Abstract
The incorporation of prior knowledge into a medical segmentation task allows to compensate for the issue of weak boundary definition and to be more in line with anatomical reality even though the data do not explicitly show these characteristics. This motivation underlies the proposed contribution which aims to provide a unified variational framework involving topological requirements in the training of convolutional neural networks through the design of a suitable penalty in the loss function. More precisely, these topological constraints are implicitly enforced by viewing the segmentation assignment as a registration task between the considered image and its associated ground truth under incompressibility condition, making them homeomorphic. The application falls within the scope of organ-at-risk segmentation in CT (Computed Tomography) images, in the context of radiotherapy planning.
This project was co-financed by the European Union with the European regional development fund (ERDF, 18P03390/18E01750/18P02733), by the Haute-Normandie Régional Council via the M2SINUM project and by the French Research National Agency ANR via AAP CE23 MEDISEG ANR project. The authors would like to thank the CRIANN (Centre Régional Informatique et d’Applications Numériques de Normandie, France) for providing computational resources.
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References
Ball, J.M.: Global invertibility of Sobolev functions and the interpenetration of matter. P. Roy. Soc. Edin. A 88(3–4), 315–328 (1981)
Ciarlet, P.: Three-Dimensional Elasticity. Elsevier Science, Mathematical Elasticity (1994)
Clough, J., Byrne, N., Oksuz, I., Zimmer, V.A., Schnabel, J.A., King, A.: Topological loss function for deep-learning based image segmentation using persistent homology. IEEE Trans. Pattern Anal. Mach. Intell. (2020). IEEE
Edelsbrunner, H., Harer, J.L.: Computational Topology: An Introduction. American Mathematical Society (2010)
El Jurdi, R., Petitjean, C., Honeine, P., Cheplygina, V., Abdallah, F.: High-level prior-based loss functions for medical image segmentation: A survey. Comput. Vis. Image Underst. 210, 103248 (2021)
Estienne, T., et al.: U-ReSNet: ultimate coupling of registration and segmentation with deep nets. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11766, pp. 310–319. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32248-9_35
Fischl, B., Liu, A., Dale, A.M.: Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans. Med. Imaging 20(1), 70–80 (2001)
Glorot, X., Bengio, Y.: Understanding the difficulty of training deep feedforward neural networks. In: Proceedings of the Thirteenth International Conference on Artificial Intelligence and Statistics, pp. 249–256 (2010)
Glowinski, R., Le Tallec, P.: Numerical solution of problems in incompressible finite elasticity by augmented Lagrangian methods. I. Two-dimensional and axisymmetric problems. SIAM J. Appl. Math. 42(2), 400–429 (1982)
Hu, X., Li, F., Samaras, D., Chen, C.: Topology-preserving deep image segmentation. Adv. Neural Inf. Process. Syst. 32 (2019)
Lambert, Z., Petitjean, C., Dubray, B., Ruan, S.: SegTHOR: Segmentation of Thoracic Organs at Risk in CT images. In: 2020 Tenth International Conference on Image Processing Theory, Tools and Applications (IPTA), pp. 1–6 (2020)
Li, B., et al.: A hybrid deep learning framework for integrated segmentation and registration: evaluation on longitudinal white matter tract changes. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11766, pp. 645–653. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32248-9_72
Liu, J., Wang, X., Tai, X.C.: Deep Convolutional Neural Networks with Spatial Regularization, Volume and Star-shape Priori for Image Segmentation. J. Math. Imaging Vis. 64(6), 625–645 (2022)
Negrón Marrero, P.: A numerical method for detecting singular minimizers of multidimensional problems in nonlinear elasticity. Numer. Math. 58, 135–144 (1990)
Ségonne, F., Pacheco, J., Fischl, B.: Geometrically Accurate Topology-Correction of Cortical Surfaces Using Nonseparating loops. IEEE Trans. Med. Imaging 26(4), 518–529 (2007)
Shit, S.: clDice-a novel topology-preserving loss function for tubular structure segmentation. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 16560–16569 (2021)
Wirth, B.: On the Gamma-limit of joint image segmentation and registration functionals based on phase fields. Interfaces Free Bound. 18(4), 441–477 (2016)
Xu, Z., Niethammer, M.: DeepAtlas: joint semi-supervised learning of image registration and segmentation. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11765, pp. 420–429. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32245-8_47
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Lambert, Z., Le Guyader, C., Petitjean, C. (2023). On the Inclusion of Topological Requirements in CNNs for Semantic Segmentation Applied to Radiotherapy. In: Calatroni, L., Donatelli, M., Morigi, S., Prato, M., Santacesaria, M. (eds) Scale Space and Variational Methods in Computer Vision. SSVM 2023. Lecture Notes in Computer Science, vol 14009. Springer, Cham. https://doi.org/10.1007/978-3-031-31975-4_28
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