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Evaluation and Treatment of Exertional Heat Illness, Rhabdomyolysis, and Hyponatremia

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Endurance Sports Medicine

Abstract

Exertional heat illness (EHI) and exertional rhabdomyolysis (ER) are seen in athletes and military members due to repetitive, intense, and/or prolonged exercise. An athlete who is experiencing the most severe form of EHI, known as exertional heat stroke (EHS), must be identified and removed from activity immediately, as well as provided aggressive, on-site whole body cooling in order to improve their likelihood of survival. Most EHI and EHS can be prevented with proper heat acclimatization, work/rest ratios, and hydration. Exertional rhabdomyolysis is diagnosed when severe muscle symptoms are accompanied by laboratory evidence of myonecrosis (CK > 5× upper limit of normal) in the setting or recent exertion. ER may range from mild to severe and accordingly may be treated as an outpatient or inpatient. Core principles of care include rest, aggressive hydration, and monitoring for complications. Also seen in endurance sports, exercise-associated hyponatremia is a potential mimicker of EHI that must be recognized. It is typically seen in novice athletes undergoing prolonged exercise who feel that they need to hydrate frequently. Treatment of mild cases includes hypotonic fluid restriction and administration of oral broth. More severe cases require one or more boluses of 3% saline and possibly admission to intensive care.

No financial disclosures were reported by the authors of this paper.

The opinions herein are those of the authors. They do not represent the official policy of the Department of Defense or any of its components.

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References

  1. Bramble DM, Lieberman DE. Endurance running and the evolution of homo. Nature. 2004;432(7015):345–52.

    Article  CAS  PubMed  Google Scholar 

  2. Roberts WO, Armstrong LE, Sawka MN, Yeargin SW, Heled Y, O'Connor FG. ACSM expert consensus statement on exertional heat illness: recognition, management, and return to activity. Curr Sports Med Rep. 2021;20(9):470–84.

    Article  PubMed  Google Scholar 

  3. Casa DJ, DeMartini JK, Bergeron MF, Csillan D, Eichner ER, Lopez RM, et al. National Athletic Trainers' association position statement: exertional heat illnesses. J Athl Train. 2015;50(9):986–1000.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Miller KC, McDermott BP, Yeargin SW, Fiol A, Schwellnus MP. An evidence-based review of the pathophysiology, treatment, and prevention of exercise associated muscle cramps. J Athl Train. 2022;57(1):5–15.

    Article  PubMed  Google Scholar 

  5. Gamage PJ, Fortington LV, Finch CF. Epidemiology of exertional heat illnesses in organised sports: a systematic review. J Sci Med Sport. 2020;23(8):701–9.

    Article  PubMed  Google Scholar 

  6. Casa DJ, Armstrong LE, Kenny GP, O'Connor FG, Huggins RA. Exertional heat stroke: new concepts regarding cause and care. Curr Sports Med Rep. 2012;11(3):115–23.

    Article  PubMed  Google Scholar 

  7. Walter E, Steel K. Management of exertional heat stroke: a practical update for primary care physicians. Br J Gen Pract. 2018;68(668):153–4.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Hunter DJ, Frumkin H, Jha A. Preventive medicine for the planet and its peoples. N Engl J Med. 2017;376(17):1605–7.

    Article  PubMed  Google Scholar 

  9. Bouscaren N, Faricier R, Millet GY, Racinais S. Heat acclimatization, cooling strategies, and hydration during an ultra-trail in warm and humid conditions. Nutrients. 2021;13(4):1085.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Bouchama A, Abuyassin B, Lehe C, Laitano O, Jay O, O'Connor FG, et al. Classic and exertional heatstroke. Nat Rev Dis Primers. 2022;8(1):8.

    Article  PubMed  Google Scholar 

  11. Casa DJ, McDermott BP, Lee EC, Yeargin SW, Armstrong LE, Maresh CM. Cold water immersion: the gold standard for exertional heatstroke treatment. Exerc Sport Sci Rev. 2007;35(3):141–9.

