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Clinical Assessment and Management of Chronic Rhinosinusitis with Nasal Polyposis

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Contemporary Rhinology: Science and Practice

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Abstract

Chronic rhinosinusitis (CRS) is a common disease that affects >10% of the adult population in Europe and the USA (Beule, GMS Curr Top Otorhinolaryngol Head Neck Surg 14:Doc11, 2015). It has been delineated into CRS without nasal polyps and CRS with nasal polyps (CRSwNP). Both have a high disease burden and an overlapping spectrum of symptoms such as nasal obstruction, hyposmia, facial pain, pressure and nasal discharge. Great progress has been made in the understanding of CRS pathophysiology.

There is a move towards describing CRS in terms of the predominant endotype, or inflammatory pattern rather than the traditional classification of with and without polyps; the majority of patients with CRSwNP would have a type 2 predominant endotype (Tomassen P et al., J Allergy Clin Immunol 137:1449–1456.e4, 2016). An increased elucidation of the disease endotypes as characterised by their inflammatory pathways and mediators is leading to a tailored treatment approach to the different disease subtypes. Management includes topical and systemic pharmacotherapy, principally corticosteroids, surgery and more recently biologic drugs.

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Further Reading

  • Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology. 2020;58(Suppl S29):1–464.

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Author information

Authors and Affiliations

  1. ENT Department, Guy’s Hospital, London, UK

    Claire Hopkins

  2. Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia

    Jo-Lyn McKenzie

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  1. Claire Hopkins
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  2. Jo-Lyn McKenzie
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Editor information

Editors and Affiliations

  1. Liverpool Head and Neck Centre, Liverpool University Hospitals, Foundation Trust, Liverpool, UK

    Andrew C. Swift

  2. Otolaryngology, Freeman Hospital, Newcastle upon Tyne, Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

    Sean Carrie

  3. Department of Otolaryngology, Tata Memorial Hospital, Mumbai, Maharashtra, India

    Christopher de Souza

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Hopkins, C., McKenzie, JL. (2023). Clinical Assessment and Management of Chronic Rhinosinusitis with Nasal Polyposis. In: Swift, A.C., Carrie, S., de Souza, C. (eds) Contemporary Rhinology: Science and Practice. Springer, Cham. https://doi.org/10.1007/978-3-031-28690-2_25

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  • DOI: https://doi.org/10.1007/978-3-031-28690-2_25

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-28689-6

  • Online ISBN: 978-3-031-28690-2

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