Abstract
Cancer is a complex disease. According to the Globocan survey, 63% deaths are due to cancer. There are some conventional methods that are used to treat cancer. However, certain treatment modalities are under clinical trials still. The success of treatment depends on type and stage of cancer, locality, and patient’s response to that specific treatment. Most widely used treatments are surgery, radiotherapy, and chemotherapy. Personalized treatment approach has some promising effects, yet some of the points are still unclear. This chapter has provided the overview of some of the therapeutic modalities; however, the therapeutic potential has been discussed in details throughout the book.
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References
Ames BN, Gold LS, Willett WC (1995) The causes and prevention of cancer. Proc Natl Acad Sci USA 92(12):5258–5265. https://doi.org/10.1073/pnas.92.12.5258
Anel M, Steller E, Esus J et al (2000) Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343:1350–1354
M Arruebo N Vilaboa B Sáez-Gutierrez J Lambea A Tres M Valladares Á González-Fernández (2011) Assessment of the evolution of cancer treatment therapies. Cancers 3(3):3279–3330. https://doi.org/10.3390/cancers3033279
Bhosle J, Hall G (2009) Principles of cancer treatment by chemotherapy. Surgery 27(4):173–177. https://doi.org/10.1016/j.mpsur.2009.01.006
Burrell R, McGranahan N, Bartek J et al (2013) The causes and consequences of genetic heterogeneity in cancer evolution. Nature 501:338–345. https://doi.org/10.1038/nature12625
Burrell R, McGranahan N, Bartek J et al (2013b) The causes and consequences of genetic heterogeneity in cancer evolution. Nature 501:338–345. https://doi.org/10.1038/nature12625
Chargaria C, Giraudb T, Lacorneriec T, Cosset JM (2022) Prevention of radiation-induced cancers. Cancer/Radiothérapie 26(1–2):92–95. https://doi.org/10.1016/j.canrad.2021.09.005
Caine GJ, Stonelake PS, Rea D, Lip GYH (2003) Coagulopathic complications in breast cancer. Cancer 98(8):1578–1586. https://doi.org/10.1002/CNCR.11702
Carmeliet P, Jain R (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473:298–307. https://doi.org/10.1038/nature10144
Carmeliet P, Jain R (2011) Molecular mechanisms and clinical applications of angiogenesisno title. Nature 473:298–307. https://doi.org/10.1038/nature10144
Chang DK, Hohenforst W, Wu H-C, Chang D-K, Huang C-T (2013) Targeted-therapy for cancer related papers. J Cancer Mol
Chatterjee DK, Fong LS, Zhang Y (2008) Nanoparticles in photodynamic therapy: an emerging paradigm. Adv Drug Deliv Rev 60(15):1627–1637. https://doi.org/10.1016/j.addr.2008.08.003
DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB (2008) The Biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7(1):11–20. https://doi.org/10.1016/j.cmet.2007.10.002
DeVita VT, Chu E (2008) A history of cancer chemotherapy. Can Res 68(21):8643–8653. https://doi.org/10.1158/0008-5472.CAN-07-6611
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365(9472):1687–1717
Elion GB, Singer S, Hitchings GH (1954) Antagonists of nucleic acid derivatives. J Biol Chem 208(2):477–488. https://doi.org/10.1016/s0021-9258(18)65573-5
Hall EJ (2006) Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol* Biol* Phys 65 (1):1–7. https://doi.org/10.1016/j.ijrobp.2006.01.027
Farber S, Diamond LK, Mercer RD, Sylvester Jr RF, Wolff JA (1948) Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin). N Engl J Med 238(23):787–793. https://www.nejm.org/doi/full/https://doi.org/10.1056/NEJM192802231980115
