Skip to main content
SpringerLink
Log in

Non-allergic Rhinitis

  • Chapter
  • First Online:
Contemporary Rhinology: Science and Practice

  • 259 Accesses

Abstract

In the current chapter, we will discuss the non-allergic inflammatory phenotype of upper airway pathology. The main objective is to provide practical tips and tricks for proper diagnostic work-up. Afterwards, we will discuss the underlying pathophysiology of specific subgroups, and we will evaluate the different therapeutic options for non-allergic rhinitis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bousquet J, Fokkens W, Burney P, et al. Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper. Allergy. 2008;63:842–53.

    Article  CAS  PubMed  Google Scholar 

  2. Hox V, Delrue S, Scheers H, Adams E, Keirsbilck S, Jorissen M, Hoet PH, Vanoirbeek JA, Nemery B, Hellings PW. Negative impact of occupational exposure on surgical outcome in patients with rhinosinusitis. Allergy. 2012;67:560–5.

    Article  CAS  PubMed  Google Scholar 

  3. Van Gerven L, Boeckxstaens G, Jorissen M, Fokkens W, Hellings PW. Short-time cold dry air exposure: a useful diagnostic tool for nasal hyperresponsiveness. Laryngoscope. 2012;122:2615–20.

    Article  PubMed  Google Scholar 

  4. Segboer C, Gevorgyan A, Avdeeva K, Chusakul S, Kanjanaumporn J, Aeumjaturapat S, Reeskamp LF, Snidvongs K, Fokkens W. Intranasal corticosteroids for non-allergic rhinitis. Cochrane Database Syst Rev. 2019; https://doi.org/10.1002/14651858.CD010592.pub2.

  5. Singh U, Bernstein JA, Haar L, Luther K, Jones WK. Azelastine desensitization of transient receptor potential vanilloid 1: a potential mechanism explaining its therapeutic effect in nonallergic rhinitis. Am J Rhinol Allergy. 2014;28:215–24.

    Article  PubMed  Google Scholar 

  6. Kortekaas Krohn I, Callebaut I, Alpizar YA, et al. MP29-02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite-allergic rhinitis. Allergy. 2018;73:1084–93.

    Article  CAS  PubMed  Google Scholar 

  7. Van Gerven L, Alpizar YA, Wouters MM, Hox V, Hauben E, Jorissen M, Boeckxstaens G, Talavera K, Hellings PW. Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis. J Allergy Clin Immunol. 2014;133:1332–9.

    Article  PubMed  Google Scholar 

  8. Marshak T, Yun WK, Hazout C, Sacks R, Harvey RJ. A systematic review of the evidence base for Vidian neurectomy in managing rhinitis. J Laryngol Otol. 2016;130(Suppl):S7–S28.

    Article  PubMed  Google Scholar 

Further Reading

  • Baptist AP, Nyenhuis S. Rhinitis in the elderly. Immunol Allergy Clin N Am. 2016 May;36(2):343–57.

    Article  Google Scholar 

  • Caparroz FA, Gregorio LL, Bongiovanni G, Izu SC, Kosugi EM. Rhinitis and pregnancy: literature review. Braz J Otorhinolaryngol. 2016;82(1):105–11.

    Article  PubMed  Google Scholar 

  • Cingi C, Ozdoganoglu T, Songu M. Nasal obstruction as a drug side effect. Ther Adv Respir Dis. 2011 Jun;5(3):175–82.

    Article  CAS  PubMed  Google Scholar 

  • Georgalas C, Jovancevic L. Gustatory rhinitis. Curr Opin Otolaryngol Head Neck Surg. 2012 Feb;20(1):9–14.

    Article  PubMed  Google Scholar 

  • González-Díaz SN, Arias-Cruz A, Macouzet-Sánchez C, Partida-Ortega AB. Impact of air pollution in respiratory allergic diseases. Med Univ. 2016 Oct;18(73):212–5.

    Google Scholar 

  • Hellings PW, Klimek L, Cingi C, Agache I, Akdis C, Bachert C, et al. Non-allergic rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2017;72(11):1657–65.

    Article  CAS  PubMed  Google Scholar 

  • Van Gerven L, Steelant B, Hellings PW. Nasal hyperreactivity in rhinitis: a diagnostic and therapeutic challenge. Allergy. 2018;73(9):1784–91.

    Article  PubMed  Google Scholar 

  • Vandenplas O, Hox V, Bernstein D. Occupational rhinitis. J Allergy Clin Immunol Pract. 2020;8(10):3311–21.

    Article  PubMed  Google Scholar 

  • Wahid NWB, Shermetaro C. Rhinitis medicamentosa, vol. 43. StatPearls; 2021. p. 229–33.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium

    Wout Backaert & Laura Van Gerven

  2. Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Unit, KU Leuven, Leuven, Belgium

    Wout Backaert & Laura Van Gerven

  3. Department of Neurosciences, Experimental Otorhinolaryngology, KU Leuven, Leuven, Belgium

    Laura Van Gerven

Authors
  1. Wout Backaert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Laura Van Gerven
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Laura Van Gerven .

Editor information

Editors and Affiliations

  1. Liverpool Head and Neck Centre, Liverpool University Hospitals, Foundation Trust, Liverpool, UK

    Andrew C. Swift

  2. Otolaryngology, Freeman Hospital, Newcastle upon Tyne, Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

    Sean Carrie

  3. Department of Otolaryngology, Tata Memorial Hospital, Mumbai, Maharashtra, India

    Christopher de Souza

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Backaert, W., Van Gerven, L. (2023). Non-allergic Rhinitis. In: Swift, A.C., Carrie, S., de Souza, C. (eds) Contemporary Rhinology: Science and Practice. Springer, Cham. https://doi.org/10.1007/978-3-031-28690-2_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-28690-2_19

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-28689-6

  • Online ISBN: 978-3-031-28690-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation