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The Origin, Evolution and History of Leprosy Through a Palaeopathological Lens

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Hansen’s Disease

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Abstract

Leprosy has a long history as seen through historical evidence, and evidence in skeletons from archaeological sites that is several thousand years old. This section highlights the methods used to identify leprosy, reveals the bone changes of leprosy affecting the facial, hand and foot bones that are recognized by palaeopathologists, focuses on the global evidence for leprosy according to time and place, and shows how ancient DNA analysis of M. leprae is providing new insights on its origin, evolution and history.

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References

  1. Rawcliffe C. Leprosy in medieval England. Woodbridge: Boydell Press; 2006.

    Google Scholar 

  2. Roberts CA, Manchester K. The archaeology of disease. 3rd ed. Gloucester: Sutton Publishing; 2005.

    Google Scholar 

  3. Buikstra JE. Ortner’s identification of pathological conditions in human skeletal remains. London: Academic Press; 2019a.

    Google Scholar 

  4. Roberts CA, Scollard DM, Fava VM. The origin, evolution of tuberculosis from clinical, genetic and palaeopathological perspectives. In: Plomp K, Roberts CA, Elton S, Bentley G, editors. Palaeopathology and evolutionary medicine: an integrated approach. Oxford: Oxford University Press; 2022.

    Google Scholar 

  5. Resnick D, editor. Diagnosis of bone and joint disorders. London: W.B. Saunders; 2002.

    Google Scholar 

  6. Buikstra JE. A brief history and 21st century challenges. In: Buikstra JE, editor. Ortner’s identification of pathological conditions in human skeletal remains. London: Academic Press; 2019b. p. 11–9.

    Chapter  Google Scholar 

  7. Wood JW, Milner GR, Harpending HC, Weiss KM. The osteological paradox: problems of inferring prehistoric health from skeletal samples. Curr Anthropol. 1992;33:343–70.

    Article  Google Scholar 

  8. Lambert PM. Ethics and issues in the use of skeletal remains in paleopathology. In: Grauer AL, editor. A companion to paleopathology. Cambridge: Cambridge University Press; 2012. p. 17–33.

    Google Scholar 

  9. Cohen M, Armelagos G, editors. Palaeopathology at the origins of agriculture. Academic Press: London; 1984.

    Google Scholar 

  10. Newman SL, Gowland RL, Caffell AC. North and south: a comprehensive analysis of non-adult growth and health in the industrial revolution (AD 18th–19th C), England. Am J Biol Anthropol. 2019;169(1):104–21. https://doi.org/10.1002/ajpa.23817.

    Article  Google Scholar 

  11. Paterson DE, Rad M. Bone changes of leprosy: their incidence, progress, prevention and arrest. Int J Lepr Other Mycobact Dis. 1961;29:393–422.

    CAS  Google Scholar 

  12. Ridley DS, Jopling WH. Classification of leprosy according to immunity: a five-group system. Int J Lepr Other Mycobact Dis. 1966;34:255–73.

    CAS  PubMed  Google Scholar 

  13. Matos VMJ. The retrospective diagnosis of leprosy: clinical and paleopathological complementarities in the medical files from the Rovisco Pais Hospital-Colony (20th Century, Tocha, Portugal) and in the skeletal collection from the medieval leprosarium of St. Jorgen’s (Odense, Denmark). Coimbra: Universidade de Coimbra; 2009.

    Google Scholar 

  14. Møller-Christensen V. Bone changes in leprosy. Copenhagen: Munksgaard; 1961.

    Google Scholar 

  15. Andersen JG. Studies in the mediaeval diagnosis of leprosy in Denmark. Copenhagen: Costers Bogtrykkeri; 1969.

    Google Scholar 

  16. Roberts CA. Leprosy. Past and present. Gainesville: University of Florida Press; 2020.

    Book  Google Scholar 

  17. Boldsen JL. Epidemiological approach to the paleopathological diagnosis of leprosy. Am J Phys Anthropol. 2001;115(4):380–7.

    Article  CAS  PubMed  Google Scholar 

  18. Hagelberg E, Sykes B, Hedges R. Ancient bone DNA amplified. Nature. 1989;342:485.

    Article  CAS  PubMed  Google Scholar 

  19. Rafi A, Spigelman M, Stanford J, Lemma E, Donoghue H, Zias J. DNA of Mycobacterium leprae detected by PCR in ancient bone. Int J Osteoarchaeol. 1994;4:287–90.

    Article  Google Scholar 

  20. Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, Wheeler PR, Honor N, Garnier T, Churcher C, Harris D, et al. Massive gene decay in leprosy bacillus. Nature. 2001;409:1007–11.

    Article  CAS  PubMed  Google Scholar 

  21. Singh P, Benjak A, Schuenemann VJ, Herbig A, Avanzi C, Busso P, Nieselt K, Krause J, Vera-Cabrera L, Cole ST. Insight into the evolution and origin of leprosy bacilli from the genome sequence of Mycobacterium lepromatosis. Proc Natl Acad Sci USA. 2015;112:4459–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Schuenemann VJ, Singh P, Mendum TA, Krause-Kyora B, Jager G, Bos KI, Herbig A, Economou C, Benjak A, Busso P, et al. Genome-wide comparison of medieval and modern Mycobacterium leprae. Science. 2013;341:179–83.

