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Overview and Historical Perspective of Preimplantation Genetic Testing

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Prenatal Diagnostic Testing for Genetic Disorders

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Abstract

Preimplantation genetic testing (PGT) began in 1968 when Gardner and Edwards [1] biopsied a rabbit blastocyst to perform X-chromatin analysis. The ultimate goal was to detect male embryos that would be excluded if at risk for X-linked recessive traits. However, not until human in vitro fertilization (IVF) was achieved in 1978, by Steptoe and Edwards [2], did applications to humans become imaginable. In that era, the methodology was known as preimplantation genetic diagnosis (PGD).

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Authors and Affiliations

  1. Department of Human and Molecular Genetics, Florida International University, Miami, FL, USA

    Joe Leigh Simpson, Svetlana Rechitsky & Anver Kuliev

  2. Department of Obstetrics and Gynecology, Florida International University, Miami, FL, USA

    Joe Leigh Simpson

  3. Reproductive Genetic Innovations, Chicago, IL, USA

    Joe Leigh Simpson, Svetlana Rechitsky & Anver Kuliev

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  1. Joe Leigh Simpson
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  2. Svetlana Rechitsky
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  3. Anver Kuliev
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Correspondence to Joe Leigh Simpson .

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Editors and Affiliations

  1. Centre for Perinatal & Reproductive Medicine, University of Perugia, Perugia, Umbria, Italy

    Gian Carlo Di Renzo

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Simpson, J.L., Rechitsky, S., Kuliev, A. (2023). Overview and Historical Perspective of Preimplantation Genetic Testing. In: Di Renzo, G.C. (eds) Prenatal Diagnostic Testing for Genetic Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-31758-3_26

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  • DOI: https://doi.org/10.1007/978-3-031-31758-3_26

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