Abstract
This chapter describes approaches to explaining the patterns of health described in Chap. 1. It opens by reviewing the concepts of understanding and explanation; it outlines the roles of theory, concepts, and conceptual models in explaining empirical findings. It then reviews varying conceptions of causality and discusses the role of chance in generating patterns of health; it clarifies the connection between risk factors and determinants of health. It describes the application of systems thinking in social epidemiology and reviews some traditional explanatory epidemiologic models – the epidemiologic triad, causal webs, INUS and Rothman’s ‘pies’ model. It discusses the limitations of these in understanding the mechanisms that generate social inequities in health. It then turns to review additional approaches to explanation, including complexity thinking and emergent phenomena, Chaos Theory, and Catastrophe Theory. It finishes by outlining ways to model dynamically interacting causal influences.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
- 1.
To avoid potential confusion: mythos, here, does not refer to a popular brand of Greek beer.
- 2.
Felix qui potuit rerum cognoscere causas (Virgil: Georgics, ii, 490).
- 3.
Echoes, here, of the PICO framework for formulating clinical questions in evidence-based medicine.
- 4.
A graph is ‘directed’ if all the arcs between variables are directional arrows; it is acyclic (or recursive) if there are no closed loops in the diagram. Recursive means that the causal influence acts only in one direction: variables affect only their descendants. (S. Greenland et al. Epidemiology 1999; 10: 39).
- 5.
John Last attributed this to T.R. Dawber et al., Am J Public Health 1959; 49: 1349–56, but it is frequently ascribed to the subsequent textbook by B. MacMahon and T.F. Pugh, Epidemiology: Principles and Methods, Little Brown, Boston, 1970.
References
Rosenstock IM. The health belief model and preventive health behavior. Health Educ Monogr. 1974;2:354–86.
Kunitz SJ. Explanations and ideologies of mortality patterns. Popul Dev Rev. 1987;13(3):379–408.
Ferguson N. The war of the world. London: Penguin Books; 2006.
Wilson EO. Consilience: the unity of knowledge. New York: Alfred A. Knopf; 1998.
Higginbotham N, Albrecht GL, Connor L. Health social science: a transdisciplinary and complexity perspective. Melbourne: Oxford University Press; 2001.
Deaton A. Policy implications of the gradient of health and wealth. Health Aff. 2002;21(2):13–30.
Berry WD. Nonrecursive causal models. Sage University paper series on quantitative applications in the social sciences. Newbury Park: Sage; 1984. p. 07–037.
Walsh WH. Philosophy of history: an introduction. New York: Harper & Row, Harper Torchbooks; 1960.
Hawking S, Mlodinow L. The grand design. New York: Bantam Books; 2010.
Holland PW. Statistics and causal inference. J Am Stat Assoc. 1986;81(396):945–70.
Lipton P. Contrastive explanation. In: Knowles D, editor. Explanation and it limits. Cambridge: Cambridge University Press; 1990. p. 246–66.
Carnap R. The value of laws: explanation and prediction. In: Curd M, Cover JA, editors. Philosophy of science: the central issues. New York: WW Norton & Company; 1998. p. 678–84.
Krieger N. Epidemiology and the web of causation: has anyone seen the spider? Soc Sci Med. 1994;39(7):887–903.
Hill J. Reasons and causes: the nature of explanations in psychology and psychiatry. Psychol Med. 1982;12:501–14.
Bhopal RS. Cause and effect: the epidemiological approach. Chapter 5 in: Bhopal RS. Concepts of epidemiology: an integrated introduction to the ideas, theories, principles and methods of epidemiology. Oxford: Oxford University Press; 2016. p. 131–182.
Pearl J. Causality: models, reasoning, and inference. 2nd ed. New York: Cambridge University Press; 2009.
Susser M, Susser E. Choosing a future for epidemiology: II. From black box to Chinese boxes and eco-epidemiology. Am J Public Health. 1996;86(5):674–7.
Weed DL. Beyond black box epidemiology. Am J Public Health. 1998;88:12–4.
Koopman JS. Comment: emerging objectives and methods in epidemiology. Am J Public Health. 1996;86(5):630–2.
Weed DL. Theory and practice in epidemiology. Ann N Y Acad Sci. 2001;954:52–62.
Chafetz J. A primer on the construction of theories in sociology. Itasca: Peacock; 1978.
Popper K. The logic of scientific discovery. London: Routledge; 1959.
Bailey KD. Alternative procedures for macrosociological theorizing. Qual Quant. 1991;25:37–55.
Vineis P. Proof in observational medicine. J Epidemiol Community Health. 1997;51(1):9–13.
