Nasal Drug Delivery Systems for the Treatment of Diseases of the Central Nervous System and Tuberculosis

Nhung Vu, Thi Hong; Morozkina, Svetlana; Snetkov, Petr; Uspenskaya, Mayya

doi:10.1007/978-3-031-26908-0_16

Thi Hong Nhung Vu³,
Svetlana Morozkina³,
Petr Snetkov³ &
…
Mayya Uspenskaya³

Part of the book series: Advanced Clinical Pharmacy - Research, Development and Practical Applications ((ACPRDPA,volume 2))

489 Accesses

Abstract

Nasal drug delivery is a current drug delivery trend that is gaining attraction, especially for respiratory and central nervous system (CNS) diseases. This delivery pathway avoids the undesirable effects of systemic drug delivery, such as excessive dosing, damage to non-diseased organs, or drug destruction before reaching the therapeutic target. Inhaled drugs have been used for therapeutic and recreational purposes since ancient times. The development of modern inhalers for drug delivery has increased the use of intranasal drugs. More than ever, the development of drug-integrated intranasal formulations is extremely promising, providing hope for the treatment of diseases previously thought to be difficult to treat, such as tuberculosis or central nervous system diseases. Numerous investigations of intranasal formulations have been studied and published by pharmacologists over the years. The majority of research products are nanocapsules such as nanoparticles, micelles, liposomes, sol-gels, emulsions, and microspheres. Targeted drug formulations are created based on the features of the disease, the cell’s characteristics, the nature of the cell environment, and the biochemical barriers that the drug has to overcome. Preclinical and clinical assays of drug formulations help to determine their applicability in patients by the examination of their physicochemical properties, drug release, and pharmacokinetics. In this review, we focus on the factors that influence the nasal drug delivery, as well as drug release in the studies of tuberculosis and CNS formulations.

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Abbreviations

AUC :: Area under the curve
CF:: 5(6)-Carboxyfluorescein
C_max:: Maximum drug concentration
CNS:: Central nervous system
CS:: Chitosan
DDPC:: Dipalmitoyl phosphatidylcholine
DH:: Diphenhydramine hydrochloride
DMPC:: Dimilystoylphosphatidylcholine
DOPE:: 1,2-Dioleoyl-sn-glycero3-phosphoethanolamine
DOTAP:: 1,2-Dioleoyl-3-trimethylammonium-propane
DSC:: Differential scanning calorimetry
EE:: Encapsulation efficiency
EPC:: Egg phosphatidylcholine
FTIR:: Fourier-transform infrared
HA:: Hyaluronic acid
HPLC:: High-performance liquid chromatography
INU/pArg:: Inulin/polyarginine
LC:: Loading capacity
LE:: Licorice extract
MC:: Mannosylated chitosan
MMDA :: Mass median aerodynamic diameter
OZ:: Olanzapine
PBS :: Phosphate-buffered solution
PDI:: Polydispersity index
PLGA:: Poly(lactic-co-glycolic acid)
PVA:: Poly(vinyl alcohol)
TC:: Thiolated chitosan
TFM:: Teriflunomide
T_max:: Time required to reach maximum drug concentration
WGA:: Wheat germ agglutinin
XRD:: X-ray diffraction
ZP:: Zeta potential

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Chemical Engineering Centre, ITMO University, St. Petersburg, Russia
Thi Hong Nhung Vu, Svetlana Morozkina, Petr Snetkov & Mayya Uspenskaya

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Svetlana Morozkina
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School of Pharmacy, Queen’s University Belfast, Belfast, UK
Dimitrios Lamprou

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Nhung Vu, T.H., Morozkina, S., Snetkov, P., Uspenskaya, M. (2023). Nasal Drug Delivery Systems for the Treatment of Diseases of the Central Nervous System and Tuberculosis. In: Lamprou, D. (eds) Nano- and Microfabrication Techniques in Drug Delivery . Advanced Clinical Pharmacy - Research, Development and Practical Applications, vol 2. Springer, Cham. https://doi.org/10.1007/978-3-031-26908-0_16

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