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Gender Susceptibility and Comorbidities in COVID-19 Headache

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Headache Disorders in Pandemic Conditions

Part of the book series: Headache ((HEAD))

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Abstract

COVID-19 mostly affects patients in the middle-to-advanced age group, where chronic comorbid diseases are also seen. There are limited studies on comorbidities accompanying COVID-19 infection and their frequency. Early detection and knowledge of comorbid conditions associated with COVID-19 infection facilitate patient management. The rate of transmission, symptoms, and prognosis of COVID-19 infection differ between the sexes. There are different statements about the distribution of the frequency of headache, which is a common symptom during infection, between the sexes. In this regard, the underlying chromosomal, hormonal conditions, and different behavior patterns between the genders are emphasized.

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References

  1. Caronna E, Ballvé A, Llauradó A, Gallardo VJ, Ariton DM, Lallana S, et al. Headache: a striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution. Cephalalgia. 2020 Nov;40(13):1410–21.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Trigo J, García-Azorín D, Planchuelo-Gómez Á, Martínez-Pías E, Talavera B, Hernández-Pérez I, et al. Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study. J Headache Pain. 2020;21(1):94.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Gonzalez-Martinez A, Fanjul V, Ramos C, Serrano Ballesteros J, Bustamante M, et al. Headache during SARS-CoV-2 infection as an early symptom associated with a more benign course of disease: a case-control study. Eur J Neurol. 2021;28(10):3426–36.

    Article  PubMed  Google Scholar 

  4. Rocha-Filho PAS, Magalhães JE. Headache associated with COVID-19: frequency, characteristics and association with anosmia and ageusia. Cephalalgia. 2020;40(13):1443–51.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Ferrario Carlos M, Jessup J, Chappell MC. Effect of angiotensin converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005;111(20):2605e10.

    Google Scholar 

  6. Kuster GM, Otmar P, Thilo B, Qian Z, Raphael T, Philip H, et al. Sarscov 2: should inhibitors of the renin-angiotensin system be withdrawn in patients with covid-19? Eur Heart J. 2020;41:1801.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ejaz H, Alsrhani A, Zafar A, Javed H, Junaid K, Abdalla AE, Abosalif KOA, Ahmed Z, Younas S. COVID-19 and comorbidities: deleterious impact on infected patients. J Infect Public Health. 2020;13(12):1833–9.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Anjos D, de Paula RC, de Maria Frota Vasconcelos T, da Costa FBS, de Brito LA, Torres DM, AEF M, et al. Characterization of headache in COVID-19: a retrospective multicenter study. Mol Neurobiol. 2021;58(9):4487–94.

    Article  Google Scholar 

  9. Karadaş Ö, Öztürk B, Sonkaya AR, Taşdelen B, Özge A, Bolay H. Latent class cluster analysis identified hidden headache phenotypes in COVID-19: impact of pulmonary infiltration and IL-6. Neurol Sci. 2021;42(5):1665–73.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Gasmi A, Peana M, Pivina L, Srinath S, Gasmi Benahmed A, Semenova Y, Menzel A, Dadar M, Bjørklund G. Interrelations between COVID-19 and other disorders. Clin Immunol. 2021;224:108651.

    Article  CAS  PubMed  Google Scholar 

  11. Fernandez C, Rysa J, Almgren P, Nilsson J, Engstrom G, Orho-Melander M, et al. Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality. J Intern Med. 2018;284(4):377–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Shang J, Wan Y, Luo C, Ye G, Geng Q, Auerbach A, et al. Cell entry mechanisms of SARS-CoV-2. Proc Natl Acad Sci U S A. 2020;117(21):11727–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Steenblock C, Richter S, Berger I, Barovic M, Schmid J, Schubert U, et al. Viral infiltration of pancreatic islets in patients with COVID-19. Nat Commun. 2021;12(1):3534.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Porta-Etessam J, Matías-Guiu JA, González-García N, Gómez Iglesias P, Santos-Bueso E, Arriola-Villalobos P, et al. Spectrum of headaches associated with SARS-CoV-2 infection: study of healthcare professionals. Headache. 2020;60(8):1697–704.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Guo J, Huang Z, Lin L, Lv J. Coronavirus disease 2019 (COVID-19) and cardiovascular disease: a viewpoint on the potential influence of angiotensin- converting enzyme inhibitors/angiotensin receptor blockers on onset and severity of severe acute respiratory syndrome coronavirus 2 infection. J Am Heart Assoc. 2020;9(7):e016219.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Leung JM, Yang CX, Tam A, Shaipanich T, Hackett TL, Singhera GK, Dorscheid DR, Sin DD. ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19. Eur Respir J. 2020;55(5):2000688.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Ozge A, Ozge C, Kaleagasi H, Yalin OO, Unal O, Ozgür ES. Headache in patients with chronic obstructive pulmonary disease: effects of chronic hypoxaemia. J Headache Pain. 2006;7(1):37–43.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Kömüs N, Tertemiz KC, Sevinç C. KOAH riski altında olan (Evre 0) olguların önemi ve klinik farklılıkları. Tuberk Toraks. 2008;56:382–9.

