clare Akers
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  2. Stanley Tang
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  3. Oliver Brunckhorst
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  4. Matthew Rewhorn
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Corresponding author

Correspondence to Matthew Rewhorn .

Editor information

Editors and Affiliations

  1. King’s College London, London, UK

    Oliver Brunckhorst

  2. King’s College London, London, UK

    Kamran Ahmed

  3. University College London Hospital and University College London, London, UK

    Asif Muneer

  4. University College London Hospital and University College London, London, UK

    Hussain M Alnajjar

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Akers, C., Tang, S., Brunckhorst, O., Rewhorn, M. (2023). Late Effects of Penile Cancer. In: Brunckhorst, O., Ahmed, K., Muneer, A., Alnajjar, H.M. (eds) Penile Cancer – A Practical Guide. Management of Urology. Springer, Cham. https://doi.org/10.1007/978-3-031-32681-3_11

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  • DOI: https://doi.org/10.1007/978-3-031-32681-3_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-32680-6

  • Online ISBN: 978-3-031-32681-3

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