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Ophthalmological Alterations in Hansen’s Disease

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Hansen’s Disease

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Abstract

Hansen’s disease is the systemic disease that most affects the eyes and their annexes. Recognizing these alterations for early diagnosis and adequate treatment is fundamental to avoid blindness caused by the disease.

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References

  1. Joffrion VC. Ocular Leprosy. In: Hastings RC, Opromolla DVA, editors. Leprosy. 2nd ed. Edinburgh: Churchill Livingstone; 1994. p. 353–65.

    Google Scholar 

  2. Courtright P, Daniel E, Sundarrao RJ, Mengistu F, Belachew M, Celloria RV, Ffytche T. Eye disease in multibacillary leprosy patients at the time of their leprosy diagnosis: findings from the longitudinal study of ocular leprosy (LOSOL) in India, The Philippines an Ethiopia. Lepr Rev. 2002;73:225–38.

    Article  CAS  PubMed  Google Scholar 

  3. Daniel E, Ffytche TJ, Kempen JH, Rao PS, Diener-West M, Courtright P. Incidence of ocular complications in patients with multibacillary leprosy after completion of a 2 year course of multidrug therapy. Br J Ophthalmol. 2006;90(8):949–54. https://doi.org/10.1136/bjo.2006.094870. Daniel E, Ffytche TJ, Kempen JH, et al. Incidence of ocular complications in patients with multibacillary leprosy after completion of a 2 year course of multidrug therapy. Br J Ophthalmol 2006; 90:949

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Lewallen S, Tungpakorn NC, Kim SH, Courtright P. Progression of eye disease in "cured" leprosy patients: implications for understanding the pathophysiology of ocular disease and for addressing eyecare needs. Br J Ophthalmol. 2000;84(8):817–21. https://doi.org/10.1136/bjo.84.8.817.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Srinivas G, Muthuvel T, Lal V, Vaikundanathan K, Schwienhorst-Stich EM, Kasang C. Risk of disability among adult leprosy cases and determinants of delay in diagnosis in five states of India: a case-control study. PLoS Negl Trop Dis. 2019;13(6):e0007495. Published 2019 Jun 27. https://doi.org/10.1371/journal.pntd.0007495.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Citirik M, Batman C, Aslan O, Adabag A, Ozalp S, Zilelioglu O. Lepromatous iridocyclitis. Ocul Immunol Inflamm. 2005;13(1):95–9. https://doi.org/10.1080/09273940490912380.

    Article  PubMed  Google Scholar 

  7. Daniel E, Koshy S, Rao GS, Sundar Rao PS. Ocular complications in newly diagnosed borderline lepromatous and lepromatous leprosy patients: baseline profile of the Indian cohort. Br J Ophthalmol. 2002;86:1336–40.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Chen X, Zha S, Shui TJ. Presenting symptoms of leprosy at diagnosis: clinical evidence from a cross-sectional, population-based study. PLoS Negl Trop Dis. 2021;15(11):e0009913. Published 2021 Nov 23. https://doi.org/10.1371/journal.pntd.0009913.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Waddell KM, Saunderson PR. Is leprosy blindness avoidable? The effect of disease type, duration, and treatment on eye damage from leprosy in Uganda. Br J Ophthalmol. 1995;79(3):250–6. https://doi.org/10.1136/bjo.79.3.250.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Nunzi E, Massone C. Leprosy: a practical guide. Milano: Spinger; 2012.

    Book  Google Scholar 

  11. Shamsi FA, Chaudhry IA, Moraes MO, Martinez AN, Riley FC. Detection of mycobacterium leprae in ocular tissues by histopathology and real-time polymerase chain reaction. Ophthalmic Res. 2007;39(2):63–8. https://doi.org/10.1159/000099375.

    Article  PubMed  Google Scholar 

  12. Cardozo AV, Deps P, Antunes JM, Belone Ade F, Rosa PS. Mycobacterium leprae in ocular tissues: histopathological findings in experimental leprosy. Indian J Dermatol Venereol Leprol. 2011;77(2):252–3. https://doi.org/10.4103/0378-6323.77490.

    Article  PubMed  Google Scholar 

  13. Malik AN, Morris RW, Ffytche TJ. The prevalence of ocular complications in leprosy patients seen in the United Kingdom over a period of 21 years. Eye (Lond). 2011;25(6):740–5. https://doi.org/10.1038/eye.2011.43.

    Article  CAS  PubMed  Google Scholar 

  14. Daniel E, Sundar Rao PS, Ffytche TJ, Chacko S, Prasanth HR, Courtright P. Iris atrophy in patients with newly diagnosed multibacillary leprosy: at diagnosis, during and after completion of multidrug treatment. Br J Ophthalmol. 2007;91(8):1019–22. Epub 2006 Nov 15

    Article  PubMed  Google Scholar 

  15. Rathinam SR, Khazaei HM, Job CK. Histopathological study of ocular erythema nodosum leprosum and post-therapeutic scleral perforation: a case report. Indian J Ophthalmol. 2008;56(5):417–9. https://doi.org/10.4103/0301-4738.42421.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Iraha S, Kondo S, Yamaguchi T, Inoue T. Bilateral corneal perforation caused by neurotrophic keratopathy associated with leprosy: a case report. BMC Ophthalmol. 2022;22(1):42.

    Article  PubMed Central  PubMed  Google Scholar 

  17. Soomro FR, Pathan GM. Ocular disabilities in leprosy, Larkana District, Sindh, Pakistan. J Pak Assoc Dermatol. 2007;17:11–3.

