Abstract
The clinical and personal importance of allotransplantation clearly shows it is one of the great triumphs of medicine; its tragedy, as this chapter demonstrates, is that demand outstrips supply and the COVID-19 pandemic has made the global shortfall far worse. Living and deceased donations are both important. The main ways of increasing living donation are relaxing criteria for donation, offering incentives, either financial or medical, and increasing the range of potential recipients, especially through social media. Deceased donations either following circulatory death or brain death, require consent from relatives in most cases, even if the wishes of the deceased have been clearly expressed. The pros and cons of opt-out systems are discussed, along with the idea of abolishing the ‘dead donor rule’ to obtain more organs. Transplant systems operate fundamentally on public trust and if this is lost, donations decrease. As demand for organs looks set to increase, alternatives to allotransplantation will be increasingly needed.
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Notes
- 1.
Except in the rare circumstances of ‘domino donations’.
- 2.
Previously referred to as donation after cardiac death or ‘non-heart-beating’ donors.
- 3.
Previously referred to as ‘beating-heart’ donors.
References
World Health Organization, Global Observatory on Donation and Transplant, 2019. Data. http://www.transplant-observatory.org/wp-content/uploads/2021/06/GODT2019-data_web_updated-June-2021.pdf
Byrnes IS, Stenzel A. The power of two: a twin triumph over cystic fibrosis. Missouri: University of Missouri Press; 2007.
Anonymous. Plot summary of The Power of Two movie The Power of Two (2011) - Plot Summary-IMDb.
de Kerangal M. Mend the living. London: Maclehose Press; 2016.
Stammers T. Organ trafficking: why do healthcare workers engage in it? Camb Q Healthc Ethics. 2022;31(3):368–78.
Global observatory on donation and transplant, Statistics for 2020. http://www.transplant-observatory.org/
Aubert O, Yoo D, Zielinski D, et al. COVID-19 pandemic and worldwide organ transplantation: a population-based study. Lancet Public Health. 2021;6(10):e709–19.
Segev DL, Muzaale AD, Caffo BS, Mehta SH, Singer AL, Taranto SE, Montgomery RA. Perioperative mortality and long-term survival following live kidney donation. JAMA. 2010;303(10):959–66.
Muzaale AD, Massie AB, Wang M-C, Montgomery RA, McBride MA, Wainright JL, Segev DL. Risk of end-stage renal disease following live kidney donation. JAMA. 2014;311(6):579–86.
Muzaale AD, Dagher NN, Montgomery RA, et al. Estimates of early death, acute liver failure, and long-term mortality among live liver donors. Gastroenterology. 2012;142:273–80.
Kiberd BA, Tennankore KK. Lifetime risks of kidney donation: a medical decision analysis. BMJ Open. 2017;7:e016490.
Thomas E. Starzl, ethical problems in organ transplantation. Ann Intern Med. 1967;67(3):32–6.
Health Resources and Services Administration. 2019. Data. https://data.hrsa.gov/topics/health-systems/organ-donation
US Organ Procurement and Transplantation Network Organ donation again sets record in 2019. https://optn.transplant.hrsa.gov/news/organ-donation-again-sets-record-in-2019/
NHS Organ and Tissue Donation and Transplantation Activity Report 2020–21. Fig 2.2, p 5. https://nhsbtdbe.blob.core.windows.net/umbraco-assets-corp/23461/activity-report-2020-2021.pdf
World Health Organization. Global Observatory on Donation and Transplantation 2021. http://www.transplant-observatory.org/wp-content/uploads/2021/06/GODT2019-data_web_updated-June-2021.pdf. Slide 2.
United Network for Organ Sharing (UNOS) COVID-19 and solid organ transplant. https://unos.org/covid/
Lentine KL, et al. Survey of US living kidney donation and transplantation practices in the COVID-19 Era. Kidney Int Rep. 2020;5:1894–905.
Merrill JP, Murray JE, Harrison JH, Guild WR. Successful homotransplantations of human kidneys between identical twins. JAMA. 1956;160:277–82.
Stammers T. The evolution of autonomy. The New Bioethics. 2015;21(2):155–63.
Mandelbrot DA, Pavlakis M, Danovitch GM, et al. The medical evaluation of living kidney donors: a survey of US transplant centers. Am J Transplant. 2007;7(10):2333–43.
Canadian Blood Services. Can I be a donor if I am older? https://www.blood.ca/en/organs-tissues/deceased-donation/am-i-eligible
Rakké YS, Zuidema WC, Hilhorst MT, et al. Seriously ill patients as living unspecified kidney donors: rationale and justification. Transplantation. 2015;99:232–5.
Sickand M, Cuerden MS, Klarenbach SW, Ojo AO, Parikh CR, Boudville N, Garg AX. Donor nephrectomy outcomes research network. Reimbursing live organ donors for incurred non-medical expenses: a global perspective on policies and programs. Am J Transplant. 2009;12:2825–36.
National Kidney Federation, Reimbursement of living donor expenses. https://www.kidney.org.uk/reimbursement-of-living-donor-exp
NHS England 2018. Commissioning policy: reimbursement of expenses for living donors. https://www.england.nhs.uk/wp-content/uploads/2018/08/Policy-Reimbursement-of-Expenses-for-Living-Donors-Updated-August-2018.pdf
Manatu Hauora (Ministry of Health), New Zealand, Compensation for Live Organ Donors. https://www.health.govt.nz/our-work/hospitals-and-specialist-care/organ-donation-and-transplantation/compensation-live-organ-donors#:~:text=About%20the%20Compensation%20for%20Live%20Donors%20Act&text=The%20Act%3A,of%20up%20to%2012%20weeks
Kidney Foundation, Living Donor Expense Reimbursement Program. https://kidney.ca/Support/Programs-Services/living-organ-donor-reimbursement-program#:~:text=The%20Living%20Organ%20Donor%20Expense,far%20away%20from%20the%20recipient
Siddique AB, Apte V, Fry-Revere S, Jin Y, Koizumi N. The impact of country reimbursement programmes on living kidney donations. BMJ Glob Health. 2020;5(8):e002596.