Fogh SE, Andrews DW, Glass J, Curran W, Glass C, Champ C, Evans JJ et al (2010) Hypofractionated stereotactic radiation therapy: an effective therapy for recurrent high-grade gliomas. J Clin Oncol 28(18):30–48
Gilman A (1946) Therapeutic applications of chemical warfare agents. Fed Proc 5:285–292. https://www.semanticscholar.org/paper/Therapeutic-applications-of-chemical-warfare-Gilman/57644fe19040136a57deca51c078ffd672b93666#paper-header
Gupta T, Agarwal J, Jain S, Phurailatpam R, Kannan S, Ghosh-Laskar S, Murthy V et al (2012) Three-dimensional conformal radiotherapy (3D-CRT) versus intensity modulated radiation therapy (IMRT) in squamous cell carcinoma of the head and neck: a randomized controlled trial. Radiother Oncol 104 (3): 343–48. https://doi.org/10.1016/j.radonc.2012.07.001
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674. https://doi.org/10.1016/j.cell.2011.02.013
Hanly AM, Hayanga A, Winter DC, Bouchier-Hayes DJ (2005) Thrombomodulin: tumour biology and prognostic implications. Eur J Surg Oncol (EJSO) 31(3):217–220. https://doi.org/10.1016/J.EJSO.2004.11.017
Hassen-Khodja R (2004) Gamma knife and linear accelerator stereotactic radiosurgery. Agence d’évaluation Des Technologies et Des Modes d’intervention En Santé
Heidelberger C, Chaudhuri NK, Danneberg P, Mooren D, Griesbach L, Duschinsky R, Schnitzer RJ, Pleven E, Scheiner J (1957) Title: fluorinated pyrimidines, a new class of tumour-inhibitory compounds. Nature 179:663–666. https://doi.org/10.1038/179663a0
Hozumi N, Tonegawa S (1976) Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc Natl Acad Sci USA 73(10):3628–3632. https://doi.org/10.1073/pnas.73.10.3628
Huang X, Jain PK, El-Sayed IH et al (2008) Lasmonic photothermal therapy (PPTT) using gold nanoparticles. Lasers Med Sci 23(217). https://doi.org/10.1007/s10103-007-0470-x
Jensen SB, Jarvis V, Zadik Y, Barasch A, Ariyawardana A, Hovan A, Yarom N, Lalla RV, Bowen J, Elad S (2013) Systematic review of miscellaneous agents for the management of oral mucositis in cancer patients. Support Care Cancer 21(11):3223–3232. https://doi.org/10.1007/s00520-013-1884-6
Johnson IS, Armstrong JG, Gorman M, Paul Burnett J (1963) The vinca alkaloids: a new class of oncolytic agents. Can Res 23(77):1390–1427
Kano H, Flickinger JC, Tonetti D, Hsu A, Yang HC, Flannery TJ, Niranjan A, Dade Lunsford L (2017) Estimating the risks of adverse radiation effects after gamma knife radiosurgery for arteriovenous malformations. Stroke 48(1):84–90. https://doi.org/10.1161/STROKEAHA.116.014825
Kantelhardt EJ, Vetter M, Schmidt M, Veyret C, Augustin D, Hanf V, Meisner C et al (2011) Prospective evaluation of prognostic factors UPA/PAI-1 in node-negative breast cancer: phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6 × FEC versus 3 × FEC/3 × Docetaxel. BMC Cancer 11(1):1–10. https://doi.org/10.1186/1471-2407-11-140
Li MC, Hertz R, Bergenstal DM (1958) Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and purine antagonists. N Engl J Med 259(2):66–74
Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120(2):237–248. https://doi.org/10.1016/j.cell.2004.11.046
Moore P, Chang Y (2010) Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer 878–889. https://doi.org/10.1038/nrc2961
Moore PS, Feng H, Chang Y, Shuda M (2008) Clonal integration of a polyomavirus in human merkel cell carcinoma. Science 319(5866):1096–1100
