Abstract
The physiology and management of hypoventilation in neuromuscular diseases are the hallmarks of this area of research, as the consequent respiratory failure constitutes the major cause of morbidity and mortality of these patients. However, the impact of the upper airway disorders in the pathophysiology and noninvasive ventilation (NIV) effectiveness is less established. In this chapter, we will review the disturbances of the upper airway in neuromuscular disorders and explore their interaction with mechanical insufflation-exsufflation (MIE) and noninvasive ventilation device functioning and efficiency.
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References
Andersen TM, Hov B, Halvorsen T, Røksund OD, Vollsæter M. Upper airway assessment and responses during mechanically assisted cough. Respir Care. 2021;66:1196–213.
Ruoppolo G, Onesti E, Gori MC, et al. Laryngeal sensitivity in patients with amyotrophic lateral sclerosis. Front Neurol. 2016;7:212. https://doi.org/10.3389/fneur.2016.00212.
Chaudri MB, Liu C, Hubbard R, Jefferson D, Kinnear WJ. Relationship between supramaximal flow during cough and mortality in motor neurone disease. Eur Respir J. 2002;19:434–8.
Morrow B, Zampoli M, van Aswegen H, Argent A. Mechanical insufflation-exsufflation for people with neuromuscular disorders. Cochrane Database Syst Rev. 2013;12(12):CD010044. https://doi.org/10.1002/14651858.cd010044.pub2.
Andersen T, Sandnes A, Brekka AK, Hilland M, Clemm H, Fondenes O, et al. Laryngeal response patterns influence the efficacy of mechanical assisted cough in amyotrophic lateral sclerosis. Thorax. 2017;72(3):221–9.
Andersen T, Sandnes A, Brekka AK, et al. Laryngeal response patterns influence the efficacy of mechanical assisted cough in amyotrophic lateral sclerosis. Thorax. 2016;72:221–9.
Hov B, Andersen T, Toussaint M, Fondenes O, Carlsen KC, Hovland V. Optimizing expiratory flows during mechanical cough in a pediatric neuromuscular lung model. Pediatr Pulmonol. 2019;55:433–40.
Conde B, Martins N, Brandão M, Pimenta AC, Winck JC. Upper airway video endoscopy: assessment of the response to positive pressure ventilation and mechanical in-exsufflation. Pulmonology. 2019;25:299–304.
Dorça A, Sarmet M, Maldaner V. The influence of the non-invasive ventilation mask interface on the upper airway of patients with amyotrophic lateral sclerosis. Pulmonology. 2021;27:359. https://doi.org/10.1016/j.pulmoe.2020.12.002.
Georges M, Attali V, Golmard JL, et al. Reduced survival in patients with ALS with upper airway obstructive events on non-invasive ventilation. J Neurol Neurosurg Psychiatry. 2016;87:1045–50.
Delguste P, Aubert-Tulkens G, Rodenstein DO. Upper airway obstruction during nasal intermittent positive-pressure hyperventilation in sleep. Lancet. 1991;338:1295–7.
Bédard M-E, McKim DA. Daytime mouthpiece for continuous non-invasive ventilation in individuals with amyotrophic lateral sclerosis. Respir Care. 2016;61:1341–8.
Sancho J, Martínez D, Bures E, Díaz JL, Ponz A, Servera E. Bulbar impairment score and survival of stable amyotrophic lateral sclerosis patients after non-invasive ventilation initiation. ERJ Open Res. 2018;4:00159–2017.
Aboussouan LS, Mireles-Cabodevila E. Sleep-disordered breathing in neuromuscular disease. Chest. 2017;152:880–92.
Ferguson KA, Strong MJ, Ahmad D, George CFP. Sleep-disordered breathing in amyotrophic lateral sclerosis. Chest. 1996;110:664–9.
Servera E, Sancho J, Bañuls P, Marín J. Bulbar impairment score predicts non-invasive volume-cycled ventilation failure during an acute lower respiratory tract infection in ALS. J Neurol Sci. 2015;358:87–91.
Dorst J, Ludolph AC. Non-invasive ventilation in amyotrophic lateral sclerosis. Ther Adv Neurol Disord. 2019;12:175628641985704.
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Conde, B., Silva, F.T. (2023). Upper Airway Neuromuscular Disorders and Noninvasive Ventilation. In: Esquinas, A.M., De Vito, A., Barbetakis, N. (eds) Upper Airway Disorders and Noninvasive Mechanical Ventilation. Springer, Cham. https://doi.org/10.1007/978-3-031-32487-1_28
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DOI: https://doi.org/10.1007/978-3-031-32487-1_28
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