Chatterjee P, Venkataramani AS, Vijayan A, et al. The effect of state policies on organ donation and transplantation in the United States. JAMA Intern Med. 2015;175:1323.
Ghods AJ. Organ transplantation in Iran. Saudi J Kidney Dis Transpl. 2007;18:648–55.
Al Sebayel M, Alenazi AM, Sabbagh R, et al. Donor organ shortage crisis: a case study review of a financial incentive-based system. Transplant Proc. 2014;46(6):2030–5.
Fisher JS, Butt Z, Friedewald J, et al. Between scylla and charybdis: charting an ethical course for research into financial incentives for living kidney donation. Am J Transplant. 2015;15(5):1180–6.
Ashkenazi T, Lavee L, Mor E. Organ donation in Israel-achievements and challenges. Transplantation. 2015;99:265–6.
Iyer TK. Kidneys for transplant–“opting out” law in Singapore. Forensic Sci Int. 1987;35:131–40.
Kluge E-HW. Designated organ donation: private choice in social context. Hast Cent Rep. 1989;19:10–6.
Matching Donors. https://matchingdonors.com/life/. Accessed 31 Oct 2022. There were 15645 potential donors listed.
Human Tissue Authority. https://www.hta.gov.uk/guidance-public/living-organ-donation/living-organ-donation-matching-websites-and-social-media
Cameron AM, Massie AB, Alexander CE, et al. Social media and organ donor registration: the Facebook effect. Am J Transplant. 2013;13:2059–65.
Ruck JM, Henderson ML, Eno AK, et al. Use of twitter in communicating living solid organ donation information to the public: an exploratory study of living donors and transplant professionals. Clin Transpl. 2019;33(1):e13447.
Moorlock G, Draper H. Empathy, social media, and directed altruistic living organ donation. Bioethics. 2018;32:289–97.
NHS Blood and Transplant 2021. Organ and Tissue Donation and Transplantation Activity Report 2020/21. https://nhsbtdbe.blob.core.windows.net/umbraco-assets-corp/23461/activity-report-2020-2021.pdf. Accessed 9 Sept 2021. There were 1580 deceased donors and 1058 living donors in 2019.
Association of Organ Procurement Organizations New Data Shows 2020 is Record Year for Organ Donation and Transplant. https://aopo.org/2020-record-year-for-organ-donation-and-transplant/#:~:text=More%20than%2012%2C500%20people%20donated,%2Dover%2Dyear%20growth%20rate
Global Observatory on Donation and Transplantation. http://www.transplant-observatory.org/countkidney/
Terunuma Y, Mathis BJ. Cultural sensitivity in brain death determination: a necessity in end-of-life decisions in Japan. BMC Med Ethics. 2021;22(1):58.
Kwek TK, Lew TWK, et al. The transplantable organ shortage in Singapore–has implementation of presumed consent to organ donation made a difference? Ann Acad Med Singap. 2009;38:346–53.
Harris J. Consent and end of life decisions. J Med Ethics. 2003;29:10–5.
Vincent A, Logan L. Consent for organ donation. Br J Anaesth. 2012;108(Suppl. 1):i80–7.
Organ Donation Task Force Working Together to Save Lives 2011. https://bts.org.uk/wp-content/uploads/2016/09/The-Organ-Donation-Taskforce-Implementation-Programmes-Final-Report-2011.pdf
In 2019 Spain had a donor rate of 49.6 donors per million, the highest in Europe. https://www.lamoncloa.gob.es/lang/en/gobierno/news/Paginas/2020/20200907organ-donation.aspx
NHS Blood and Transplant. What is the opt out system in England? https://www.organdonation.nhs.uk/helping-you-to-decide/about-organ-donation/faq/what-is-the-opt-out-system/
Shaw D. We should not let families stop organ donation from their dead relatives. Br Med J. 2012;345:33.
Robertson J. Relaxing the death standard for organ donation in pediatric situations. In: Mathieu D, editor. Organ substitution technology: ethical, legal, and public policy issues. Boulder: Westview Press; 1988. p. 69.
Boucek MM, Mashburn C, Dunn SM, et al. Pediatric heart transplantation after declaration of cardiocirculatory death. N Engl J Med. 2008;359(7):709–14.
Lazaridis C, Blumenthal-Barby JS. Organ donation beyond brain death: donors as ends and maximal utility. Am J Bioeth. 2015;15(8):17–9.
Rodríguez-Arias D, Smith MJ, Lazar NM. Donation after circulatory death: burying the dead donor rule. Am J Bioeth. 2011;11(8):36–43.
Smith AP. Abandoning the dead donor rule. [published online ahead of print, 2022 Oct 3]. J Med Ethics. 2022; medethics-2021-108049.
Woien S. Donation after cardiac death: an alternative solution to burying the dead donor rule. Am J Bioeth. 2011;11(8):54–6.
Stammers T. The ethics of global organ acquisition Chapter 3. Bloomsbury; 2023
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Stammers, T. (2023). Allotransplantation Ethics. In: Hurst, D.J., Padilla, L., Paris, W.D. (eds) Xenotransplantation. Springer, Cham. https://doi.org/10.1007/978-3-031-29071-8_2
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