Carpiano RM, Daley DM. A guide and glossary on postpositivist theory building for population health. J Epidemiol Community Health. 2005;60(7):564–70.
Krieger N. Theories for social epidemiology in the 21st century: an ecosocial perspective. Int J Epidemiol. 2001;30(4):668–77.
Kuhn T. The structure of scientific revolutions. Chicago: University of Chicago Press; 1962.
Hempel CG. Aspects of scientific explanation and other essays in the philosophy of science. New York: Free Press; 1965.
Buck C. Popper’s philosophy for epidemiologists. Int J Epidemiol. 1976;5(1):97–8.
Flack J. Coarse-graining. In: Brockman J, editor. This idea is brilliant: lost, overlooked, and underappreciated scientific concepts everyone should know. New York: Harper Perennial; 2018.
Pearce N. Traditional epidemiology, modern epidemiology, and public health. Am J Public Health. 1996;86(5):678–83.
Blalock HM. Contextual-effects models: theoretical and methodological issues. Annu Rev Sociol. 1984;10:353–72.
Avendano M, Kawachi I. Why do Americans have shorter life expectancy and worse health than do people in other high-income countries? Annu Rev Public Health. 2014;35:307–25.
Glimcher PW, Rustichini A. Neuroeconomics: the consilience of brain and decision. Science. 2004;306(5695):447–52.
Ross L. The intuitive psychologist and his shortcomings: distortions in the attribution process. In: Berkowitz L, editor. Advances in experimental and social psychology. 10. New York: Academic; 1977. p. 174–220.
Archer MS. Realist social theory: the morphogenetic approach. Cambridge: Cambridge University Press; 1995.
Krull DS. On partitioning the fundamental attribution error: dispositionalism and the correspondence bias. In: Moskowitz GB, editor. Cognitive social psychology: the Princeton symposium on the legacy and future of social cognition. Mahwah: Lawrence Erlbaum Associates Inc; 2013. p. 211–27.
Choi I, Nisbett RE, Norenzayan A. Causal attribution across cultures: variation and universality. Psychol Bull. 1999;125(1):47–63.
Meling D. Knowing groundlessness: an enactive approach to a shift from cognition to non-dual awareness. Front Psychol. 2021;12(697821):1–12.
Susser M. The logic in ecological: I. the logic of analysis. Am J Public Health. 1994;84(5):825–9.
Dawkins R. The blind watchmaker. London: Penguin Books; 1986.
Tennen H, Affleck G, Armeli S, Carney MA. A daily process approach to coping. Am Psychol. 2000;55(6):626–36.
McDowell I, Maclean L. Blending qualitative and quantitative study methods in health services research. Health Informatics J. 1998;4:15–22.
Rose G. Sick individuals and sick populations. Int J Epidemiol. 1985;14(1):32–8.
Capra F. The web of life: a new scientific understanding of living systems. New York: Anchor Books; 1996.
Holt-Lunstad J. Why social relationships are important for physical health: a systems approach to understanding and modifying risk and protection. Annu Rev Psychol. 2018;69:437–58.
Reis HT, Collins WA, Berscheid E. Relationship context of human behavior and development. Psychol Bull. 2000;126(6):844–72.
Capra F. The turning point. New York: Simon & Schuster; 1982.
Maturana HR, Varela FJ. Autopoiesis and cognition: the realization of the living. Dordrecht: D. Reidel Publishing Co; 1980.
Di Paolo E. Enactive becoming. Phenomenol Cogn Sci. 2020;19(1):1–27.
Di Paolo E. Autopoiesis, adaptivity, teleology, agency. Phenomenol Cogn Sci. 2005;4:429–52.
Dossey L. Space, time and medicine. Boston: New Science Library; 1985.
Nicolis G, Prigogine I. Self-organization in non-equilibrium systems. New York: Wiley; 1977.
Simonton OC, Matthews-Simonton S, Creighton J. Getting well again. Los Angeles: J.P. Tarcher, Inc; 1978.
Diez Roux AV. Conceptual approaches to the study of health disparities. Annu Rev Public Health. 2011;33:41–58.
Novick LR, Cheng PW. Assessing interactive causal influence. Psychol Rev. 2004;111(2):455–85.
Haddon W. Energy damage and the ten countermeasure strategies. J Trauma. 1973;13(4):321–31.
Casti JL. Complexification: explaining a paradoxical world through the science of surprise. New York: Harper Perennial; 1994.
Hume D. An enquiry concerning human understanding; 1748. Available from https://socialsciences.mcmaster.ca/~econ/ugcm/3ll3/hume/enquiry.pdf.
Capra F. The Tao of physics. Boulder: Shambala Publications; 1975.
