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Noninvasive Ventilatory Approaches in Neonatology

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Upper Airway Disorders and Noninvasive Mechanical Ventilation
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Abstract

Neonatal upper airway anatomy and respiratory physiology puts newborns in a higher risk for upper airflow obstruction and respiratory failure. Newborns may present with a wide spectrum of upper airway disorders that may be congenital or acquired. Nasal obstruction such as choanal atresia; oropharyngeal obstruction due to macroglossia, micrognathia, and/or glossoptosis; or laryngeal obstruction such as laryngomalacia are the main disorders that can cause respiratory failure in the newborns. Noninvasive ventilatory approach should be viewed as a potential weapon in the management of these patients, since it can provide respiratory support during the first weeks to months of life as an alternative to more invasive approach or as a bridge to surgical interventions. In many cases, noninvasive ventilation (NIV) allows for a shorter length of hospital stay, less complications, and better quality of care for newborns.

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References

  1. Bergeson PS, Shaw JC. Are infants really obligatory nasal breathers? Clin Pediatr (Phila). 2001;40(10):567–9.

    Article  CAS  PubMed  Google Scholar 

  2. Carpenter RJ, Neel HB. Correction of congenital choanal atresia in children and adults. Laryngoscope. 1977;87(8):1304–11.

    Article  CAS  PubMed  Google Scholar 

  3. Paradis J, Dzioba A, El-Hakim H, Hong P, Kozak FK, Nguyen LHP, et al. A national study of choanal atresia in tertiary care centers in Canada–part I: clinical presentation. J Otolaryngol Head Neck Surg. 2021;50(1):45.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Paradis J, Dzioba A, El-Hakim H, Hong P, Kozak FK, Nguyen LHP, et al. A national study of choanal atresia in tertiary care centers in Canada–part II: clinical management. J Otolaryngol Head Neck Surg. 2021;50(1):46.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Frank S, Schoem SR. Nasal obstruction in the infant. Pediatr Clin N Am. 2022;69(2):287–300.

    Article  Google Scholar 

  6. Stromiedel H, Van Quekelberghe C, Yigit G, Al Naimi A, Bahlmann F, Sader R, et al. A newborn suffering from arhinia: neonatologic challenges during primary care of the newborn with Bosma Arhinia Microphthalmia Syndrome (BAMS). Laryngorhinootologie. 2021;100(4):294–6.

    PubMed  Google Scholar 

  7. Kumar S, Jain M, Sogi S, Thukral A. McGovern nipple: an alternative for nose breathing in newborn with CHARGE syndrome, having bilateral choanal atresia. J Indian Soc Pedod Prev Dent. 2020;38:204–7.

    Article  PubMed  Google Scholar 

  8. Evans KN, Sie KC, Hopper RA, Glass RP, Hing AV, Cunningham ML. Robin sequence: from diagnosis to development of an effective management plan. Pediatrics. 2011;127(5):936–48.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Robin P. A fall of the base of the tongue considered as a new cause of nasopharyngeal respiratory impairment: Pierre Robin sequence, a translation. 1923. Plast Reconstr Surg. 1994;93(6):1301–3.

    Article  CAS  PubMed  Google Scholar 

  10. van den Elzen AP, Semmekrot BA, Bongers EM, Huygen PL, Marres HA. Diagnosis and treatment of the Pierre Robin sequence: results of a retrospective clinical study and review of the literature. Eur J Pediatr. 2001;160(1):47–53.

    Article  PubMed  Google Scholar 

  11. Marcus CL, Carroll JL, Koerner CB, Hamer A, Lutz J, Loughlin GM. Determinants of growth in children with the obstructive sleep apnea syndrome. J Pediatr. 1994;125(4):556–62.

    Article  CAS  PubMed  Google Scholar 

  12. Cielo CM, Duffy KA, Taylor JA, Marcus CL, Kalish JM. Obstructive sleep apnea in children with Beckwith-Wiedemann syndrome. J Clin Sleep Med. 2019;15(03):375–81.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Cielo CM, Montalva FM, Taylor JA. Craniofacial disorders associated with airway obstruction in the neonate. Semin Fetal Neonatal Med. 2016;21(4):254–62.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Follmar A, Dentino K, Abramowicz S, Padwa BL. Prevalence of sleep-disordered breathing in patients with Beckwith-Wiedemann syndrome. J Craniofac Surg. 2014;25(5):1814–7.

