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Radiation Therapies in Cancer

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Therapeutic Approaches in Cancer Treatment

Part of the book series: Cancer Treatment and Research ((CTAR,volume 185))

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Abstract

A crucial element of cancer treatment is radiation therapy that is used to destroy tumors and cancer cells through radiation. Another essential component is immunotherapy that helps immune system to combat cancer. The combination of both radiation therapy and immunotherapy is being focused recently for the treatment of many tumors. Chemotherapy includes the use of some chemical agent to control the growth of cancer, whereas irradiation involves the use of radiations of high energy to kill cancer cells. The union of both became the strongest practice in cancer treatment techniques. Specific chemotherapies are combined with radiation in the treatment of cancer after proper preclinical assessment of their effectiveness. Some classes of compounds include platinum-based drugs, antimicrotubules, antimetabolites (5-Fluorouracil, Capecitabine, Gemcitabine, Pemetrexed), topoisomerase I inhibitors, alkylating agents (Temozolomide), and other agents (Mitomycin-C, Hypoxic Sensitizers, Nimorazole).

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References

  1. Committee for Radiation Oncology Studies (1986) Criteria for radiation oncology in multidisciplinary cancer management: report to the director of the National Cancer Institute, National Institutes of Health. American College of Radiology, Philadelphia

    Google Scholar 

  2. Baumann M, Krause M, Hill R (2008) Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer 8(7):545–554

    Article  CAS  PubMed  Google Scholar 

  3. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57–70

    Article  CAS  PubMed  Google Scholar 

  4. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674

    Article  CAS  PubMed  Google Scholar 

  5. Balmain A, Gray J, Ponder B (2003) The genetics and genomics of cancer. Nat Genet 33(3):238–244

    Article  CAS  PubMed  Google Scholar 

  6. Brenner DJ, Hall EJ (1999) Fractionation and protraction for radiotherapy of prostate carcinoma. Int J Radiat Oncol* Biol* Phys 43(5):1095–1101

    Google Scholar 

  7. Trialists’ Group TS (2008) The UK Standardisation of breast radiotherapy (START) trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet 371(9618):1098–1107

    Google Scholar 

  8. Jain RK (2014) Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell 26(5):605–622

    Article  CAS  PubMed  Google Scholar 

  9. Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473(7347):298–307

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Less JR, Skalak TC, Sevick EM, Jain RK (1991) Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Can Res 51(1):265–273

    CAS  Google Scholar 

  11. Butler TP, Grantham FH, Gullino PM (1975) Bulk transfer of fluid in the interstitial compartment of mammary tumors. Can Res 35(11):3084–3088

    CAS  Google Scholar 

  12. Weis SM, Cheresh DA (2005) Pathophysiological consequences of VEGF-induced vascular permeability. Nature 437(7058):497–504

    Article  CAS  PubMed  Google Scholar 

  13. Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK (2011) Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 91(3):1071–1121

    Article  CAS  PubMed  Google Scholar 

  14. Jain RK (1987) Transport of molecules across tumor vasculature. Cancer Metastasis Rev 6(4):559–593

    Article  CAS  PubMed  Google Scholar 

  15. Carmeliet P, Jain RK (2011) Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 10(6):417–427

    Article  CAS  PubMed  Google Scholar 

  16. McCormick F (2001) New-age drug meets resistance. Nature 412(6844):281–282

    Article  CAS  PubMed  Google Scholar 

  17. Sharp HJ, Wansley EK, Garnett CT, Chakraborty M, Camphausen K, Schlom J, Hodge JW (2007) Synergistic antitumor activity of immune strategies combined with radiation. Front Biosci 12:4900–4910

    Article  CAS  PubMed  Google Scholar 

  18. Kwilas A, Donahue RN, Bernstein MB, Hodge JW (2012) In the field: exploiting the untapped potential of immunogenic modulation by radiation in combination with immunotherapy for the treatment of cancer. Front Oncol 2:104–114

