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Impact of Prenatal Nicotine Exposure on Placental Function and Respiratory Neural Network Development

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Advances in Maternal-Fetal Biomedicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1428))

Abstract

Smoking during pregnancy is associated with multiple undesirable outcomes in infants, such as low birth weight, increased neonatal morbidity and mortality, and catastrophic conditions like sudden infant death syndrome (SIDS). Nicotine, the most addictive and teratogenic substance in tobacco smoke, reaches and crosses the placenta and can be accumulated in the amniotic fluid and distributed by fetal circulation, altering the cholinergic transmission by acting on the nicotinic acetylcholine receptors (nAChRs) expressed from very early gestational stages in the placenta and fetal tissue. Because nAChRs influence the establishment of feto-maternal circulation and the emergence of neuronal networks, prenatal nicotine exposure can lead to multiple alterations in newborns. In this mini-review, we discuss the undeniable effects of nicotine in the placenta and the respiratory neural network as examples of how prenatal nicotine and smoking exposition can affect brain development because dysfunction in this network is involved in SIDS etiology.

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Change history

  • 26 September 2023

    A correction has been published.

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Acknowledgments

FONDECYT de iniciación 11230857 to SBC and FONDECYT 1211359 to JE.

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Authors and Affiliations

  1. Centro integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O’Higgins, Santiago, Chile

    Sebastián Beltrán-Castillo

  2. Laboratorio de Sistemas Neurales, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile USACH, Santiago, Chile

    Karina Bravo & Jaime Eugenín

  3. Facultad de Ingeniería, Universidad Autónoma de Chile, Santiago, Chile

    Karina Bravo

Authors
  1. Sebastián Beltrán-Castillo
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  2. Karina Bravo
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  3. Jaime Eugenín
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Corresponding authors

Correspondence to Sebastián Beltrán-Castillo or Jaime Eugenín .

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Editors and Affiliations

  1. Laboratorio de Investigación Materno-Fetal (LIMaF) Departamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Concepción, Concepción, Chile

    Marcelo Gonzalez-Ortiz

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Beltrán-Castillo, S., Bravo, K., Eugenín, J. (2023). Impact of Prenatal Nicotine Exposure on Placental Function and Respiratory Neural Network Development. In: Gonzalez-Ortiz, M. (eds) Advances in Maternal-Fetal Biomedicine. Advances in Experimental Medicine and Biology, vol 1428. Springer, Cham. https://doi.org/10.1007/978-3-031-32554-0_10

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