Spiegelhalter DJ. Understanding uncertainty. Ann Fam Med. 2008;6(3):196–7.
Maruyama Y. Category theory and foundations of life science: a structuralist perspective on cognition. Biosystems. 2021;203:104376.
Bradley L. Chaos & fractals; 2010 [Accessed January, 2022]. Available from https://www.stsci.edu/~lbradley/seminar/laplace.html.
Elbow P. The uses of binary thinking. J Adv Compos. 1993;14:22–51.
Zadeh L. Fuzzy sets. Inf Control. 1965;8:338–53.
Pirsig RM. Zen and the art of motorcycle maintenance. 2nd. ed. New York: William Morrow and Company; 1974. p. 1999.
Stinchcombe AL. Constructing social theories. New York: Harcourt, Bruce & World, Inc.; 1968.
Susser M. What is a cause and how do we know one? A grammar for pragmatic epidemiology. Am J Epidemiol. 1991;133(7):635–48.
Vandenbroucke JP, Broadbent A, Pearce N. Causality and causal inference in epidemiology: the need for a pluralistic approach. Int J Epidemiol. 2016;45(6):1776–86.
Rothman KJ. Modern epidemiology. Boston: Little, Brown; 1986.
Renton A. Epidemiology and causation: a realist view. J Epidemiol Community Health. 1994;48:79–85.
Maldonado G, Greenland S. Estimating causal effects. Int J Epidemiol. 2002;31:422–9.
Varela M, Ruiz-Esteban R, Mestre De Juan MJ. Chaos, fractals, and our concept of disease. Perspect Biol Med. 2010;53(4):584–95.
Mackie JL. Causes and conditions. Am Philos Q. 1965;2(4):245–55.
Mackie J. The cement of the universe. Oxford: Oxford University Press; 1974.
Blalock HM. Causal inferences in nonexperimental research. Chapel Hill: The University of North Carolina Press; 1961.
Blalock HM. Causal models in the social sciences. Chicago: Aldine Atherton Inc; 1971.
Glymour MM, Rudolph KE. Causal inference challenges in social epidemiology: bias, specificity, and imagination. Soc Sci Med. 2016;166:258–65.
Galea S, Link BG. Six paths for the future of social epidemiology. Am J Epidemiol. 2013;178(6):843–9.
Hernán MA. The C-word: scientific euphemisms do not improve causal inference from observational data. Am J Public Health. 2018;108(5):616–9.
Jones HE, Schooling CM. Let’s require the “T-word”. Am J Public Health. 2018;108(5):624.
Tinbergen N. On the aims and methods of ethology. Z Tierpsychol. 1963;20:410–33.
Millard AV. A causal model of high rates of child mortality. Soc Sci Med. 1994;38:253–68.
Schaffner KF. Discovery and explanation in biology and medicine. Chicago University of Chicago Press; 1993.
Rose G. The strategy of preventive medicine. Oxford: Oxford University Press; 1992.
Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51(6):1173–82.
Link BG, Phelan J. Social conditions as fundamental causes of disease. J Health Soc Behav. 1995;36(Suppl):80–94.
Phelan JC, Link BG. Is racism a fundamental cause of inequalities in health? Annu Rev Sociol. 2015;41:311–30.
Phelan JC, Link BG, Diez Roux AV, Kawachi I, Levin B. “Fundamental causes” of social inequalities in mortality: a test of the theory. J Health Soc Behav. 2004;45:265–85.
Mackenbach JP. Persistence of social inequalities in modern welfare states: explanation of a paradox. Scand J Public Health. 2017;45:113–20.
Zajacova A, Lawrence EM. The relationship between education and health: reducing disparities through a contextual approach. Annu Rev Public Health. 2018;39:273–89.
Berkman LF. Introduction: seeing the forest and the trees – from observation to experiments in social epidemiology. Epidemiol Rev. 2004;26:2–6.
Broadbent A. Causation and prediction in epidemiology: a guide to the “methodological revolution”. Stud Hist Phil Biol Biomed Sci. 2015;54(1):72–80.
Glass TA, Goodman SN, Hernan MA, Samet JM. Causal inference in public health. Annu Rev Public Health. 2013;34:61–75.
Parascandola M, Weed DL. Causation in epidemiology. J Epidemiol Community Health. 2001;55(12):905–12.
Maldonado G. The role of counterfactual theory in causal reasoning. Ann Epidemiol. 2016;26:681–2.
Schwartz S, Gatto NM, Campbell UB. Causal identification: a charge of epidemiology in danger of marginalization. Ann Epidemiol. 2016;26(10):669–73.