    Article  PubMed  Google Scholar 

  12. Knapik JJ, Epstein Y. Exertional heat stroke: pathophysiology, epidemiology, diagnosis, treatment, and prevention. J Spec Oper Med. 2019;19(2):108–16.

    Article  PubMed  Google Scholar 

  13. Hosokawa Y, Adams WM, Belval LN, Vandermark LW, Casa DJ. Tarp-assisted cooling as a method of whole-body cooling in Hyperthermic individuals. Ann Emerg Med. 2017;69(3):347–52.

    Article  PubMed  Google Scholar 

  14. Demartini JK, Casa DJ, Stearns R, Belval L, Crago A, Davis R, et al. Effectiveness of cold water immersion in the treatment of exertional heat stroke at the Falmouth road race. Med Sci Sports Exerc. 2015;47(2):240–5.

    Article  PubMed  Google Scholar 

  15. Asplund CA, O'Connor FG. Challenging return to play decisions: heat stroke, exertional rhabdomyolysis, and exertional collapse associated with sickle cell trait. Sports Health. 2016;8(2):117–25.

    Article  PubMed  Google Scholar 

  16. TB MED 507/Air Force Pamphlet 48–152. Heat stress control and heat casualty management. Headquarters department of the army and air force; 2003.

    Google Scholar 

  17. O'Connor FG, Grunberg NE, Harp JB, Deuster PA. Exertion-related illness: the critical roles of leadership and followership. Curr Sports Med Rep. 2020;19(1):35–9.

    Article  PubMed  Google Scholar 

  18. Hew-Butler T, Loi V, Pani A, Rosner MH. Exercise-associated hyponatremia: 2017 update. Front Med (Lausanne). 2017;4:21.

    PubMed  Google Scholar 

  19. Hew-Butler T, Rosner MH, Fowkes-Godek S, Dugas JP, Hoffman MD, Lewis DP, et al. Statement of the 3rd international exercise-associated hyponatremia consensus development conference, Carlsbad, California, 2015. Br J Sports Med. 2015;49(22):1432–46.

    Article  PubMed  Google Scholar 

  20. Oh RC, Malave B, Chaltry JD. Collapse in the heat–from Overhydration to the emergency room–three cases of exercise-associated hyponatremia associated with exertional heat illness. Mil Med. 2018;183(3–4):e225–e8.

    Article  PubMed  Google Scholar 

  21. Anonymous. Update: exertional hyponatremia, active component, U.S. armed forces, 2005-2020. MSMR. 2021;28(4):21–6.

    Google Scholar 

  22. Armstrong LE, Casa DJ, Watson G. Exertional hyponatremia. Curr Sports Med Rep. 2006;5(5):221–2.

    Article  PubMed  Google Scholar 

  23. Bennett BL, Hew-Butler T, Rosner MH, Myers T, Lipman GS. Wilderness medical society clinical practice guidelines for the Management of Exercise-Associated Hyponatremia: 2019 update. Wilderness Environ Med. 2020;31(1):50–62.

    Article  PubMed  Google Scholar 

  24. Kenefick RW. Drinking strategies: planned drinking versus drinking to thirst. Sports Med. 2018;48(Suppl 1):31–7.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Hoffman MD. Proper hydration during ultra-endurance activities. Sports Med Arthrosc Rev. 2019;27(1):8–14.

    Article  PubMed  Google Scholar 

  26. McDermott BP, Anderson SA, Armstrong LE, Casa DJ, Cheuvront SN, Cooper L, et al. National Athletic Trainers' association position statement: fluid replacement for the physically active. J Athl Train. 2017;52(9):877–95.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Nye NS, Kasper K, Madsen CM, Szczepanik M, Covey CJ, Oh R, et al. Clinical practice guidelines for exertional rhabdomyolysis: a military medicine perspective. Curr Sports Med Rep. 2021;20(3):169–78.

    Article  PubMed  Google Scholar 

  28. Szczepanik ME, Heled Y, Capacchione J, Campbell W, Deuster P, O'Connor FG. Exertional rhabdomyolysis: identification and evaluation of the athlete at risk for recurrence. Curr Sports Med Rep. 2014;13(2):113–9.