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Thompson RH, Kurta JM, Kaag M, Tickoo SK, Kundu S, Katz D, Russo P (2009) Tumor size is associated with malignant potential in renal cell carcinoma cases. J Urol 181(5):2033–2036

    Article  PubMed  Google Scholar 

  20. American Cancer Society (2017) Cancer facts and figures 2017, vol 2017. American Cancer Society, Atlanta, GA

    Google Scholar 

  21. Muscat JE, Hoffmann D, Wynder EL (1995) The epidemiology of renal cell carcinoma. A second look. Cancer 75(10):2552–2557

    Article  CAS  PubMed  Google Scholar 

  22. Gordon SC, Moonka D, Brown KA, Rogers C, Huang MAY, Bhatt N, Lamerato L (2010) Risk for renal cell carcinoma in chronic hepatitis C infection. Cancer Epidemiol Prev Biomark 19(4):1066–1073

    Article  CAS  Google Scholar 

  23. Pathology and genetics of tumours of the urinary system and male genital organs (2004). IARC Press, Lyon, France

    Google Scholar 

  24. Olgac S, Mazumdar M, Dalbagni G, Reuter VE (2004) Urothelial carcinoma of the renal pelvis: a clinicopathologic study of 130 cases. Am J Surg Pathol 28(12):1545–1552

    Article  PubMed  Google Scholar 

  25. Charbit L, Gendreau MC, Mee S, Cukier J (1991) Tumors of the upper urinary tract: 10 years of experience. J Urol 146(5):1243–1246

    Article  CAS  PubMed  Google Scholar 

  26. Montie JE, Stewart BH, Straffon RA, Banowsky LH, Hewitt CB, Montague DK (1977) The role of adjunctive nephrectomy in patients with metastatic renal cell carcinoma. J Urol 117(3):272–275

    Article  CAS  PubMed  Google Scholar 

  27. Gibbons RP, Montie JE, Correa RJ Jr, Mason JT (1976) Manifestations of renal cell carcinom. Urology 8(3):201–206

    Article  CAS  PubMed  Google Scholar 

  28. McClennan BL (1991) Oncologic imaging. Staging and follow‐up of renal and adrenal carcinoma. Cancer 67(S4):1199–1208

    Google Scholar 

  29. Pantuck AJ, Zisman A, Dorey F, Chao DH, Han KR, Said J, Figlin RA (2003) Renal cell carcinoma with retroperitoneal lymph nodes: impact on survival and benefits of immunotherapy. Cancer 97(12):2995–3002

    Article  PubMed  Google Scholar 

  30. Vasselli JR, Yang JC, Linehan WM, White DE, Rosenberg SA, Walther MM (2001) Lack of retroperitoneal lymphadenopathy predicts survival of patients with metastatic renal cell carcinoma. J Urol 166(1):68–72

    Article  CAS  Google Scholar 

  31. Akdogan B, Dogan HS, Eskicorapci SY, Sahin A, Erkan I, Ozen H (2006) Prognostic significance of bladder tumor history and tumor location in upper tract transitional cell carcinoma. J Urol 176(1):48–52

    Article  PubMed  Google Scholar 

  32. Mullerad M, Russo P, Golijanin D, Chen HN, Tsai HH, Donat SM, Dalbagni G (2004) Bladder cancer as a prognostic factor for upper tract transitional cell carcinoma. J Urol 172(6 Part 1):2177–2181

    Google Scholar 

  33. Toker C (1972) Trabecular carcinoma of the skin. Arch Dermatol 105(1):107–110

    Article  CAS  PubMed  Google Scholar 

  34. Evans HL, Smith JL (1980) Spindle cell squamous carcinomas and sarcoma‐like tumors of the skin. A comparative study of 38 cases. Cancer, 45(10):2687–2697

    Google Scholar 

  35. Goepfert H, Remmler D, Silva E, Wheeler B (1984) Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck. Arch Otolaryngol 110(11):707–712

    Article  CAS  PubMed  Google Scholar 

  36. Mendenhall WM, Kirwan JM, Morris CG, Amdur RJ, Werning JW, Mendenhall NP (2012) Cutaneous Merkel cell carcinoma. Am J Otolaryngol 33(1):88–92

    Article  PubMed  Google Scholar 

  37. Mojica P, Smith D, Ellenhorn JD (2007) Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin. J Clin Oncol 25(9):1043

    Article  PubMed  Google Scholar 

  38. Kaufman RS (1985) Million RR, Cassisi NJ (eds) Management of head and neck cancer: a multidiscilinary approach, JB Lippincott, Philadelphia (1985), 681 pages, $97.50

    Google Scholar 

  39. Million RR (1989) The myth regarding bone or cartilage involvement by cancer and the likelihood of cure by radiotherapy. Head Neck 11(1):30–40

    Article  CAS  PubMed  Google Scholar 

  40. Mendenhall WM, Amdur RJ, Hinerman RW, Cognetta AB, Mendenhall NP (2009) Radiotherapy for cutaneous squamous and basal cell carcinomas of the head and neck. Laryngoscope 119(10):1994–1999

    Article  PubMed  Google Scholar 

  41. Veness MJ, Morgan GJ, Palme CE, Gebski V (2005) Surgery and adjuvant radiotherapy in patients with cutaneous head and neck squamous cell carcinoma metastatic to lymph nodes: combined treatment should be considered best practice. Laryngoscope 115(5):870–875

    Article  PubMed  Google Scholar 

  42. Schulte KW, Lippold A, Auras C, Bramkamp G, Breitkopf C, Elsmann HJ, Suter L (2005) Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas. J Am Acad Dermatol 53(6):993–1001

    Article  PubMed  Google Scholar 

  43. Rosenthal DI, Asper JA, Barker JL Jr, Garden AS, Chao KC, Morrison WH, Ang KK (2006) Importance of patient examination to clinical quality assurance in head and neck radiation oncology. Head Neck J Sci SpecTies Head Neck 28(11):967–973

    Article  Google Scholar 

  44. Gunther JR, Liauw SL, Choi S, Mohamed AS, Thaker NG, Fuller CD, Golden DW (2016) A prostate fossa contouring instructional module: implementation and evaluation. J Am Coll Radiol 13(7):835–841

    Article  PubMed Central  Google Scholar 

  45. Berman AT, Plastaras JP, Vapiwala N (2013) Radiation oncology: a primer for medical students. J Cancer Educ 28(3):547–553

    Article  PubMed  Google Scholar 

  46. World Health Organization (1958) Introduction of radiation medicine into the undergraduate medical curriculum: fifth report of the expert committee on professional and technical education of medical and auxiliary personnel [meeting held in Geneva from 25 to 30 November 1957]. World Health Organization

    Google Scholar 

  47. Corn BW, Symon Z, Gamzu R (2014) The state of radiation therapy in the state of Israel. Int J Radiat Oncol Biol Phys 90:975–978

    Article  PubMed  Google Scholar 

  48. Bordage G, Harris I (2011) Making a difference in curriculum reform and decision-making processes. Med Educ 45(1):87–94

    Article  PubMed  Google Scholar 

  49. Davis DA, Thomson MA, Oxman AD, Haynes RB (1992) Evidence for the effectiveness of CME: a review of 50 randomized controlled trials. JAMA 268(9):1111–1117

    Article  CAS  PubMed  Google Scholar 

  50. Hayes J, Jackson JL, McNutt GM, Hertz BJ, Ryan JJ, Pawlikowski SA (2014) Association between physician time-unlimited vs time-limited internal medicine board certification and ambulatory patient care quality. JAMA 312(22):2358–2363

    Article  CAS  PubMed  Google Scholar 

  51. Gray BM, Vandergrift JL, Johnston MM, Reschovsky JD, Lynn LA, Holmboe ES, Lipner RS (2014) Association between imposition of a maintenance of certification requirement and ambulatory care–sensitive hospitalizations and health care costs. JAMA 312(22):2348–2357

    Article  CAS  PubMed  Google Scholar 

  52. Joo JH, Kim YS, Cho BC, Jeong CY, Park W, Kim HJ, Kim JY (2017) Variability in target delineation of cervical carcinoma: a Korean radiation oncology group study (KROG 15–06). PLoS One 12(3):e0173476

    Article  PubMed Central  Google Scholar 

  53. Clayton R, Trotter T (2013) The impact of undergraduate education in radiation oncology. J Cancer Educ 28(1):192–196

    Article  PubMed  Google Scholar 

  54. Reich WT (1994) The word “bioethics”: its birth and the legacies of those who shaped it. Kennedy Inst Ethics J 4(4):319–335

    Article  CAS  PubMed  Google Scholar 

  55. Beauchamp TL, Childress JF (2001) Principles of biomedical ethics. Oxford University Press, USA

    Google Scholar 

  56. Kitamura T (2005) Natanson v. Kline, 350 P. 2d 1093 Kan, 1960. Psychiatry Clin Neurosci 59(6):627–633

    Google Scholar 

  57. Lyons AS, Petrucelli RJ (1978) Medicine: an illustrated history. Hong Kong: Abrams 1987:207–217

    Google Scholar 

  58. Pellegrino ED (1986) Percival’s medical ethics: the moral philosophy of an 18th-century English gentleman. Arch Intern Med 146(11):2265–2269

    Article  CAS  PubMed  Google Scholar 

  59. Brotherton S, Kao A, Crigger BJ (2016) Professing the values of medicine: the modernized AMA Code of Medical Ethics. JAMA 316(10):1041–1042

    Article  PubMed  Google Scholar 

  60. Dunn CM, Chadwick GL (2002) Protecting study volunteers in research: a manual for investigative sites. CenterWatch, Boston, MA

    Google Scholar 

  61. Riley BD, Culver JO, Skrzynia C, Senter LA, Peters JA, Costalas JW, Trepanier AM (2012) Essential elements of genetic cancer risk assessment, counseling, and testing: updated recommendations of the National Society of Genetic Counselors. J Genet Couns 21(2):151–161

    Article  PubMed  Google Scholar 

  62. Halperin EC (1988) X-rays at the bar, 1896–1910. Invest Radiol 23(8):639–646

    Article  CAS  PubMed  Google Scholar 

  63. Tangka FK, Trogdon JG, Richardson LC, Howard D, Sabatino SA, Finkelstein EA (2010) Cancer treatment cost in the United States: has the burden shifted over time? Cancer 116(14):3477–3484

    Article  PubMed  Google Scholar 

  64. Centers for Medicare and Medicaid Services. CMS National Health Expenditures 2015. https://www.cms.gov/research-statisticsdata-and-systems/statistics-trends-andreports/nationalhealthexpenddata/nationalhealthaccountshistorical.html

  65. Shen X, Showalter TN, Mishra MV, Barth S, Rao V, Levin D, Parker L (2014) Radiation oncology services in the modern era: evolving patterns of usage and payments in the office setting for Medicare patients from 2000 to 2010. J Oncol Pract 10(4):e201–e207

    Article  Google Scholar 

  66. American Society for Radiation Oncology. APEx program guidance. American Society for Radiation. https://www.astro.org/uploadedFiles/Main_Site/Practice_Management/Practice_Accrediation/PublishedJanuary 2015. Last Accessed 1 Apr 2017

  67. Donabedian A (2005) Evaluating the quality of medical care. Milbank Q 83(4):691.69

    Google Scholar 

  68. Luo J, Solimini NL, Elledge SJ (2009) Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136(5):823–837

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Mohyeldin A, Garzón-Muvdi T, Quiñones-Hinojosa A (2010) Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 7(2):150–161

    Google Scholar 

  70. Trédan O, Galmarini CM, Patel K, Tannock IF (2007) Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst 99(19):1441–1454

