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Acute Reaction to Red Cells: What Lies Beneath?

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Transfusion Medicine

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Abstract

This chapter describes an acute reaction occurring during transfusion of red cells. Several serious, potentially lethal, transfusion-related complications are discussed: transfusion of ABO-incompatible blood, bacterial contamination of blood products, anaphylactic reaction, and transfusion-associated pulmonary complications, all of which can initially present in a similar manner. Contamination of blood products with bacteria is described, as well as pathogen inactivation methods.

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References

  1. Narayan S. editor. Poles D et al. on behalf of the serious hazard of transfusion (SHOT) steering group. The 2020 annual SHOT report 2021.

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  2. Pathogen inactivation of platelets: report of the SaBTO working group. Apr 2014. www.gov.uk/government/publications/platelet-transfusion-infection-risk-review

  3. Allain JP, Owusu-Ofori AK, Assenato SM, et al. Effect of Plasmodium inactivation in whole blood on the incidence of blood transfusion-transmitted malaria in endemic regions: the African Investigation of the Mirasol System (AIMS) randomized controlled trial. Lancet. 2016;387:1753–61.

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Further Reading

  1. McCullough J. Pathogen reduced blood products. In: McCullough J, Transfusion Medicine, 5th ed. Wiley Blackwell, pp. 359–75.

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Authors and Affiliations

  1. King’s College Hospital, London, SE5 9RS, UK

    Aleksandar Mijovic

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  1. Aleksandar Mijovic
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Correspondence to Aleksandar Mijovic .

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Editors and Affiliations

  1. Haematology, King's College Hospital, London, UK

    Aleksandar Mijovic

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Cite this chapter

Mijovic, A. (2023). Acute Reaction to Red Cells: What Lies Beneath?. In: Mijovic, A. (eds) Transfusion Medicine. Springer, Cham. https://doi.org/10.1007/978-3-031-31462-9_7

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  • DOI: https://doi.org/10.1007/978-3-031-31462-9_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-31461-2

  • Online ISBN: 978-3-031-31462-9

  • eBook Packages: MedicineMedicine (R0)

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