    PubMed  Google Scholar 

  19. Haider MZ, Al-Mannai A, Al-Sirhan S, Elsabagh A, Nasser N, Al-Quraishi N, et al. Impact of smoking on COVID-19 symptoms in non-vaccinated patients: a matched observational study from Qatar. J Multidiscip Healthc. 2022;15:531–40.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Kabbani N, Olds JL. Does COVID19 infect the brain? If so, smokers might be at a higher risk. Mol Pharmacol. 2020;97(5):351–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Goadsby PJ, Holland PR, Martins-Oliveira M, Hoffmann J, Schankin C, Akerman S. Pathophysiology of migraine: a disorder of sensory processing. Physiol Rev. 2017;97(2):553–622.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Balogh M, Aguilar C, Nguyen NT, Shepherd AJ. Angiotensin receptors and neuropathic pain. Pain Rep. 2021;6(1):e869.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Rocha-Filho PAS, Magalhaes JE. Headache associated with COVID-19: frequency, characteristics and association with anosmia and ageusia. Cephalalgia. 2020;40:1443–51.

    Google Scholar 

  24. Membrilla JA, de Lorenzo Í, Sastre M, Díaz de Terán J. Headache as a cardinal symptom of coronavirus disease 2019: a cross-sectional study. Headache. 2020;60(10):2176–91.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Uygun Ö, Ertaş M, Ekizoğlu E, Bolay H, Özge A, Kocasoy Orhan E, Çağatay AA, Baykan B. Headache characteristics in COVID-19 pandemic-a survey study. J Headache Pain. 2020;21(1):121.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Lakbar I, Luque-Paz D, Mege JL, Einav S, Leone M. COVID-19 gender susceptibility and outcomes: a systematic review. PLoS One. 2020;15(11):e0241827.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Mukherjee S, Pahan K. Is COVID-19 gender-sensitive? J Neuroimmune Pharmacol. 2021;16(1):38–47. https://doi.org/10.1007/s11481-020-09974-z. (Epub 2021 Jan 6. PMID: 33405098; PMCID: PMC7786186.2- Cai H. Sex difference and smoking predisposition in patients with COVID-19. Lancet Respir Med. 2020;8:e20).

  28. Nemoto W, Nakagawasai O, Yaoita F, Kanno S, Yomogida S, Ishikawa M, et al. Angiotensin II produces nociceptive behavior through spinal AT1 receptor-mediated p38 mitogen-activated protein kinase activation in mice. Mol Pain. 2013;9:38. https://doi.org/10.1186/1744-8069-9-38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Berletch JB, Yang F, Xu J, Carrel L, Disteche CM. Genes that escape from X inactivation. Hum Genet. 2011;130(2):237–45.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Foresta C, Rocca MS, Di Nisio A. Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome. J Endocrinol Investig. 2021;44(5):951–6.

    Article  CAS  Google Scholar 

  31. Cai H. Sex difference and smoking predisposition in patients with COVID-19. Lancet Respir Med. 2020;8(4):e20. https://doi.org/10.1016/S2213-2600(20)30117-X.

  32. Al-Hashel JY, Abokalawa F, Alenzi M, Alroughani R, Ahmed SF. Coronavirus disease-19 and headache; impact on pre-existing and characteristics of de novo: a cross-sectional study. J Headache Pain. 2021;22(1):97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Toptan T, Aktan Ç, Başarı A, Bolay H. Case series of headache characteristics in COVID-19: headache can be an isolated symptom. Headache. 2020;60(8):1788–92.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Senst L, Baimoukhametova D, Sterley TL, Bains JS. Sexually dimorphic neuronal responses to social isolation. elife. 2016;5:e18726.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Levkovich I, Shinan-Altman S. The impact of gender on emotional reactions, perceived susceptibility and perceived knowledge about COVID-19 among the Israeli public. Int Health. 2021;13(6):555–61.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Bolay H, Karadas Ö, Oztürk B, Sonkaya R, Tasdelen B, Bulut TDS, et al. HMGB1, NLRP3, IL-6 and ACE2 levels are elevated in COVID-19 with headache: a window to the infection-related headache mechanism. J Headache Pain. 2021;22(1):94.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Fernández-de-Las-Peñas C, Martín-Guerrero JD, Pellicer-Valero ÓJ, Navarro- Pardo E, Gómez-Mayordomo V, Cuadrado ML, et al. Female sex is a risk factor associated with long-term post-COVID related-symptoms but not with COVID-19 symptoms: the long-COVID-EXP-CM multicenter study. J Clin Med. 2022;11(2):413.

    Article  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neurology, Sakarya University Training and Research Hospital, Sakarya, Turkey

    Dilcan Kotan & Saadet Sayan

  2. Department of Neurology, Akyazı State Hospital, Sakarya, Turkey

    Esen Çiçekli

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  1. Dilcan Kotan
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  2. Esen Çiçekli
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  3. Saadet Sayan
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Editor information

Editors and Affiliations

  1. Department of Neurology, Mersin University Faculty of Medicine, Mersin, Türkiye

    Aynur Özge

  2. Neurology, Brain 360-Brain Health Center, Istanbul, Türkiye

    Derya Uludüz

  3. Dept of Neurology & Algology, NÖROM, Neuropsychiatry Center, Gazi University, Ankara, Türkiye

    Hayrunnisa Bolay

  4. Department of Neurology, Gülhane Faculty of Medicine, Ankara, Türkiye

    Ömer Karadaş

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Kotan, D., Çiçekli, E., Sayan, S. (2023). Gender Susceptibility and Comorbidities in COVID-19 Headache. In: Özge, A., Uludüz, D., Bolay, H., Karadaş, Ö. (eds) Headache Disorders in Pandemic Conditions . Headache. Springer, Cham. https://doi.org/10.1007/978-3-031-26309-5_10

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  • DOI: https://doi.org/10.1007/978-3-031-26309-5_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-26308-8

  • Online ISBN: 978-3-031-26309-5

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