    Article  CAS  PubMed  Google Scholar 

  23. Fotakis AK, Denham SD, Mackie M, Orbegozo MI, Mylopotamitaki D, Gopalakrishnan S, Sicheritz-Pontén T, Olsen JV, Cappellini E, Zhang G, Christophersen A, Gilbert MTP, Vågene AJ. Multi-omic detection of Mycobacterium leprae in archaeological human dental calculus. Philos Trans R Soc B. 2020;375:20190584.

    Article  CAS  Google Scholar 

  24. Monot M, Honor N, Garnier MT, Arao R, Copp J-Y, Lacroix C, Sow S, Spencer JS, Truman RW, Williams DL, et al. On the origin of leprosy. Science. 2005;308(5724):1040–2.

    Article  CAS  PubMed  Google Scholar 

  25. Monot M, Honor N, Garnier MT, Zidane N, Sherafi D, Paniz-Mondolfi A, Matsuoka M, Taylor GM, Donoghue HD, Bouwman A, et al. Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nat Genet. 2009;41:1282–9.

    Article  CAS  PubMed  Google Scholar 

  26. Taylor GM, Tucker K, Butler R, Pike AW, Lewis J, Roffey S, Marter P, Lee O-Y, Wu HH, Minnikin DE, Besra GS, et al. Detection and strain typing of ancient Mycobacterium leprae from a medieval leprosy hospital. PLoS One. 2013;8(4):e62406. https://doi.org/10.1371/journal.pone.0062406.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Economou C, Kjellstrom A, Lidén K, Panagopoulos I. Ancient-DNA reveals an Asian type of Mycobacterium leprae in medieval Scandinavia. J Archaeol Sci. 2013;40:465–70.

    Article  CAS  Google Scholar 

  28. Donoghue HD, Taylor GM, Marcsik A, Molnár E, Pálfi G, Pap I, Teschler-Nicola M, Pinhasi R, Erdal YS, Velemínsky P, et al. A migration-driven model for the historical spread of leprosy in medieval eastern and Central Europe. Infect Genet Evol. 2015;31:250–6.

    Article  PubMed  Google Scholar 

  29. Schuenemann VJ, Avanzi C, Krause-Kyora B, Seitz A, Herbig A, Inskip S, Bonazzi M, Reiter E, Urban C, Pedersen DD, et al. Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe. PLoS Pathog. 2018;14(5):e1006997.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Pfrengle S, Neukamm J, Guellil M, Keller M, Molak M, Avanzi C, Kushniarevich A, Montes N, Neumann G, Tukhbatova RI, Berezina NY, Buzhilova AP, Sergeevich KD, Hamre SS, Matos V, Ferreira MT, González-Garrido L, Wasterlain SN, Lopes C, Santos AL, Antunes-Ferreira N, Duarte V, Silva AM, Melo L, Sarkic N, Saag L, Tambets K, Reiter E, Busso P, Cole ST, Roberts CA, Sheridan A, Cessford C, Robb J, Krause J, Scheib CL, Inskip SA, Schuenemann VJ. Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes. BMC Biol. 2021;19:220. https://doi.org/10.1186/s12915-021-01120-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Magilton J, Lee F, Boylston A, editors. ‘Lepers outside the gate’. Excavations at the cemetery of the Hospital of St James and St Mary Magdalene, Chichester, 1986–1987 and 1993. York: Council for British Archaeology Research Report 158/Chichester Excavations 10; 2008.

    Google Scholar 

  32. Roffey S, Tucker K. A contextual study of the medieval hospital and cemetery of St Mary Magdalen, Winchester, England. Int J Paleopathol. 2012;2:170–80.

    Article  PubMed  Google Scholar 

  33. Møller-Christensen V. Changes in the maxillary bone with leprosy. Int J Lepr Other Mycobact Dis. 1953;21:616–7.

    Google Scholar 

  34. Manchester K. Tuberculosis and leprosy in antiquity: an interpretation. Med Hist. 1984;28:162–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Roffey S, Tucker K, Filipek-Ogden K, Montgomery J, Cameron J, O’Connell T, Evans J, Marter P, Taylor GM. Investigation of a medieval pilgrim burial excavated from the leprosarium of St Mary Magdalen Winchester, UK. PLoS Negl Trop Dis. 2017;11(1):e0005186. https://doi.org/10.1371/journal.pntd.0005186.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Avanzi C, Del-Pozo J, Benjak A, Stevenson K, Simpson VR, Busso P, McLuckie J, Loiseau C, Lawton C, Schoening J, et al. Red squirrels in the British Isles are infected with leprosy bacilli. Science. 2016;354(6313):744–7.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Archaeology, Durham University, Durham, UK

    Charlotte A. Roberts

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  1. Charlotte A. Roberts
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Correspondence to Charlotte A. Roberts .

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  1. Social Medicine Department, Universidade Federal do Espírito Santo, Vitória, Brazil

    Patrícia D. Deps

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Roberts, C.A. (2023). The Origin, Evolution and History of Leprosy Through a Palaeopathological Lens. In: Deps, P.D. (eds) Hansen’s Disease. Springer, Cham. https://doi.org/10.1007/978-3-031-30893-2_3

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  • DOI: https://doi.org/10.1007/978-3-031-30893-2_3

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-031-30893-2

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