    Article  PubMed  Google Scholar 

  29. Tietze DC, Borchers J. Exertional rhabdomyolysis in the athlete: a clinical review. Sports Health. 2014;6(4):336–9.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Anonymous. Update: exertional rhabdomyolysis, active component, U.S. armed forces, 2016-2020. MSMR. 2021;28(4):16–20.

    Google Scholar 

  31. Luetmer MT, Boettcher BJ, Franco JM, Reisner JH, Cheville AL, Finnoff JT. Exertional rhabdomyolysis: a retrospective population-based study. Med Sci Sports Exerc. 2020;52(3):608–15.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Halldorsson AB, Benedikz E, Olafsson I, Mogensen B. Visits of patients with exertional rhabdomyolysis to the emergency Department at Landspitali, the National University Hospital of Iceland in the years 2008-2012. Laeknabladid. 2016;102(3):131–5.

    PubMed  Google Scholar 

  33. Heytens K, De Ridder W, De Bleecker J, Heytens L, Baets J. Exertional rhabdomyolysis: relevance of clinical and laboratory findings, and clues for investigation. Anaesth Intensive Care. 2019;47(2):128–33.

    Article  PubMed  Google Scholar 

  34. Kenney K, Landau ME, Gonzalez RS, Hundertmark J, O'Brien K, Campbell WW. Serum creatine kinase after exercise: drawing the line between physiological response and exertional rhabdomyolysis. Muscle Nerve. 2012;45(3):356–62.

    Article  CAS  PubMed  Google Scholar 

  35. Landau ME, Kenney K, Deuster P, Campbell W. Exertional rhabdomyolysis: a clinical review with a focus on genetic influences. J Clin Neuromuscul Dis. 2012;13(3):122–36.

    Article  PubMed  Google Scholar 

  36. Cervellin G, Comelli I, Benatti M, Sanchis-Gomar F, Bassi A, Lippi G. Non-traumatic rhabdomyolysis: background, laboratory features, and acute clinical management. Clin Biochem. 2017;50(12):656–62.

    Article  PubMed  Google Scholar 

  37. Lippi G, Schena F, Ceriotti F. Diagnostic biomarkers of muscle injury and exertional rhabdomyolysis. Clin Chem Lab Med. 2018;57(2):175–82.

    Article  PubMed  Google Scholar 

  38. Oh RC, Arter JL, Tiglao SM, Larson SL. Exertional rhabdomyolysis: a case series of 30 hospitalized patients. Mil Med. 2015;180(2):201–7.

    Article  PubMed  Google Scholar 

  39. McMahon GM, Zeng X, Waikar SS. A risk prediction score for kidney failure or mortality in rhabdomyolysis. JAMA Intern Med. 2013;173(19):1821–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Nielsen JS, Sally M, Mullins RJ, Slater M, Groat T, Gao X, et al. Bicarbonate and mannitol treatment for traumatic rhabdomyolysis revisited. Am J Surg. 2017;213(1):73–9.

    Article  PubMed  Google Scholar 

  41. Atias D, Druyan A, Heled Y. Recurrent exertional rhabdomyolysis: coincidence, syndrome, or acquired myopathy? Curr Sports Med Rep. 2013;12(6):365–9.

    Article  PubMed  Google Scholar 

  42. O'Connor FG, Brennan FH Jr, Campbell W, Heled Y, Deuster P. Return to physical activity after exertional rhabdomyolysis. Curr Sports Med Rep. 2008;7(6):328–31.

    Article  PubMed  Google Scholar 

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Romick, J., Balogun, R., Nye, N. (2023). Evaluation and Treatment of Exertional Heat Illness, Rhabdomyolysis, and Hyponatremia. In: Miller, T.L. (eds) Endurance Sports Medicine. Springer, Cham. https://doi.org/10.1007/978-3-031-26600-3_5

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  • DOI: https://doi.org/10.1007/978-3-031-26600-3_5

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