Hernán MA, Taubman SL. Does obesity shorten life? The importance of well-defined interventions to answer causal questions. Int J Obes. 2008;32:S8–S14.
Kaufman JS. Commentary: causal inference for social exposures. Annu Rev Public Health. 2019;40:7–21.
Hernán MA. A definition of causal effect for epidemiological research. J Epidemiol Community Health. 2004;58(4):265–71.
VanderWeele TJ. Invited commentary: counterfactuals in social epidemiology – thinking outside of “the box”. Am J Epidemiol. 2019;189(3):175–8.
Hernán MA. Does water kill? A call for less causal inferences. Ann Epidemiol. 2016;26:674–80.
McMichael AJ. Prisoners of the proximate: loosening the constraints on epidemiology in an age of change. Am J Epidemiol. 1999;149(10):887–97.
Pearl J. Causal diagrams for empirical research. Biometrika. 1995;82:669–710.
Austin A, Desrosiers TA, Shanahan ME. Directed acyclic graphs: an under-utilized tool for child maltreatment research. Child Abuse Negl. 2019;91:78–87.
Greenland S, Pearl J, Robins JM. Causal diagrams for epidemiologic research. Epidemiology. 1999;10(1):37–48.
Murray CJL, Ezzati M, Lopez AD, Rodgers A, Vander HS. Comparative quantification of health risks: conceptual framework and methodological issues. In: Ezzati M, Lopez AD, Rodgers A, Murray CJL, editors. Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors. Geneva: World Health Organization; 2004.
White PA. The causal asymmetry. Psychol Rev. 2006;113(1):132–47.
Graham H. Social determinants and their unequal distribution: clarifying policy understandings. Milbank Q. 2004;82(1):101–24.
Krieger N. A glossary for social epidemiology. J Epidemiol Community Health. 2001;55(10):693–700.
Kraemer HC, Kazdin AE, Offord DR, Kessler RC, Jensen PS, Kupfer DJ. Coming to terms with the terms of risk. Arch Gen Psychiatry. 1997;54:337–43.
Miettinen OS. Theoretical epidemiology: principles of occurrence research in medicine. New York: Wiley; 1985.
Marchal C. Determinism, random, chaos, freedom. Henri Poincaré and the revolution of scientific ideas in the twentieth century. Regul Chaotic Dyn. 2005;10(3):227–37.
Carr NG. Mysterianism. In: Brockman J, editor. This idea is brilliant: lost, overlooked, and underappreciated scientific concepts everyone should know. New York: Harper Perennial; 2018. p. 211–3.
Asher M. A classification scheme for types of randomness; 2016. [Accessed April, 2018]. Available from http://www.statisticsblog.com/2012/02/a-classification-scheme-for-types-of-randomness/.
Lisi AG. Emergence. In: Brockman J, editor. This idea is brilliant: lost, overlooked and underappreciated scientific concepts everyone should know. New York: Harper Perennial; 2018. p. 21–3.
Cho A. Physicists say it’s simple. If the poor will always be with us, an analogy to the second law of thermodynamics may explain why. Science. 2014;344(6186):828.
Ulanowicz RE. On the nature of ecodynamics. Ecol Complex. 2004;1(4):341–54.
Popper K. Conjectures and refutations: the growth of scientific knowledge. London: Routledge and Kegan Paul; 1972.
Koivu-Jolma M, Annila A. Epidemic as a natural process. Math Biosci. 2018;299:97–102.
Vineis P. Epidemiology between social and natural sciences. J Epidemiol Community Health. 1998;52:616–7.
Greaves M. Cancer causation: the Darwinian downside of past success? Lancet Oncol. 2002;3:244–51.
Tomasetti C, Vogelstein B. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015;347(6217):78–81.
Syme SL. Individual vs. community interventions in public health practice: some thoughts about a new approach. Health Promot Matter. 1997;2:2–9.
Greaves D. Mystery in western medicine. Aldershot: Avebury; 1996. p. 168.
Taleb NN. The black swan: the impact of the highly improbable. London: Penguin Books; 2007.
Galea S, Hernán MA. Win-win: reconciling social epidemiology and causal inference. Am J Epidemiol. 2019;189(3):167–70.
Dahlgren G, Whitehead M. Policies and strategies to promote social equity in health. Background document to WHO – strategy paper for Europe; 1991. [Accessed July, 2021]. Available from https://core.ac.uk/download/pdf/6472456.pdf.
Barton H, Grant M. A health map for the local human habitat. J R Soc Promot Heal. 2006;126(6):252–3.
Graham H, White PCL. Social determinants and lifestyles: integrating environmental and public health perspectives. Public Health. 2016;141:270–8.