Nakamura N, Shikama N, Oguchi M (2010). Intensity-modulated radiation therapy (IMRT). Jpn J Clin Med 68(6):1035–1039
Oshiro Y, Takeda Y, Hirano S, Ito H, Aruga T (2011) Role of radiotherapy for local control of asymptomatic adrenal metastasis from lung cancer. Am J Clin Oncol Cancer Clin Trials 34(3):249–253. https://doi.org/10.1097/COC.0b013e3181dbb727
Pardal R, Clarke M, Morrison S (2003) Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 3:895–902
Pavlova NN, Thompson CB (2016) The emerging hallmarks of cancer metabolism. Cell Metab 23(1):27–47. https://doi.org/10.1016/j.cmet.2015.12.006
Pearson OH, Eliel LP, Rawson RW, Dobriner K, Rhoads CP (1949) This study was undertaken to determine whether the rate of growth of various types of neoplastic tissues in man would be influenced by increasing adrenal cortical function. In: Kendall (n.d.) “Cancer-November 1949-Pearson-Acth‐and Cortisone‐induced regression of Lymphoid tumors in man”. A preliminary report
Picot J, Cooper K, Bryant J, Clegg AJ (2011) The clinical effectiveness and cost-effectiveness of bortezomib and thalidomide in combination regimens with an alkylating agent and a corticosteroid for the first-line treatment of multiple myeloma: a systematic review and economic evaluation. https://doi.org/10.3310/hta15410
Ralph SJ, Rodríguez-Enríquez S, Neuzil J, Saavedra E, Moreno-Sánchez R (2010) The causes of cancer revisited: ‘mitochondrial malignancy’ and ROS-induced oncogenic transformation-why mitochondria are targets for cancer therapy Mol Aspects Med 31(2):145–170. https://doi.org/10.1016/j.mam.2010.02.008
Raty JK, Pikkarainen JT, Wirth T, Yla-Herttuala S (2008) Gene therapy: the first approved gene-based medicines, molecular mechanisms and clinical indications. Curr Mol Pharmacol 1(1):13–23
Rehman S, Abbas Z (2018) An overview of cancer treatment modalities. https://doi.org/10.5772/intechopen.76558
Rodgers GM, Becker PS, Blinder M, Cella D, Chanan-Khan A, Cleeland C, Coccia PF et al (2012) Cancer-and chemotherapy-induced anemia. J Natl Compr Canc Netw 10(5):628–653. https://doi.org/10.6004/jnccn.2012.0064
Shi J, Votruba AR, Farokhzad OC, Langer R (2010) Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett 10(9):3223–3323
Shojaei F (2012) Anti-angiogenesis therapy in cancer: current challenges and future perspectives. Cancer Lett 320(2):130–137. https://doi.org/10.1016/j.canlet.2012.03.008
Timmerman RD, Xing L (2012) Image-guided and adaptive radiation therapy. Lippincott Williams & Wilkins
Wagner A, Ploder O, Enislidis G, Truppe M, Ewers R (1995) Virtual image guided navigation in tumor surgery—technical innovation. J Cranio-Maxillofac Surg 23(5):271–273. https://doi.org/10.1016/S1010-5182(05)80155-6
Wang M, Thanou M (2010) Targeting nanoparticles to cancer. Pharmaological Res 62(2):90–99
Xing RH, Rabbani SA (1999) Transcriptional regulation of urokinase (uPA) gene expression in breast cancer cells: role of DNA methylation. Int J Cancer 81:443–450. https://doi.org/10.1002/(SICI)1097-0215(19990505)81:3
Zhang L, Gu FX, Chan JM, Wang AZ, Langer RS, Farokhzad OC (2007) Nanoparticles in medicine: therapeutic applications and developments. Clin Pharmacol Theapeutics 83(5):761–769
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Qazi, A.S. (2023). Introduction and Overview of Cancer Therapeutics. In: Qazi, A.S., Tariq, K. (eds) Therapeutic Approaches in Cancer Treatment. Cancer Treatment and Research, vol 185. Springer, Cham. https://doi.org/10.1007/978-3-031-27156-4_1
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