Skip to main content

Anesthesia for the DLS Patient: Minimizing Risk and Maximizing Safety

  • Chapter
  • First Online:
Functional Limb Salvage
  • 228 Accesses

Abstract

Diabetic limb salvage (DLS) patients present a challenging perioperative course due to comorbidities involving multiple organ systems. These challenges lead to an increased risk of morbidity and mortality in the perioperative period. The demands of the DLS patient population require preoperative medical optimization, intraoperative risk mitigation, and enhanced postoperative recovery.

Surgery induces a stress response throughout multiple organ systems. In a healthy patient, this stress response can be well tolerated; however, DLS patients may not tolerate these same conditions due to medical comorbidities. In order to improve outcomes, DLS patients must have their medical conditions optimized prior to surgery.

Despite medical optimization, the anesthetic technique utilized should cause the fewest physiologic changes in an effort to decrease morbidity and mortality. The options include general anesthesia, regional anesthesia, or a combination of both strategies. The choice of technique should be tailored to each patient.

In the postoperative setting, adequate pain control is essential to reduce morbidity and mortality and improve recovery. The focus should be to prevent and treat Residual Limb Pain (RLP) and Phantom Limb Pain (PLP). An acute pain service (APS) can help achieve this goal using a multitude of medications and interventions such as neuraxial and perineural catheters.

The perioperative surgical home (PSH) was developed to form a multidisciplinary collaboration in the optimization for surgery and postoperative care. Early involvement of anesthesia providers and the acute pain service (APS) are crucial to achieving the goals surrounding this patient population. This collaboration will improve patient outcomes and prove cost-effective for the healthcare system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. American Society of Anesthesiologists. https://www.asahq.org/. Accessed 25 Dec 2020.

  2. Ciocan R-A, et al. Demographic and comorbidity pattern of patients with critical limb ischemia. Folia Med. 2017;59:14–22. https://doi.org/10.1515/folmed-2017-0014.

    Article  CAS  Google Scholar 

  3. Abou-Zamzam A, et al. A prospective analysis of critical limb ischemia: factors leading to major primary amputation versus revascularization. Ann Vasc Surg. 2007;21:458–63. https://doi.org/10.1016/j.avsg.2006.12.006.

    Article  PubMed  Google Scholar 

  4. Fleisher LA, et al. 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery. Circulation. 2014;130(24):e278–333. https://doi.org/10.1161/CIR.0000000000000106.

    Article  PubMed  Google Scholar 

  5. NYSORA. Spinal anesthesia. NYSORA, September 13, 2018. https://www.nysora.com/techniques/neuraxial-and-perineuraxial-techniques/spinal-anesthesia/.

  6. Hajar R. Risk factors for coronary artery disease: historical perspectives. Heart Views. 2017;18(3):109–14. https://doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_106_17.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Lloyd-Jones DM, et al. Use of risk assessment tools to guide decision-making in the primary prevention of atherosclerotic cardiovascular disease. J Am Coll Cardiol. 2019;73(24):3153–67. https://doi.org/10.1016/j.jacc.2018.11.005.

    Article  PubMed  Google Scholar 

  8. Conte MS, et al. Global vascular guidelines on the management of chronic limb-threatening ischemia. Eur J Vasc Endovasc Surg. 2019;58(1):S1–109.e33. https://doi.org/10.1016/j.ejvs.2019.05.006.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Glance LG, et al. Impact of the choice of risk model for identifying low-risk patients using the 2014 American College of Cardiology/American Heart Association perioperative guidelines. Anesthesiology. 2018;129(5):889–900. https://doi.org/10.1097/ALN.0000000000002341.

    Article  PubMed  Google Scholar 

  10. NICE-SUGAR Study Investigators, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360(13):1283–97. https://doi.org/10.1056/NEJMoa0810625.

  11. Hines RL, Marschall KE, editors. Stoelting’s anesthesia and co-existing disease. 7th ed. Philadelphia, PA: Elsevier; 2018.

    Google Scholar 

  12. Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures: an updated report by the American Society of Anesthesiologists Task Force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration. Anesthesiology. 2017;126(3):376–93. https://doi.org/10.1097/ALN.0000000000001452.

  13. Syed AR, Wolfe MM, Calles-Escandon J. Epidemiology and diagnosis of gastroparesis in the United States: a population-based study. J Clin Gastroenterol. 2020;54(1):50–4. https://doi.org/10.1097/MCG.0000000000001231.

