Abstract
Obstructions of the seminal ducts affect epididymis, ductus deferens, and ductus ejaculatorius. Bilateral obstruction causes azoospermia with usually normal testicular volume, FSH, and inhibin B. Causes of obstruction are varied and include congenital disease, infection, trauma, intentional or accidental surgical sequelae, and functional disorders. Surgical sperm retrieval followed by assisted reproduction may be offered in cases of an unfulfilled desire for a child with no causal therapeutic option. Cystic fibrosis is associated with obstructive azoospermia in most affected men. Congenital bilateral aplasia of the ductus deferens (CBAVD) is also genetic in most cases. In both conditions, genetic counseling and diagnostic testing of the couple is strongly recommended before performing assisted reproduction procedures.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cihanbeylerden M, Kurt B (2022) Young’s syndrome, a rare syndrome that can cause infertility and mimics cystic fibrosis and immotile-cilia syndrome: a case report. Eur Rev. Med Pharmacol Sci 26:6569–6571
von Eckardstein S, Cooper TG, Rutscha K, Meschede D, Horst J, Nieschlag E (2000) Seminal plasma characteristics as indicators of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in men with obstructive azoospermia. Fertil Steril 73:1226–1231
Handelsman DJ, Conway AJ, Boylan LM, Turtle JR (1984) Young’s syndrome. Obstructive azoospermia and chronic sinopulmonary infections. N Engl J Med 310:3–9
Kirchhoff C (2018) Genetische Heterogenität der angeborenen Samenleiteraplasie. J Reproduktionsmed Endokrinol 15:136–142
Meschede D, Dworniczak B, Behre HM, Kliesch S, Claustres M, Nieschlag E, Horst J (1997) CFTR gene mutations in men with bilateral ejaculatory-duct obstruction and anomalies of the seminal vesicles. Am J Hum Genet 61:1200–1202
Mukoviszidose (2022). https://www.muko.info/. Accessed 27 Dec 2022.
Patat O, Pagin A, Siegfried A, Mitchell V, Chassaing N, Faguer S, Monteil L, Gaston V, Bujan L, Courtade-Saïdi M, Marcelli F, Lalau G, Rigot JM, Mieusset R, Bieth E (2016) Truncating mutations in the adhesion G protein-coupled receptor G2 gene ADGRG2 cause an X-linked congenital bilateral absence of vas deferens. Am J Hum Genet 99:437–442
Rudnik-Schöneborn S, Messner M, Vockel M, Wirleitner B, Pinggera GM, Witsch-Baumgartner M, Murtinger M, Kliesch S, Swoboda M, Sänger N, Zschocke J, Tüttelmann F (2021) Andrological findings in infertile men with two (biallelic) CFTR mutations: results of a multicentre study in Germany and Austria comprising 71 patients. Hum Reprod 36:551–559
Salonia A, Bettocchi C, Carvalho J, Corona G, Jones TH, Kadioglu A, Martinez-Salamanca JI, Minhas S, Serefoglu EC, Verze P (2022) EAU Guidelines on Sexual and Reproductive Health. EAU Guidelines Office, Arnhem, The Netherlands. http://uroweb.org/guidelines/compilations-of-all-guidelines/. Accessed 20 Dec 2022.
Savant A, Lyman B, Bojanowski C, Upadia J (2022) Cystic fibrosis. In: Adam MP, Everman CB, Mirzaa GM, Pagon RA, Wallace SE (eds) GeneReviews. University of Washington, Seattle, WA. https://www.ncbi.nlm.nih.gov/books/NBK1116/. Accessed 27 Dec 2022.
Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, Lamb DJ, Mulhall JP, Niederberger C, Sandlow JI, Sokol RZ, Spandorfer SD, Tanrikut C, Treadwell JR, Oristaglio JT, Zini A (2021a) Diagnosis and treatment of infertility in men: AUA/ASRM guideline part I. Fertil Steril 115:54–61
Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, Lamb DJ, Mulhall JP, Niederberger C, Sandlow JI, Sokol RZ, Spandorfer SD, Tanrikut C, Treadwell JR, Oristaglio JT, Zini A (2021b) Diagnosis and treatment of infertility in men: AUA/ASRM guideline part II. Fertil Steril 115:62–69
Schmitt-Grohé S, Lentze MJ, Henker J (2019) Zystische Fibrose (Mukoviszidose) im Kindes- und Jugendalter. In: Hoffmann G, Lentze M, Spranger J, Zepp F, Berner R (eds) Pädiatrie. Springer Reference Medizin. Springer, Berlin. https://doi.org/10.1007/978-3-642-54671-6_187-2
Tüttelmann F, Werny F, Cooper TG, Kliesch S, Simoni M, Nieschlag E (2011) Clinical experience with azoospermia: aetiology and chances for spermatozoa detection upon biopsy. Int J Androl 34:291–298
Wyrwoll MJ, Köckerling N, Vockel M, Dicke AK, Rotte N, Pohl E, Emich J, Wöste M, Ruckert C, Wabschke R, Seggewiss J, Ledig S, Tewes AC, Stratis Y, Cremers JF, Wistuba J, Krallmann C, Kliesch S, Röpke A, Stallmeyer B, Friedrich C, Tüttelmann F (2022) Genetic architecture of azoospermia-time to advance the standard of care. Eur Urol 83(5):452–462. https://doi.org/10.1016/j.eururo.2022.05.011
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Behre, H.M., Kliesch, S., Tüttelmann, F., Behre, B. (2023). Obstructions of the Seminal Ducts, Cystic Fibrosis, and Congenital Aplasia of the Ductus Deferens. In: Nieschlag, E., Behre, H.M., Kliesch, S., Nieschlag, S. (eds) Andrology. Springer, Cham. https://doi.org/10.1007/978-3-031-31574-9_27
Download citation
DOI: https://doi.org/10.1007/978-3-031-31574-9_27
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-31573-2
Online ISBN: 978-3-031-31574-9
eBook Packages: MedicineMedicine (R0)