Abstract
Treating cancers is challenging due to tumor heterogeneity and off-target toxicities of existing therapeutics. Hundreds of genetic variations associated with human disease have been identified that contribute to the disparate treatment responses seen among individual patients. Additionally, lack of efficacy because of dose-limiting toxicities is another major bottleneck in developing effective drugs for cancer treatment. To remedy these challenges, personalized treatment strategies combined with localized drug delivery platforms offer a promising approach. Notably, localized delivery of chemotherapeutics reduces systemic adverse effects, prevents dose-limiting toxicities, and enables effective chemotherapeutic treatment. To this end, three-dimensional (3D) printing of materials is a viable route for manufacturing personalized drug delivery systems with precise control over spatiotemporal drug distribution. This chapter will overview the various 3D-printed therapeutics currently being used for localized cancer treatment.
Keywords
- 3D printing
- Cancer
- Localized drug delivery
- 3D bioprinting
- Tumor
- Anticancer delivery
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- 3D:
-
Three-dimensional
- ABS:
-
Acrylonitrile butadiene styrene
- CAD:
-
Computer-aided design
- CMC:
-
Carboxymethyl cellulose sodium
- CSBT:
-
Conformal superficial brachytherapy
- CT:
-
Computerized tomography
- DLP:
-
Digital light processing
- DNA:
-
Deoxyribonucleic acid
- E-jet:
-
Electrohydrodynamic jet
- FDM:
-
Fused deposition modeling
- GelMA:
-
Gelatin methacryloyl
- GO:
-
Graphene oxide
- MN:
-
Microneedle
- MNA:
-
Microneedle arrays
- NIR:
-
Near-infrared
- PCL:
-
Polycaprolactone
- PLA:
-
Polylactic acid
- PLGA:
-
Poly(lactic-co-glycolic acid)
- PLLA:
-
Poly(L-lactic acid)
- PPF:
-
Poly(propylene fumarate)
- PTX:
-
Paclitaxel
- rBMSCs:
-
Rat bone marrow mesenchymal stem cells
- ROS:
-
Reactive oxygen species
- SEM:
-
Scanning electron microscopy
- SLA:
-
Stereolithography
- SLS:
-
Selective laser sintering
- TMZ:
-
Temozolomide
- TNF:
-
Tumor necrosis factor
- TRAIL:
-
Tumor necrosis factor-related apoptosis-inducing ligand
- UV:
-
Ultraviolet
- UV-LED:
-
Ultraviolet light-emitting diodes
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The authors would like to thank the Natural Sciences and Engineering Research Council of Canada (NSERC) for their financial support.
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Razzaghi, M., Seyfoori, A., Akbari, M. (2023). 3D Printing for Localized Cancer Therapy. In: Lamprou, D. (eds) Nano- and Microfabrication Techniques in Drug Delivery . Advanced Clinical Pharmacy - Research, Development and Practical Applications, vol 2. Springer, Cham. https://doi.org/10.1007/978-3-031-26908-0_8
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