    Article  PubMed  Google Scholar 

  14. Jones KL, et al. Predictors of delayed gastric emptying in diabetes. Diabetes Care. 2001;24(7):1264–9. https://doi.org/10.2337/diacare.24.7.1264.

    Article  CAS  PubMed  Google Scholar 

  15. Chung F, et al. Society of Anesthesia and Sleep Medicine Guidelines on preoperative screening and assessment of adult patients with obstructive sleep apnea. Anesth Analg. 2016;123(2):452–73. https://doi.org/10.1213/ANE.0000000000001416.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Adam Law J, et al. The difficult airway with recommendations for management—part 1—difficult tracheal intubation encountered in an unconscious/induced patient. Can J Anaesth. 2013;60(11):1089–118. https://doi.org/10.1007/s12630-013-0019-3.

    Article  PubMed  Google Scholar 

  17. Weibel S, et al. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis. Cochrane Database Syst Rev. 2020;10:CD012859. https://doi.org/10.1002/14651858.CD012859.pub2.

    Article  PubMed  Google Scholar 

  18. NYSORA. Spinal anesthesia.

    Google Scholar 

  19. Levine WC, Massachusetts General Hospital, editors. Handbook of clinical anesthesia procedures of the Massachusetts General Hospital. 8th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2010.

    Google Scholar 

  20. Gogarten W, et al. Regional anaesthesia and antithrombotic agents: recommendations of the European Society of Anaesthesiology. Eur J Anaesthesiol. 2010;27(12):999–1015. https://doi.org/10.1097/EJA.0b013e32833f6f6f.

    Article  CAS  PubMed  Google Scholar 

  21. Levine and Massachusetts General Hospital. Handbook of clinical anesthesia procedures of the Massachusetts General Hospital. Philadelphia: Wolters Kluwer.

    Google Scholar 

  22. Neal JM, et al. The second American Society of Regional Anesthesia and Pain Medicine evidence-based medicine assessment of ultrasound-guided regional anesthesia: executive summary. Reg Anesth Pain Med. 2016;41(2):181–94. https://doi.org/10.1097/AAP.0000000000000331.

    Article  CAS  PubMed  Google Scholar 

  23. Malik O, Brovman EY, Urman RD. The use of regional or neuraxial anesthesia for below-knee amputations may reduce the need for perioperative blood transfusions. Reg Anesth Pain Med. 2018;43(1):25–35. https://doi.org/10.1097/AAP.0000000000000687.

    Article  PubMed  Google Scholar 

  24. Hanyu-Deutmeyer AA, Cascella M, Varacallo M. Phantom limb pain. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2020. http://www.ncbi.nlm.nih.gov/books/NBK448188/.

    Google Scholar 

  25. Srivastava D. Chronic post-amputation pain: peri-operative management—review. Br J Pain. 2017;11(4):192–202. https://doi.org/10.1177/2049463717736492.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Cascella H-D, Varacallo. Phantom limb pain.

    Google Scholar 

  27. Luo Y, Anderson TA. Phantom limb pain: a review. Int Anesthesiol Clin. 2016;54(2):121–39. https://doi.org/10.1097/AIA.0000000000000095.

    Article  PubMed  Google Scholar 

  28. Cohen SP, Raja SN. Pathogenesis, diagnosis, and treatment of lumbar zygapophysial (facet) joint pain. Anesthesiology. 2007;106(3):591–614. https://doi.org/10.1097/00000542-200703000-00024.

    Article  PubMed  Google Scholar 

  29. Noguchi S, et al. Factors affecting phantom limb pain in patients undergoing amputation: retrospective study. J Anesth. 2019;33(2):216–20. https://doi.org/10.1007/s00540-018-2599-0.

    Article  PubMed  Google Scholar 

  30. Luo, Anderson. Phantom limb pain.

    Google Scholar 

  31. McCormick Z, et al. Phantom limb pain: a systematic neuroanatomical-based review of pharmacologic treatment. Pain Med. 2014;15(2):292–305. https://doi.org/10.1111/pme.12283.

    Article  PubMed  Google Scholar 

  32. Maria JM, Alviar TH, Lim-Dungca M. Pharmacologic interventions for treating phantom limb pain. Cochrane Database Syst Rev. 2016;10:CD006380. https://doi.org/10.1002/14651858.CD006380.pub3.

    Article  Google Scholar 

  33. Sahin SH, et al. A retrospective trial comparing the effects of different anesthetic techniques on phantom pain after lower limb amputation. Curr Ther Res Clin Exp. 2011;72(3):127–37. https://doi.org/10.1016/j.curtheres.2011.06.001.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Ong BY, Arneja A, Ong EW. Effects of anesthesia on pain after lower-limb amputation. J Clin Anesth. 2006;18(8):600–4. https://doi.org/10.1016/j.jclinane.2006.03.021.

    Article  PubMed  Google Scholar 

  35. Cho H-S, et al. Effects of different anesthetic techniques on the incidence of phantom limb pain after limb amputation: a population-based retrospective cohort study. Korean J Pain. 2020;33(3):267–74. https://doi.org/10.3344/kjp.2020.33.3.267.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Jahangiri M, et al. Prevention of phantom pain after major lower limb amputation by epidural infusion of diamorphine, clonidine and bupivacaine. Ann R Coll Surg Engl. 1994;76(5):324–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Karanikolas M, et al. Optimized perioperative analgesia reduces chronic phantom limb pain intensity, prevalence, and frequency: a prospective, randomized, clinical trial. Anesthesiology. 2011;114(5):1144–54. https://doi.org/10.1097/ALN.0b013e31820fc7d2.

    Article  CAS  PubMed  Google Scholar 

  38. Rathmell JP, Kehlet H. Do we have the tools to prevent phantom limb pain? Anesthesiology. 2011;114(5):1021–4. https://doi.org/10.1097/ALN.0b013e31820fc80d.

    Article  PubMed  Google Scholar 

  39. Srivastava. Chronic post-amputation pain.

    Google Scholar 

  40. Kent ML, et al. Perioperative pain management strategies for amputation: a topical review. Pain Med. 2017;18(3):504–19. https://doi.org/10.1093/pm/pnw110.

    Article  PubMed  Google Scholar 

  41. Nikolajsen L, et al. Randomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limb amputation. Lancet. 1997;350(9088):1353–7. https://doi.org/10.1016/S0140-6736(97)06315-0.

    Article  CAS  PubMed  Google Scholar 

  42. Ata A, et al. Postoperative hyperglycemia and surgical site infection in general surgery patients. Arch Surg. 2010;145(9):858–64. https://doi.org/10.1001/archsurg.2010.179.

    Article  PubMed  Google Scholar 

  43. Bomberg H, et al. Prolonged catheter use and infection in regional anesthesia: a retrospective registry analysis. Anesthesiology. 2018;128(4):764–73. https://doi.org/10.1097/ALN.0000000000002105.

    Article  PubMed  Google Scholar 

  44. Caricato A, Antonelli M. Colonization, contamination, or infection in perineural catheters: how to discriminate? Minerva Anestesiol. 2018;84(3):292–3. https://doi.org/10.23736/S0375-9393.17.12418-1.

    Article  PubMed  Google Scholar 

  45. Aveline C, et al. Perineural ultrasound-guided catheter bacterial colonization: a prospective evaluation in 747 cases. Reg Anesth Pain Med. 2011;36(6):579–84. https://doi.org/10.1097/AAP.0b013e31822e665a.

    Article  PubMed  Google Scholar 

  46. Elhassan A, et al. Perioperative surgical home models and enhanced recovery after surgery. J Anaesthesiol Clin Pharmacol. 2019;35(Suppl 1):S46–50. https://doi.org/10.4103/joacp.JOACP_47_18.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Kash BA, et al. The perioperative surgical home (PSH): a comprehensive review of US and non-US studies shows predominantly positive quality and cost outcomes. Milbank Q. 2014;92(4):796–821. https://doi.org/10.1111/1468-0009.12093.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Zaccagnino MP, et al. The perioperative surgical home: a new role for the acute pain service. Anesth Analg. 2017;125(4):1394–402. https://doi.org/10.1213/ANE.0000000000002165.

    Article  PubMed  Google Scholar 

Further Reading

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kasra Razmjou .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Razmjou, K., Liao, A. (2023). Anesthesia for the DLS Patient: Minimizing Risk and Maximizing Safety. In: Attinger, C.E., Steinberg, J.S. (eds) Functional Limb Salvage. Springer, Cham. https://doi.org/10.1007/978-3-031-27725-2_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-27725-2_11

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-27724-5

  • Online ISBN: 978-3-031-27725-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics