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New Molecular Mechanisms of Virulence and Pathogenesis in E. coli

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Trending Topics in Escherichia coli Research

Chapter Summary

The rapid progress in diverse approaches and technologies such as genome sequencing, gene mutation, site-directed mutagenesis, proteomics, crystallography, high-throughput screening and cryo-electron microscopy has provided unprecedented knowledge regarding novel functions during E. coli pathogenesis. In this chapter, we discuss six novel mechanisms of virulence and pathogenesis into the different E. coli pathotypes. These mechanisms include two nanomachines (T3SS and T6SS) used to colonize and hijack the host cell functions (T3SS, T6SS) or for bacterial competition (T6SS), as well as the mechanisms of T3SS protein-protein interaction, which has allowed the development of blocking compounds or peptides as preventing strategies; likewise, mechanisms of some pathogenic E. coli strains, which have developed sophisticated strategies to overcome the colonization barriers imposed by the microbiota; and finally, mechanisms to regulate the expression of factors related with the lifestyle of these bacterial pathogens as those forming bacterial communities or new mechanisms of remote interaction among bacteria and host cells, such as the delivery of vesicles containing cargo molecules.

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Acknowledgments

We thank Aylin Larrañaga and Marvin Paz for the drawings in Figs. 4.1 and 4.3.

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Authors and Affiliations

  1. Department of Cell Biology, Centro de Investigación y de Estudios Avanzados, Mexico City, Mexico

    Fernando Navarro-García

  2. Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada

    Antonio Serapio-Palacios

  3. Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

    Bertha González-Pedrajo

  4. Instituto de Agrobiotecnología y Biología Molecular INTA-CONICET, Hurlingham, Buenos Aires, Argentina

    Mariano Larzábal

  5. Centro Universitario de Estudios Microbiológicos y Parasitológicos, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina

    Nora Molina

  6. Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago, Chile

    Roberto Vidal

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  1. Fernando Navarro-García
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  2. Antonio Serapio-Palacios
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  3. Bertha González-Pedrajo
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  4. Mariano Larzábal
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  5. Nora Molina
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  6. Roberto Vidal
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Correspondence to Fernando Navarro-García .

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  1. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA

    Alfredo G. Torres

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© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Navarro-García, F., Serapio-Palacios, A., González-Pedrajo, B., Larzábal, M., Molina, N., Vidal, R. (2023). New Molecular Mechanisms of Virulence and Pathogenesis in E. coli. In: Torres, A.G. (eds) Trending Topics in Escherichia coli Research. Springer, Cham. https://doi.org/10.1007/978-3-031-29882-0_4

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