    Google Scholar 

  18. Roldan-Vasquez A, Roldan-Vasquez E, Vasquez AM. Uveitic glaucoma and Hansen's disease, a case report. Am J Ophthalmol Case Rep. 2021;22:101096.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Wroblewski KJ, Hidayat A, Neafie R, Meyers W. The AFIP history of ocular leprosy. Saudi J Ophthalmol. 2019;33(3):255–9. https://doi.org/10.1016/j.sjopt.2019.09.003.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Mvogo CE, Bella-Hiag AL, Ellong A, Achu JH, Nkeng PF. Ocular complications of leprosy in Cameroon. Acta Ophthalmol Scand. 2001;79(1):31–3. https://doi.org/10.1034/j.1600-0420.2001.079001031.x.

    Article  CAS  PubMed  Google Scholar 

  21. El Toukhy E. Gold weight implants in the management of lagophthalmos in leprosy patients. Lepr Rev. 2010;81(1):79–81. PMID: 20496572

    Article  PubMed  Google Scholar 

  22. Wagenaar I, Post E, Brandsma W, Bowers B, Alam K, Shetty V, et al. Effectiveness of 32 versus 20 weeks of prednisolone in leprosy patients with recent nerve function impairment: A randomized controlled trial. PLoS Negl Trop Dis. 2017;11(10):e0005952. Published 2017 Oct 4. https://doi.org/10.1371/journal.pntd.0005952.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Pavezzi PD, do Prado RB, Boin Filho PÂ, AdS G, Tuma B, Fornazieri MA, et al. Evaluation of ocular involvement in patients with Hansen’s disease. PLoS Negl Trop Dis. 2020;14(9):e0008585. https://doi.org/10.1371/journal.pntd.0008585.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Mukhopadhyay S, Sen S, Datta H. Comparative role of 20% cord blood serum and 20% autologous serum in dry eye associated with Hansen's disease: a tear proteomic study. Br J Ophthalmol. 2014;99(1):108–12. added to CENTRAL: 28 February 2015|2015 Issue

    Article  PubMed  Google Scholar 

  25. Kaushik J, Jain VK, Parihar JKS, Dhar S, Agarwal S. Leprosy presenting with Iridocyclitis: a diagnostic dilemma. J Ophthalmic Vis Res. 2017;12(4):437–9. https://doi.org/10.4103/jovr.jovr_155_15.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Lana-Peixoto MA, Campos WR, Reis PA, Campos CM, Rodrigues CA. Tonic pupil in leprosy. Arq Bras Oftalmol. 2014;77(6):395–6. https://doi.org/10.5935/0004-2749.20140098.

    Article  PubMed  Google Scholar 

  27. Morais LNA, David JPF, Peres Lima JV, Demachki S, Diniz DG, Almeida EF. Acquired acoria and iris pearls in leprosy: Case report. Eur J Ophthalmol. 2021;32(6):NP36–40. https://doi.org/10.1177/11206721211024057.

    Article  PubMed  Google Scholar 

  28. Lewallen S, Courtright P, Lee HS. Ocular autonomic dysfunction and intraocular pressure in leprosy. Br J Ophthalmol. 1989;73(12):946–9. https://doi.org/10.1136/bjo.73.12.946.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Brandt F, Malla OK, Anten JG. Influence of untreated chronic plastic iridocyclitis on intraocular pressure in leprous patients. Br J Ophthalmol. 1981;65(4):240–2. https://doi.org/10.1136/bjo.65.4.240.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Choyce DP. The diagnosis and management of ocular leprosy. Br J Ophthalmol. 1969;53(4):217–23.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  31. Ebenezer GJ, Daniel E. Expression of protein gene product 9.5 in lepromatous eyes showing ciliary body nerve damage and a “dying back” phenomenon in the posterior ciliary nerves. Br J Ophthalmol. 2004;88(2):178–81. https://doi.org/10.1136/bjo.2003.027276.

  32. Manabe S, Bucala R, Cerami A. Nonenzymatic addition of glucocorticoids to lens proteins in steroid-induced cataracts. J Clin Invest. 1984;74(1):803.

    Google Scholar 

  33. Chen HS, Wu ZM, Chen Y, He MS, Lin ZD. Clinical research of phacoemulsification with intraocular lens implantation in the treatment of cataract in leprosy patients. Int J Ophthalmol. 2015;15(10):1814–6. added to CENTRAL: 31 January 2016|2016 Issue 1

    Google Scholar 

  34. Barot RK, Viswanath V, Pattiwar MS, Torsekar RG. Crystalline deposition in the cornea and conjunctiva secondary to long-term clofazimine therapy in a leprosy patient. Indian J Ophthalmol. 2011;59:328–9.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Font RL, Sobol W, Matoba A. Polychromatic corneal and conjunctival crystals secondary to clofazimine therapy in leper. Ophthalmology. 1989;96:311–5.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Secretaria Estadual de Saúde, Vitória, Brazil

    Adriana Vieira Cardozo

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  1. Adriana Vieira Cardozo
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  1. Social Medicine Department, Universidade Federal do Espírito Santo, Vitória, Brazil

    Patrícia D. Deps

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Cardozo, A.V. (2023). Ophthalmological Alterations in Hansen’s Disease. In: Deps, P.D. (eds) Hansen’s Disease. Springer, Cham. https://doi.org/10.1007/978-3-031-30893-2_15

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  • DOI: https://doi.org/10.1007/978-3-031-30893-2_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-30892-5

  • Online ISBN: 978-3-031-30893-2

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