Abstract
Deep anterior lamellar keratoplasty (DALK) carries advantages over penetrating keratoplasty (PK) by eliminating donor endothelial rejection and graft decompensation, the leading cause of PK failure. Consequently, DALK in conditions with a healthy host endothelium such as keratoconus improves graft survival. However, DALK is a difficult surgery with a high intraoperative conversion rate to PK due to Descemet membrane (DM) particularly during peripheral DM baring. Through automating stages of DALK with a femtosecond laser to create a 3D mushroom configuration and utilizing a mini big bubble to reduce the area of DM baring to within the confines of the pre-Descemet layer, the risk of intraoperative perforation and conversion to PK can be reduced.
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References
Singh NP, Said DG, Dua HS. Lamellar keratoplasty techniques. Indian J Ophthalmol. 2018;66(9):1239–50.
Brown SI, Dohlman CH, Boruchoff SA. Dislocation Of descemet’s membrane during keratoplasty. Am J Ophthalmol. 1965;60:43–5.
Borderie VM, Sandali O, Bullet J, Gaujoux T, Touzeau O, Laroche L. Long-term results of deep anterior lamellar versus penetrating keratoplasty. Ophthalmology. 2012;119(2):249–55. Feb [cited 2020 Feb 21]. http://www.ncbi.nlm.nih.gov/pubmed/22054997.
Jones MNA, Armitage WJ, Ayliffe W, Larkin DF, Kaye SB, NHSBT Ocular Tissue Advisory Group and Contributing Ophthalmologists (OTAG audit study 5). Penetrating and deep anterior lamellar keratoplasty for keratoconus: a comparison of graft outcomes in the United Kingdom. Invest Ophthalmol Vis Sci. 2009;50(12):5625–9. Dec [cited 2020 Feb 21]. http://www.ncbi.nlm.nih.gov/pubmed/19661238.
Coster DJ, Lowe MT, Keane MC, Williams KA. Australian corneal graft registry contributors. A comparison of lamellar and penetrating keratoplasty outcomes: a registry study. Ophthalmology. 2014;121(5):979–87. http://www.ncbi.nlm.nih.gov/pubmed/24491643.
Ardjomand N, Hau S, McAlister JC, Bunce C, Galaretta D, Tuft SJ, et al. Quality of vision and graft thickness in deep anterior lamellar and penetrating corneal allografts. Am J Ophthalmol. 2007;143(2):228–35.
Keenan TDL, Jones MNA, Rushton S, Carley FM. Trends in the indications for corneal graft surgery in the United Kingdom: 1999 through 2009. Arch Ophthalmol. 2012;130(5):621–8.
Anwar M, Teichmann KD. Deep lamellar keratoplasty: surgical techniques for anterior lamellar keratoplasty with and without baring of descemet’s membrane. Cornea. 2002;21(4):374–83.
Gadhvi KA, Romano V, Fernández-Vega Cueto L, Aiello F, Day AC, Allan BD. Deep anterior lamellar Keratoplasty for keratoconus: multisurgeon results. Am J Ophthalmol. 2019;201:54–62.
Dua HS, Faraj LA, Kenawy MB, AlTaan S, Elalfy MS, Katamish T, et al. Dynamics of big bubble formation in deep anterior lamellar keratoplasty by the big bubble technique: in vitro studies. Acta Ophthalmol. 2018;96(1):69–76.
Dua HS, Faraj LA, Said DG, Gray T, Lowe J. Human corneal anatomy redefined: a novel pre-Descemet’s layer (Dua’s layer). Ophthalmology. 2013;120(9):1778–85.
Farid M, Steinert RF. Deep anterior lamellar keratoplasty performed with the femtosecond laser zigzag incision for the treatment of stromal corneal pathology and ectatic disease. J Cataract Refract Surg. 2009;35(5):809–13.
Price FWJ, Price MO, Grandin JC, Kwon R. Deep anterior lamellar keratoplasty with femtosecond-laser zigzag incisions. J Cataract Refract Surg. 2009;35(5):804–8.
Alio JL, Abdelghany AA, Barraquer R, Hammouda LM, Sabry AM. Femtosecond laser assisted deep anterior lamellar Keratoplasty outcomes and healing patterns compared to manual technique. Biomed Res Int. 2015;2015:1.
Parthasarathy A, Por YM, Tan DTH. Use of a “small-bubble technique” to increase the success of Anwar’s “big-bubble technique” for deep lamellar keratoplasty with complete baring of descemet’s membrane. Br J Ophthalmol. 2007;91(10):1369–73.
Shimmura S, Shimazaki J, Omoto M, Teruya A, Ishioka M, Tsubota K. Deep lamellar keratoplasty (DLKP) in keratoconus patients using viscoadaptive viscoelastics. Cornea. 2005;24(2):178–81.
Salouti R, Zamani M, Ghoreyshi M, Dapena I, Melles GRJ, Nowroozzadeh MH. Comparison between manual trephination versus femtosecond laser-assisted deep anterior lamellar keratoplasty for keratoconus. Br J Ophthalmol. 2019;103(12):1716–23.
Buzzonetti L, Petrocelli G, Valente P, Iarossi G, Ardia R, Petroni S, et al. The big-bubble full femtosecond laser-assisted technique in deep anterior lamellar Keratoplasty. J Refract Surg. 2015;31(12):830–4.
Liu Y-C, Wittwer VV, Yusoff NZM, Lwin CN, Seah XY, Mehta JS, et al. Intraoperative optical coherence tomography-guided femtosecond laser-assisted deep anterior lamellar keratoplasty. Cornea. 2019;38(5):648–53.
Gadhvi KA, Romano V, Fernández-Vega Cueto L, Aiello F, Day AC, Gore DM, et al. Femtosecond laser-assisted deep anterior lamellar Keratoplasty for keratoconus: multi-surgeon results. Am J Ophthalmol. 2020;220:191–202.
Espandar L, Mandell JB, Niknam S. Femtosecond laser-assisted decagonal deep anterior lamellar keratoplasty. Can J Ophthalmol. 2016;51(2):67–70.
Boden KT, Schlosser R, Boden K, Januschowski K, Szurman P, Rickmann A. Novel liquid Interface for femtosecond laser-assisted penetrating Keratoplasty. Curr Eye Res. 2020;45(9):1051–7.
Donner R, Schmidinger G. Effects of femtosecond laser-assisted trephination on donor tissue in liquid interface as compared to applanated interface. Acta Ophthalmol. 2022;100(2):e409–13.
Tóth G, Szentmáry N, Langenbucher A, Akhmedova E, El-Husseiny M, Seitz B. Comparison of excimer laser versus femtosecond laser assisted trephination in penetrating Keratoplasty: a retrospective study. Adv Ther. 2019;36(12):3471–82.
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Here is a video of a Femto DALK procedure being performed using the mini big bubble technique described in this chapter (MP4 175106 kb)
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Gadhvi, K.A., Allan, B.D. (2023). Advanced DALK Techniques: Mushroom Mini Big Bubble DALK. In: Alió, J.L., del Barrio, J.L.A. (eds) Modern Keratoplasty. Essentials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-031-32408-6_22
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