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The Nose and the Effects of SARS-CoV-2 Pandemic

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Contemporary Rhinology: Science and Practice

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Abstract

This chapter will consider the viral pathogen that has left an indelible mark on our lives and our world and look at the evidence for how it causes its pathophysiology inside the nose, with specific reference to the sense of smell. Although taste buds are not located in the nasal cavity, the chapter will also consider the mechanisms of action of the virus on the sense of taste due to the inherent associations with smell. Finally, the chapter will consider specific therapeutic implications for those affected by COVID-19-related chemosensory disturbances.

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References

  1. Safiabadi Tali SH, LeBlanc JJ, Sadiq Z, Oyewunmi OD, Camargo C, Nikpour B, et al. Tools and techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/COVID-19 detection. Clin Microbiol Rev. 2021;34(3)

    Google Scholar 

  2. Yuen E, Gudis DA, Rowan NR, Nguyen SA, Schlosser RJ. Viral infections of the upper airway in the setting of COVID-19: a primer for rhinologists. Am J Rhinol Allergy. 2021;35(1):122–31.

    Article  PubMed  Google Scholar 

  3. Rockx B, Kuiken T, Herfst S, Bestebroer T, Lamers MM, Oude Munnink BB, et al. Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model. Science. 2020;368(6494):1012–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. McCray PB Jr, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, et al. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol. 2007;81(2):813–21.

    Article  CAS  PubMed  Google Scholar 

  5. Rocke J, Hopkins C, Philpott C, Kumar N. Is loss of sense of smell a diagnostic marker in COVID-19: A systematic review and meta-analysis. Clin Otolaryngol. 2020;45(6):914–22.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Parma V, Ohla K, Veldhuizen MG, Niv MY, Kelly CE, Bakke AJ, et al. More than smell—COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chem Senses. 2020;45(7):609–22.

    Article  CAS  PubMed  Google Scholar 

  7. Lechner M, Liu J, Counsell N, Ta NH, Rocke J, Anmolsingh R, et al. Course of symptoms for loss of sense of smell and taste over time in one thousand forty-one healthcare workers during the Covid-19 pandemic: our experience. Clin Otolaryngol. 2021;46(2):451–7.

    Article  PubMed  Google Scholar 

  8. Brann DH, Tsukahara T, Weinreb C, Lipovsek M, Van den Berge K, Gong B, et al. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci Adv. 2020;6(31)

    Google Scholar 

  9. Pacheco-Herrero M, Soto-Rojas LO, Harrington CR, Flores-Martinez YM, Villegas-Rojas MM, Leon-Aguilar AM, et al. Elucidating the neuropathologic mechanisms of SARS-CoV-2 infection. Front Neurol. 2021;12:660087.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Lim AY, Cheong HK, Oh YJ, Lee JK, So JB, Kim HJ, et al. Modeling the early temporal dynamics of viral load in respiratory tract specimens of COVID-19 patients in Incheon, the Republic of Korea. Int J Infect Dis. 2021;108:428–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Wang H, Liu Q, Hu J, Zhou M, Yu MQ, Li KY, et al. Nasopharyngeal swabs are more sensitive than oropharyngeal swabs for COVID-19 diagnosis and monitoring the SARS-CoV-2 load. Front Med-Lausanne. 2020:7.

    Google Scholar 

  12. Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203(2):631–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Vofo G, Brodie R, Gross M. Nasal lavage containing Angiotensin-Converting Enzyme-2 agonist can prevent and reduce viral load in COVID-19. Med Hypotheses. 2020;144

    Google Scholar 

  14. Matschke J, Lutgehetmann M, Hagel C, Sperhake JP, Schroder AS, Edler C, et al. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol. 2020;19(11):919–29.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Solomon IH, Normandin E, Bhattacharyya S, Mukerji SS, Keller K, Ali AS, et al. Neuropathological features of covid-19. New Engl J Med. 2020;383(10):989–92.

    Article  PubMed  Google Scholar 

  16. Butowt R, von Bartheld CS. Anosmia in COVID-19: underlying mechanisms and assessment of an olfactory route to brain infection. Neuroscientist. 2020;1073858420956905

    Google Scholar 

  17. Lochhead JJ, Thorne RG. Intranasal delivery of biologics to the central nervous system. Adv Drug Deliv Rev. 2012;64(7):614–28.

    Article  CAS  PubMed  Google Scholar 

  18. Bryche B, St Albin A, Murri S, Lacote S, Pulido C, Ar Gouilh M, et al. Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters. Brain Behav Immun. 2020;89:579–86.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Walsh-Messinger J, Kaouk S, Manis H, Kaye R, Cecchi G, Meyer P, et al. Standardized testing demonstrates altered odor detection sensitivity and hedonics in asymptomatic college students as SARS-CoV-2 emerged locally. medRxiv. 2020;

    Google Scholar 

  20. Lee JC, Nallani R, Cass L, Bhalla V, Chiu AG, Villwock JA. A systematic review of the neuropathologic findings of post-viral olfactory dysfunction: implications and novel insight for the COVID-19 pandemic. Am J Rhinol Allergy. 2021;35(3):323–33.

