Abstract
Clinical examination is crucial during diagnostics of many diseases, including carotid artery disease. One of the most commonly used imaging techniques is the ultrasound (US) examination. However, the main drawback of US examination is that only two-dimensional (2D) cross-sectional images are obtained. For a more detailed analysis of the state of the patient’s carotid bifurcation it would be very useful to analyze a three-dimensional (3D) model. Within this study, an improved methodology for the 3D reconstruction is proposed. US images were segmented by using deep convolutional neural networks, and lumen and arterial wall regions are extracted. Instead of using a generic model of the carotid artery as the basis that is further adapted to the particular patient with individual US cross-sectional images, in the presented approach the longitudinal cross-sectional US image of the whole carotid bifurcation is used to extract the shape of the whole geometry, which ensures more realistic 3D model. Computer AI-based 3D reconstruction of patient-specific geometry could ensure more complete view of the carotid bifurcation, but also this geometry could be further used within numerical simulations such as blood flow simulation or simulation of plaque progression, that could provide additional quantitative information useful for clinical diagnostics and treatment planning.
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References
Sun, T., et al.: Comparative evaluation of support vector machines for computer aided diagnosis of lung cancer in CT based on a multi-dimensional data set. Comput. Method Programs Biomed. 111(2), 519–524 (2013)
Shi, J., Su, Q., Zhang, C., Huang, G., Zhu, Y.: An intelligent decision support algorithm for diagnosis of colorectal cancer through serum tumor markers. Comput. Method Programs Biomed. 100(2), 97–107 (2010)
Shen, D., Wu, G., Suk, H.I.: Deep learning in medical image analysis. Annu. Rev. Biomed. Eng. 19, 221–248 (2017)
Ravì, D., et al.: Deep learning for health informatics. IEEE J. Biomed. Health Inform. 21(1), 4–21 (2016)
Krizhevsky, A., Sutskever, I., Hinton, G.E.: Imagenet classification with deep convolutional networks. In: Advances in Neural Information Processing Systems, pp. 1097–1105 (2012)
Szegedy, C., et al.: Going deeper with convolution. In: IEEE Conference Computer Vision and Pattern Recognition (2015)
He, K., Zhang, X., Ren, S., Sun, J.: Delving deep into rectifiers: Surpassing human-level performance on imagenet classification. In: Computer Vision and Pattern Recognition (2015)
Milletari, F., et al.: Hough-CNN: Deep learning for segmentation of deep brain regions in MRI and ultrasound. Comput. Vis. Image Unrestanding 164, 92–102 (2017)
Sustersic, T., Anic, M., Filipovic, N.: Heart left ventricle segmentation in ultrasound images using deep learning. In: 20th IEEE Mediterranean Electrotechnical Conference, MELECON 2020 - Proceedings, pp. 321–324 (2020)
Arsic, B., Obrenovic, M., Anic, M., Tsuda, A., Filipovic, N.: Image segmentation of the pulmonary acinus imaged by synchrotron x-ray tomography. In: Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (2019)
Goodfelow, I.C.A., Bengio, Y.: Deep Learning. In: Goodfellow, Y., Bengio, Y., Aaron, C. (eds.) Google Books, MIT Press, Cambridge (2016)
Lanza, G., Giannandrea, D., Lanza, J., Ricci, S., Gensini, G.F.: Personalized-medicine on carotid endarterectomy and stenting. Ann. Transl. Med. 8(19), 1274 (2020)
Alzubaidi, L., et al.: Review of deep learning: concepts, CNN architectures, challenges, applications, future directions. J. Big Data 8(1), 1–74 (2021). https://doi.org/10.1186/s40537-021-00444-8
Djukic, T., Arsic, B., Koncar, I., Filipovic, N.: 3D Reconstruction of patient-specific carotid artery geometry using clinical ultrasound imaging. In: Miller, K., Wittek, A., Nash, M., Nielsen, P.M.F. (eds.) Computational Biomechanics for Medicine. pp. 73–83. Springer, Cham (2021). https://doi.org/10.1007/978-3-030-70123-9_6
Đukić, T., Arsić, B., Đorović, S., Končar, I., Filipović, N.: Validation of the machine learning approach for 3D reconstruction of carotid artery from ultrasound imaging. In: IEEE 20th International Conference on Bioinformatics and Bioengineering (BIBE) (2020)
Đukić, T., Saveljić, I., Pelosi, G., Parodi, O., Filipović, N.: Numerical simulation of stent deployment within patient-specific artery and its validation against clinical data. Comput. Methods Programs Biomed. 175, 121–127 (2019)
Đukić, T., Saveljić, I., Pelosi, G., Parodi, O., Filipović, N.: A study on the accuracy and efficiency of the improved numerical model for stent implantation using clinical data. Comput. Methods Programs Biomed. 207, 106196 (2021)
Milošević, M., Anić, M., Nikolić, D., Milićević, B., Kojić, M., Filipović, N.: InSilc computational tool for in silico optimization of drug-eluting bioresorbable vascular scaffolds. Comput. Math. Methods Med. 2022, 5311208 (2022)
Đukić, T., Filipović, N.: Simulating fluid flow within coronary arteries using parallelized sparse lattice Boltzmann method. In: 8th International Congress of Serbian Society of Mechanics, Kragujevac, Serbia (2021)
Đukić, T., Topalović, M., Filipović, N.: Validation of lattice boltzmann based software for blood flow simulations in complex patient-specific arteries against traditional CFD methods. Math. Comput. Simul. 203, 957–976 (2022)
Filipović, N., Teng, Z., Radović, M., Saveljić, I., Fotiadis, D., Parodi, O.: Computer simulation of three-dimensional plaque formation and progression in the carotid artery. Med. Biol. Eng. Comput. 51, 607–616 (2013)
Filipović, N., et al.: Three-dimensional numerical simulation of plaque formation and development in the arteries. IEEE Trans. Inf. Technol. Biomed. 16(2), 272–278 (2012)
Parodi, O., et al.: Patient-specific prediction of coronary plaque growth from CTA angiography: a multiscale model for plaque formation and progression. IEEE Trans. Inf. Technol. Biomed. 16(5), 952–956 (2012)
Đukić, T., Filipović, N.: Simulation of carotid artery plaque development and treatment. In: Cardiovascular and Respiratory Bioengineering, Elsevier, pp. 101–133 (2022)
Ravindraiah, R., Tejaswini, K.: A survey of image segmentation algorithms based on fuzzy clustering. Int. J. Comput. Sci. Mob. Comput. 2(7), 200–206 (2013)
Long, J., Shelhamer, E., Darrell, T.: Fully convolutional networks for semantic segmentation. In: Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition (2015)
Sinonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. In: 3rd International Conference on Learning Representations, ICLR 2015 - Conference Track Proceedings (2015)
Badrinarayanan, V., Kendall, A., Cipolla, R.: SegNet: a deep convolutional encoder-decoder architecture for image segmentation. IEEE Trans. Pattern Anal. Mach. Intell. 39(12), 2481–2495 (2017)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Zhou, X.Y., Yang, G.Z.: Normalization in training U-Net for 2-D biomedical semantic segmentation. IEEE Robot. Autom. Lett. 4(2), 1792–1799 (2019)
Perktold, K., Peter, R.O., Resch, M., Langs, G.: Pulsatile non-newtonian blood flow in three-dimensional carotid bifurcation models: a numerical study of flow phenomena under different bifurcation angles. J. Biomed. Eng. 13(6), 507–515 (1991)
