Abstract
The current availability of dosage forms for patients with special requirements, such as pediatrics, is low while often leading to poor acceptability and inadequate treatment adherence. As a result, unlicensed and off-labeled preparations are common, exposing patients to unpredictable risks. During the last years, there is an obvious momentum for drug development tailored to such patient groups, with 3D printing being at the forefront of research in this area. In this context, semi-solid extrusion 3D printing, with the unique capability of additive manufacturing without requiring extreme temperatures, is paving the way toward personalized medicine, point-of-care fabrication upon demand, and digitalization of the pharmaceutical industry.
Keywords
- 3D printing
- Semi-solid extrusion
- Personalized medicine
- Special groups
- Patient compliance
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- 3DP:
-
Three-dimensional Printing
- API:
-
Active Pharmaceutical Ingredient
- CAD:
-
Computer-Aided Design
- CMC:
-
Carboxymethylcellulose
- FDA:
-
Food and Drug Administration
- FDM:
-
Fused Deposition Modelling
- HPC:
-
Hydroxypropyl Cellulose
- HPMC:
-
Hydroxypropyl Methylcellulose
- LEV:
-
Levetiracetam
- MSUD:
-
Maple Syrup Urine Disease
- ODF:
-
Orodispersible Film
- ODT:
-
Orodispersible Tablet
- PLGA:
-
Poly Lactic-co-Glycolic Acid
- PS:
-
Pregelatinized Starch
- PVA:
-
Polyvinyl Alcohol
- PVP:
-
Polyvinyl Pyrrolidone
- QbD:
-
Quality by Design
- SPG:
-
Special Patient Group
- SSE:
-
Semi-Solid Extrusion
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Gkaragkounis, A., Fatouros, D.G. (2023). Semi-solid Extrusion 3D Printing for the Development of Dosage Forms for Special Patient Groups. In: Lamprou, D. (eds) Nano- and Microfabrication Techniques in Drug Delivery . Advanced Clinical Pharmacy - Research, Development and Practical Applications, vol 2. Springer, Cham. https://doi.org/10.1007/978-3-031-26908-0_6
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