Mackie JL. Causes and conditions. In: Sosa E, Tooley M, editors. Causation. New York: Oxford University Press; 1993. p. 33–55.
Rothman KJ. Causes. Am J Epidemiol. 1976;104(6):587–92. https://doi.org/10.1093/oxfordjournals.aje.a112335.
Rothman KJ, Greenland S. Causation and causal inference in epidemiology. Am J Public Health. 2005;95(S1):S144–50.
Eisenberg JNS, Trostle J, Sorensen RJD, Shields KS. Toward a systems approach to enteric pathogen transmission: from individual independence to community interdependence. Annu Rev Public Health. 2012;33:239–57.
Philippe P, Mansi O. Nonlinearity in the epidemiology of complex health and disease processes. Theor Med Bioeth. 1998;19:591–607.
Hertzman C, Boyce T. How experience gets under the skin to create gradients in developmental health. Annu Rev Public Health. 2010;31:329–47.
Vallacher RR, Read SJ, Nowak A. The dynamical perspective in personality and social psychology. Personal Soc Psychol Rev. 2002;6(4):264–73.
Galea S, Riddle M, Kaplan GA. Causal thinking and complex system approaches in epidemiology. Int J Epidemiol. 2010;39(1):97–106.
Diez-Roux AV. Integrating social and biologic factors in health research: a systems view. Ann Epidemiol. 2007;17:569–74.
Gleick J. The information: a history, a theory, a flood. New York: Pantheon Books; 2011.
Sumpter DJT. The principles of collective animal behaviour. Philos Trans R Soc Lond Ser B Biol Sci. 2006;361(1465):5–22.
Macy MW, Willer R. From factors to actors: computational sociology and agent-based modeling. Annu Rev Sociol. 2002;28:143–66.
Tracy M, Cerda M, Keyes KM. Agent-based modeling in public health: current applications and future directions. Annu Rev Public Health. 2018;39:77–94.
Hernán MA. Invited commentary: agent-based models for causal inference – reweighting data and theory in epidemiology. Am J Epidemiol. 2019;181(2):103–5.
Marshall BDL, Galea S. Formalizing the role of agent-based modeling in causal inference and epidemiology. Am J Epidemiol. 2015;181(2):92–9.
Kernick D. Complexity and healthcare organization: a view from the street. Oxford: Radcliffe Medical Press Ltd.; 2004.
Weil A. What is integrative medicine? 2018. [Accessed January, 2019]. Available from https://www.drweil.com/health-wellness/balanced-living/meet-dr-weil/what-is-integrative-medicine/.
Wright J. Very brief advice can be effective in encouraging smokers to quit. London: Guidelines.Co.UK; 2012. [Accessed January, 2019]. Available from: https://www.guidelinesinpractice.co.uk/smoking-cessation/very-brief-advice-can-be-effective-in-encouraging-smokers-to-quit/337163.article
Diez-Roux AV. On genes, individuals, society, and epidemiology. Am J Epidemiol. 1998;148(11):1027–32.
Sardar Z, Abrams I. Chaos: a graphic guide. London: Icon Books Ltd; 2008.
Davies P. Your uncertain future. In: Brooks M, editor. Chance: the science and secrets of luck, randomness and probability. London: Profile Books, Ltd; 2015.
Zeeman EC. Catastrophe theory. Sci Am. 1976;234(4):65–83.
Thom R. Structural stability and morphogenesis. New York: W.A. Benjamin; 1972.
Gleick J. Chaos: making a new science. New York: Penguin Books; 1987.
Mandelbrot B. How long is the coast of Britain? Statistical self-similarity and fractional dimension. Science. 1967;156:636–8.
Mandelbrot B. The fractal geometry of nature. San Francisco: W.H. Freeman; 1982.
West G. Scale: the universal laws of growth, innovation, sustainability, and the pace of life in organisms, cities, economies, and companies. New York: Penguin Press; 2017.
Oken BS, Charmine I, Wakeland W. A systems approach to stress, stressors and resilience in humans. Behav Brain Res. 2015;282:144–54.
Lovelock JE. The vanishing face of Gaia. New York: Basic Books; 2009.
Moss GE. Illness, immunity, and social interaction: the dynamics of biosocial resonation. New York: Wiley; 1973.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
McDowell, I. (2023). Explanation and Causal Models for Social Epidemiology. In: Understanding Health Determinants. Springer, Cham. https://doi.org/10.1007/978-3-031-28986-6_2
Download citation
DOI: https://doi.org/10.1007/978-3-031-28986-6_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-28985-9
Online ISBN: 978-3-031-28986-6
eBook Packages: MedicineMedicine (R0)