Perktold, K., Resch, M., Peter, R.O.: Three-dimensional numerical analysis of pul-satile flow and wall shear stress in the carotid artery bifurcation. J. Biomech. 24, 409–420 (1991)
Vukicevic, A.M., Stepanovic, N.M., Jovicic, G.R., Apostolovic, S.R., Filipovic, N.D.: Computer methods for follow-up study of hemodynamic and disease progression in the stented coronary artery by fusing IVUS and X-ray angiography. Med. Biol. Eng. Comput. 52(6), 539–556 (2014). https://doi.org/10.1007/s11517-014-1155-9
Vukicevic, A., Çimen, S., Jagic, N., Jovicic, G., Frangi, A.F., Filipovic, N.: Three-dimensional reconstruction and NURBS-based structured meshing of coronary arteries from the conventional X-ray angi-ography projection images. Sci. Rep. 8, 1711 (2018)
Antiga, L., Steinman, D.: Robust and objective decomposition and mapping of bifurcating vessels. IEEE Trans. Med. Imaging 23(6), 704–713 (2004)
Zhang, Y., Bazilevs, Y., Goswami, S., Bajaj, C., Hughes, T.: Patient-specific vascular NURBS modeling for isogeometric analysis of blood flow. Comput. Methods. Appl. Mech. Eng. 196(29–30), 2943–2959 (2007)
Filipovic, N., Mijailovic, S., Tsuda, A., Kojic, M.: An implicit algorithm within the arbitrary Lagrangian-Eulerian formulation for solving incompressible fluid flow with large boundary motions. Comp. Meth. Appl. Mech. Engrg. 195, 6347–6361 (2006)
Kojić, M., Filipović, N., Stojanović, B., Kojić, N.: Computer modeling in bioengineering: Theoretical Background, Examples and Software. Wiley, Chichester (2008)
Long, Q., Xu, X., Köhler, U., Robertson, M.B., Marshall, I., Hoskins, P.: Quantitative comparison of CFD predicted and MRI measured velocity fields in a carotid bifurcation phantom. Biorheology 39, 467–474 (2002)
Cibis, M., Potters, W., Selwaness, M., Gijsen, F., Franco, O., Arias Lorza, A.E.A.: Relation between wall shear stress and carotid artery wall thickening MRI versus CFD. J Biomech. 49(5), 735–741 (2016)
Gharahi, H., Zambrano, B.Z.D., DeMarco, K., Seungik, B.: Computational fluid dynamic simulation of human carotid artery bifurcation based on anatomy and volumetric blood flow rate measured with magnetic resonance imaging. Int. J. Adv. Eng. Sci. Appl. Math. (2016). https://doi.org/10.1007/s12572-016-0161-6
Rispoli, V., Nielsen, J., Nayak, K., Carvalho, J.: Computational fluid dynamics simulations of blood flow regularized by 3D phase contrast MRI. Biomed. Eng. (2015). https://doi.org/10.1186/s12938-015-0104-7
Lopes, D., Puga, H., Teixeira, J., Teixeira, S.: Influence of arterial mechanical properties on carotid blood flow: comparison of CFD and FSI studies. Int. J. Mech. Sci. 160, 209–218 (2019)
Markl, M., et al.: In vivo wall shear stress distribution in the carotid artery: effect of bifurcation geometry, internal carotid artery stenosis, and recanalization therapy. Circ. Cardiovasc. Imaging 647–55 (2010) https://doi.org/10.1161/CIRCIMAGING.110.958504
Acknowledgments
The research presented in this study was part of the project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 755320–2 - TAXINOMISIS. This article reflects only the author’s view. The Commission is not responsible for any use that may be made of the information it contains.
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Anić, M., Đukić, T. (2023). Improved Three-Dimensional Reconstruction of Patient-Specific Carotid Bifurcation Using Deep Learning Based Segmentation of Ultrasound Images. In: Filipovic, N. (eds) Applied Artificial Intelligence: Medicine, Biology, Chemistry, Financial, Games, Engineering. AAI 2022. Lecture Notes in Networks and Systems, vol 659. Springer, Cham. https://doi.org/10.1007/978-3-031-29717-5_15
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