    Article  PubMed  Google Scholar 

  21. Mueller A, Rodewald A, Reden J, Gerber J, von Kummer R, Hummel T. Reduced olfactory bulb volume in post-traumatic and post-infectious olfactory dysfunction. Neuroreport. 2005;16(5):475–8.

    Article  PubMed  Google Scholar 

  22. Rashid RA, Alaqeedy AA, Al-Ani RM. Parosmia due to COVID-19 disease: a 268 case series. Indian J Otolaryngol. 2022;74:2970–7.

    Article  Google Scholar 

  23. Huart C, Philpott C, Konstantinidis I, Altundag A, Whitcroft KL, Trecca EMC, et al. Comparison of COVID-19 and common cold chemosensory dysfunction. Rhinology. 2020;58(6):623–5.

    Article  CAS  PubMed  Google Scholar 

  24. Wang H, Zhou M, Brand J, Huang L. Inflammation and taste disorders: mechanisms in taste buds. Ann N Y Acad Sci. 2009;1170:596–603.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Okada Y, Yoshimura K, Toya S, Tsuchimochi M. Pathogenesis of taste impairment and salivary dysfunction in COVID-19 patients. Jpn Dent Sci Rev. 2021;57:111–22.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. 2020;92(6):552–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Addison AB, Wong B, Ahmed T, Macchi A, Konstantinidis I, Huart C, et al. Clinical Olfactory Working Group consensus statement on the treatment of postinfectious olfactory dysfunction. J Allergy Clin Immunol. 2021;147(5):1704–19.

    Article  CAS  PubMed  Google Scholar 

  28. Hopkins C, Alanin M, Philpott C, Harries P, Whitcroft K, Qureishi A, et al. Management of new onset loss of sense of smell during the COVID-19 pandemic—BRS Consensus Guidelines. Clin Otolaryngol. 2021;46(1):16–22.

    Article  PubMed  Google Scholar 

  29. Huart C, Philpott CM, Altundag A, Fjaeldstad AW, Frasnelli J, Gane S, et al. Systemic corticosteroids in coronavirus disease 2019 (COVID-19)-related smell dysfunction: an international view. Int Forum Allergy Rhinol. 2021;

    Google Scholar 

  30. Webster KE, MacKeith S, Philpott C, Hopkins C, Burton MJ. Interventions for the treatment of persistent post-COVID-19 olfactory dysfunction. Cochrane Database Syst Rev. 2021;2

    Google Scholar 

  31. Philpott C, Dixon J, Boak D. Qualitative olfactory disorders: patient experiences and self-management. Allergy Rhinol (Providence). 2021;12:21526567211004251.

    Article  PubMed  Google Scholar 

  32. Philpott CM, Boardman J, Boak D. Patient experiences of postinfectious olfactory dysfunction. ORL J Otorhinolaryngol Relat Spec. 2021;83:299–303.

    Article  CAS  PubMed  Google Scholar 

  33. Liu DT, Sabha M, Damm M, Philpott C, Oleszkiewicz A, Hähner A, et al. Parosmia is associated with relevant olfactory recovery after olfactory training. Laryngoscope. 2021;131:618–23.

    Article  PubMed  Google Scholar 

  34. Reden J, Mueller A, Mueller C, Konstantinidis I, Frasnelli J, Landis BN, et al. Recovery of olfactory function following closed head injury or infections of the upper respiratory tract. Arch Otolaryngol Head Neck Surg. 2006;132(3):265–9.

    Article  PubMed  Google Scholar 

  35. Hummel T, Whitcroft KL, Andrews P, Altundag A, Cinghi C, Costanzo RM, et al. Position paper on olfactory dysfunction. Rhinol Suppl. 2017;54(26):1–30.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. The Norfolk Smell & Taste Clinic, Norfolk & Waveney ENT Service, Norwich, UK

    Carl Philpott

  2. Norwich Medical School, University of East Anglia, Norwich, UK

    Carl Philpott

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  1. Carl Philpott
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Correspondence to Carl Philpott .

Editor information

Editors and Affiliations

  1. Liverpool Head and Neck Centre, Liverpool University Hospitals, Foundation Trust, Liverpool, UK

    Andrew C. Swift

  2. Otolaryngology, Freeman Hospital, Newcastle upon Tyne, Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

    Sean Carrie

  3. Department of Otolaryngology, Tata Memorial Hospital, Mumbai, Maharashtra, India

    Christopher de Souza

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Philpott, C. (2023). The Nose and the Effects of SARS-CoV-2 Pandemic. In: Swift, A.C., Carrie, S., de Souza, C. (eds) Contemporary Rhinology: Science and Practice. Springer, Cham. https://doi.org/10.1007/978-3-031-28690-2_11

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  • DOI: https://doi.org/10.1007/978-3-031-28690-2_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-28689-6

  • Online ISBN: 978-3-031-28690-2

  • eBook Packages: MedicineMedicine (R0)

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