    Article  PubMed  Google Scholar 

  71. Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379(6560):88–91

    Article  CAS  PubMed  Google Scholar 

  72. Lin CH, Pelissier FA, Zhang H, Lakins J, Weaver VM, Park C, LaBarge MA (2015) Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors. Mol Biol Cell 26(22):3946–3953

    Article  CAS  PubMed Central  Google Scholar 

  73. Patenaude A, Parker J, Karsan A (2010) Involvement of endothelial progenitor cells in tumor vascularization. Microvasc Res 79(3):217–223.76

    Google Scholar 

  74. Ahn GO, Brown JM (2009) Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature. Angiogenesis 12(2):159–164

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. Ahn GO, Brown JM (2008) Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell 13(3):193–205

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Ahn GO, Tseng D, Liao CH, Dorie MJ, Czechowicz A, Brown JM (2010) Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment. Proc Natl Acad Sci 107(18):8363–8368

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Josson S, Sharp S, Sung SY, Johnstone PA, Aneja R, Wang R, Yates C (2010) Tumor-stromal interactions influence radiation sensitivity in epithelial-versus mesenchymal-like prostate cancer cells. J Oncol

    Google Scholar 

  78. Tsai KK, Stuart J, Chuang YYE, Little JB, Yuan ZM (2009) Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant. Radiat Res 172(3):306–313

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Korc M (2007) Pancreatic cancer–associated stroma production. Am J Surg 194(4):S84–S86

    Article  CAS  PubMed  Google Scholar 

  80. Butcher DT, Alliston T, Weaver VM (2009) A tense situation: forcing tumour progression. Nat Rev Cancer 9(2):108–122

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Kelkar SS, Reineke TM (2011) Theranostics: combining imaging and therapy. Bioconjug Chem 22(10):1879–1903

    Article  CAS  PubMed  Google Scholar 

  82. Hofer KG (1996) Biophysical aspects of Auger processes. Acta Oncol 35(7):789–796

    Article  CAS  PubMed  Google Scholar 

  83. Milenic DE, Brady ED, Brechbiel MW (2004) Antibody-targeted radiation cancer therapy. Nat Rev Drug Discov 3(6):488–499

    Article  CAS  PubMed  Google Scholar 

  84. Parker C, Zhan L, Cislo P, Reuning-Scherer J, Vogelzang NJ, Nilsson S, Coleman RE (2017) Effect of radium-223 dichloride (Ra-223) on hospitalisation: an analysis from the phase 3 randomised alpharadin in symptomatic prostate cancer patients (ALSYMPCA) trial. Eur J Cancer 71:1–6

    Google Scholar 

  85. Croke J, Leung E, Segal R, Malone S (2012) Clinical benefits of alpharadin in castrate-chemotherapy-resistant prostate cancer: case rep bcr2012006540

    Google Scholar 

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Authors and Affiliations

  1. Department of Food Sciences, University of the Punjab, Quid-I-Azam Campus, Lahore, Pakistan

    Muhammad Rizwan Tariq, Shinawar Waseem Ali, Noor Fatima & Aqsa Jabeen

  2. Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan

    Asma Saleem Qazi

  3. Department of Diet and Nutritional Sciences, Ibadat International University, Islamabad, Pakistan

    Amna Hameed

  4. Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan

    Waseem Safdar

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  1. Muhammad Rizwan Tariq
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  2. Shinawar Waseem Ali
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Correspondence to Muhammad Rizwan Tariq .

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Editors and Affiliations

  1. Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan

    Asma Saleem Qazi

  2. Respiratory Medicine, Castle Hill Hospital, Cottingham, UK

    Kanwal Tariq

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Tariq, M.R. et al. (2023). Radiation Therapies in Cancer. In: Qazi, A.S., Tariq, K. (eds) Therapeutic Approaches in Cancer Treatment. Cancer Treatment and Research, vol 185. Springer, Cham. https://doi.org/10.1007/978-3-031-27156-4_4

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