    Article  PubMed  Google Scholar 

  15. Akre H, Øverland B, Åsten P, Skogedal N, Heimdal K. Obstructive sleep apnea in Treacher Collins syndrome. Eur Arch Otorhinolaryngol. 2012;269(1):331–7.

    Article  PubMed  Google Scholar 

  16. Schwab RJ, Pasirstein M, Pierson R, Mackley A, Hachadoorian R, Arens R, et al. Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging. Am J Respir Crit Care Med. 2003;168(5):522–30.

    Article  PubMed  Google Scholar 

  17. Herrmann ME, Mileusnic D, Jorden M, Kalelkar MB. Sudden death in an 8-week-old infant with Beckwith-Wiedemann syndrome. Am J Forensic Med Pathol. 2000;21(3):276–80.

    Article  CAS  PubMed  Google Scholar 

  18. Caouette-Laberge L, Bayet B, Larocque Y. The Pierre Robin sequence: review of 125 cases and evolution of treatment modalities. Plast Reconstr Surg. 1994;93(5):934–42.

    Article  CAS  PubMed  Google Scholar 

  19. Evans AK, Rahbar R, Rogers GF, Mulliken JB, Volk MS. Robin sequence: a retrospective review of 115 patients. Int J Pediatr Otorhinolaryngol. 2006;70(6):973–80.

    Article  PubMed  Google Scholar 

  20. Schaefer RB, Stadler JA, Gosain AK. To distract or not to distract: an algorithm for airway Management in Isolated Pierre Robin Sequence. Plast Reconstr Surg. 2004;113(4):1113–25.

    Article  PubMed  Google Scholar 

  21. Smith MC, Senders CW. Prognosis of airway obstruction and feeding difficulty in the Robin sequence. Int J Pediatr Otorhinolaryngol. 2006;70(2):319–24.

    Article  PubMed  Google Scholar 

  22. Poets CF, Bacher M. Treatment of upper airway obstruction and feeding problems in Robin-like phenotype. J Pediatr. 2011;159(6):887–92.

    Article  PubMed  Google Scholar 

  23. Anderson KD, Cole A, Chuo CB, Slator R. Home management of upper airway obstruction in Pierre Robin sequence using a nasopharyngeal airway. Cleft Palate Craniofac J. 2007;44(3):269–73.

    Article  CAS  PubMed  Google Scholar 

  24. Olson TS, Kearns DB, Pransky SM, Seid AB. Early home management of patients with Pierre Robin sequence. Int J Pediatr Otorhinolaryngol. 1990;20(1):45–9.

    Article  CAS  PubMed  Google Scholar 

  25. Wagener S, Rayatt SS, Tatman AJ, Gornall P, Slator R. Management of infants with Pierre Robin sequence. Cleft Palate Craniofac J. 2003;40(2):180–5.

    Article  PubMed  Google Scholar 

  26. Parhizkar N, Saltzman B, Grote K, Starr J, Cunningham M, Perkins J, et al. Nasopharyngeal airway for management of airway obstruction in infants with micrognathia. Cleft Palate Craniofac J. 2011;48(4):478–82.

    Article  PubMed  Google Scholar 

  27. Chang AB, Masters IB, Williams GR, Harris M, O’Neil MC. A modified nasopharyngeal tube to relieve high upper airway obstruction. Pediatr Pulmonol. 2000;29(4):299–306.

    Article  CAS  PubMed  Google Scholar 

  28. Randhawa PS, Ahmed J, Nouraei SR, Wyatt ME. Impact of long-term nasopharyngeal airway on health-related quality of life of children with obstructive sleep apnea caused by syndromic Craniosynostosis. J Craniofac Surg. 2011;22(1):125–8.

    Article  PubMed  Google Scholar 

  29. Saboye J, Tournier JJ, Gerardin P, Elicegui M. Traitement néonatal par tube nasopharyngé dans les séquences de Pierre-Robin stade 3. Rev Stomatol Chir Maxillofac Chir Orale. 2015;116(4):235–8.

    CAS  PubMed  Google Scholar 

  30. Pielou WD. Non-surgical management of Pierre Robin syndrome. Arch Dis Child. 1967;42(221):20–3.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  31. von Bodman A, Buchenau W, Bacher M, Arand J, Urschitz MS, Poets CF. Die Tübinger Gaumenplatte—Ein innovatives Therapiekonzept bei Pierre-Robin-Sequenz. Wien Klin Wochenschr. 2003;115(24):871–3.

    Article  Google Scholar 

  32. Bacher M, Sautermeister J, Urschitz MS, Buchenau W, Arand J, Poets CF. An oral appliance with velar extension for treatment of obstructive sleep apnea in infants with Pierre Robin sequence. Cleft Palate Craniofac J. 2011;48(3):331–6.

    Article  PubMed  Google Scholar 

  33. Buchenau W, Urschitz MS, Sautermeister J, Bacher M, Herberts T, Arand J, et al. A randomized clinical trial of a new orthodontic appliance to improve upper airway obstruction in infants with Pierre Robin sequence. J Pediatr. 2007;151(2):145–9.

    Article  PubMed  Google Scholar 

  34. Bedi PK, Castro-Codesal ML, Featherstone R, AlBalawi MM, Alkhaledi B, Kozyrskyj AL, et al. Long-term non-invasive ventilation in infants: a systematic review and meta-analysis. Front Pediatr. 2018;6:13.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Leboulanger N, Picard A, Soupre V, Aubertin G, Denoyelle F, Galliani E, et al. Physiologic and clinical benefits of noninvasive ventilation in infants with Pierre Robin sequence. Pediatrics. 2010;126(5):e1056–63.

    Article  PubMed  Google Scholar 

  36. Amaddeo A, Abadie V, Chalouhi C, Kadlub N, Frapin A, Lapillonne A, et al. Continuous positive airway pressure for upper airway obstruction in infants with Pierre Robin sequence. Plast Reconstr Surg. 2016;137(2):609–12.

    Article  CAS  PubMed  Google Scholar 

  37. Kam K, McKay M, Mac Lean J, Witmans M, Spier S, Mitchell I. Surgical versus nonsurgical interventions to relieve upper airway obstruction in children with Pierre Robin sequence. Can Respir J. 2015;22(3):171–5.

    Article  PubMed Central  PubMed  Google Scholar 

  38. Amaddeo A, Khirani S, Frapin A, Teng T, Griffon L, Fauroux B. High-flow nasal cannula for children not compliant with continuous positive airway pressure. Sleep Med. 2019;63:24–8.

    Article  PubMed  Google Scholar 

  39. Marques IL, Monteiro LCS, de Souza L, Bettiol H, Sassaki CH, de Assumpção CR. Gastroesophageal reflux in severe cases of Robin sequence treated with nasopharyngeal intubation. Cleft Palate Craniofacial J. 2009;46(4):448–53.

    Article  Google Scholar 

  40. Baujat G, Faure C, Zaouche A, Viarme F, Couly G, Abadie V. Oroesophageal motor disorders in Pierre Robin syndrome. J Pediatr Gastroenterol Nutr. 2001;32(3):297–302.

    Article  CAS  PubMed  Google Scholar 

  41. Zalzal HG, Zalzal GH. Stridor in the infant patient. Pediatr Clin N Am. 2022;69(2):301–17.

    Article  Google Scholar 

  42. Olney DR, Greinwald JH, Smith RJ, Bauman NM. Laryngomalacia and its treatment. Laryngoscope. 1999;109(11):1770–5.

    Article  CAS  PubMed  Google Scholar 

  43. Ryan MA, Upchurch PA, Senekki-Florent P. Neonatal vocal fold paralysis. NeoReviews. 2020;21(5):e308–22.

    Article  PubMed  Google Scholar 

  44. Jabbour J, Martin T, Beste D, Robey T. Pediatric vocal fold immobility. JAMA Otolaryngol Neck Surg. 2014;140(5):428.

    Article  Google Scholar 

  45. Kovesi T, Porcaro F, Petreschi F, Trozzi M, Bottero S, Cutrera R. Vocal cord paralysis appears to be an acquired lesion in children with repaired esophageal atresia/tracheoesophageal fistula. Int J Pediatr Otorhinolaryngol. 2018;112:45–7.

    Article  PubMed  Google Scholar 

  46. Zur KB, Douglas J, Carroll LM. Intubation-related laryngeal deficiency and vocal fold immobility in pediatric premature patients. Laryngoscope. 2021;131(11):2550–7.

    Article  PubMed  Google Scholar 

  47. Hartnick CJ, Cotton RT. Congenital laryngeal anomalies. Otolaryngol Clin N Am. 2000;33(6):1293–308.

    Article  CAS  Google Scholar 

  48. Simons JP, Greenberg LL, Mehta DK, Fabio A, Maguire RC, Mandell DL. Laryngomalacia and swallowing function in children. Laryngoscope. 2016;126(2):478–84.

    Article  PubMed  Google Scholar 

  49. Cooper T, Benoit M, Erickson B, El-Hakim H. Primary presentations of Laryngomalacia. JAMA Otolaryngol Head Neck Surg. 2014;140(6):521–6.

    Article  PubMed  Google Scholar 

  50. Carter J, Rahbar R, Brigger M, Chan K, Cheng A, Daniel SJ, et al. International pediatric ORL group (IPOG) laryngomalacia consensus recommendations. Int J Pediatr Otorhinolaryngol. 2016;86:256–61.

    Article  PubMed  Google Scholar 

  51. Zoumalan R, Maddalozzo J, Holinger LD. Etiology of stridor in infants. Ann Otol Rhinol Laryngol. 2007;116(5):329–34.

    Article  PubMed  Google Scholar 

  52. Daya H, Hosni A, Bejar-Solar I, Evans JNG, Bailey CM. Pediatric vocal fold paralysis. Arch Otolaryngol Neck Surg. 2000;126(1):21.

    Article  CAS  Google Scholar 

  53. Rosin DF, Handler SD, Potsic WP, Wetmore RF, Tom LWC. Vocal cord paralysis in children. Laryngoscope. 1990;100(11):1174–9.

    Article  CAS  PubMed  Google Scholar 

  54. Amin MR, Isaacson G. State-dependent laryngomalacia. Ann Otol Rhinol Laryngol. 1997;106(11):887–90.

    Article  CAS  PubMed  Google Scholar 

  55. Isaac A, Zhang H, Soon SR, Campbell S, El-Hakim H. A systematic review of the evidence on spontaneous resolution of laryngomalacia and its symptoms. Int J Pediatr Otorhinolaryngol. 2016;83:78–83.

    Article  PubMed  Google Scholar 

  56. Leonard JA, Reilly BK. Laryngomalacia in the premature neonate. NeoReviews. 2021;22(10):e653–9.

    Article  PubMed  Google Scholar 

  57. Richter GT, Thompson DM. The surgical Management of Laryngomalacia. Otolaryngol Clin N Am. 2008;41(5):837–64.

    Article  Google Scholar 

  58. Fauroux B, Pigeot J, Polkey MI, Roger G, Boulé M, Clément A, et al. Chronic stridor caused by Laryngomalacia in children. Am J Respir Crit Care Med. 2001;164(10):1874–8.

    Article  CAS  PubMed  Google Scholar 

  59. Essouri S, Nicot F, Clément A, Garabedian E-N, Roger G, Lofaso F, et al. Noninvasive positive pressure ventilation in infants with upper airway obstruction: comparison of continuous and bilevel positive pressure. Intensive Care Med. 2005;31(4):574–80.

    Article  PubMed  Google Scholar 

  60. Farhood Z, Ong AA, Nguyen SA, Gillespie MB, Discolo CM, White DR. Objective outcomes of Supraglottoplasty for children with Laryngomalacia and obstructive sleep apnea: a meta-analysis. JAMA Otolaryngol Head Neck Surg. 2016;142(7):665–71.

    Article  PubMed  Google Scholar 

  61. Veroul E, Amaddeo A, Leboulanger N, Gelin M, Denoyelle F, Thierry B, et al. Noninvasive respiratory support as an alternative to tracheostomy in severe Laryngomalacia. Laryngoscope. 2021;132:1861. https://doi.org/10.1002/lary.29928.

    Article  PubMed  Google Scholar 

  62. Ayari S, Aubertin G, Girschig H, Van Den Abbeele T, Denoyelle F, Couloignier V, et al. Management of laryngomalacia. Eur Ann Otorhinolaryngol Head Neck Dis. 2013;130(1):15–21.

    Article  CAS  PubMed  Google Scholar 

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Freitas, A. (2023). Noninvasive Ventilatory Approaches in Neonatology. In: Esquinas, A.M., De Vito, A., Barbetakis, N. (eds) Upper Airway Disorders and Noninvasive Mechanical Ventilation. Springer, Cham. https://doi.org/10.1007/978-3-031-32487-1_32

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  • DOI: https://doi.org/10.1007/978-3-031-32487-1_32

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