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Scabies-Associated Microbiota

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Scabies

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Abstract

Globally, scabies causes substantial morbidity and mortality. In the tropics, scabies promotes opportunistic bacterial infections, leading to cellulitis/necrotising fasciitis, bacteraemia, kidney disease and/or rheumatic heart disease. With no vaccine or diagnostic tools and limited treatment options, scabies is considered neglected by the World Health Organization (WHO). Pathobiology is poorly understood, due to an absence of molecular information on mite infestation, bacterial co-infection and the interactions thereof. In providing quantitative, community-wide and potentially longitudinal data sets, skin microbiota research could be a powerful methodology for further exploration. Analysing the scabies-associated microbiome, i.e., the combined genetic material of the microorganisms in scabies infected skin samples, could provide fundamental insights into the interaction between the human host, mites and the microorganisms co-existing with them. By focussing in particular on opportunistic bacterial pathogens, it may be possible to develop novel diagnostic and/or therapeutic tools for this disease complex.

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Authors and Affiliations

  1. Research Group Dynamic, EA7380, Faculté de Santé, Université Paris-Est, EnvA, USC ANSES, Créteil, France

    Charlotte Bernigaud

  2. Dermatology Department, AP-HP, Hôpital Henri Mondor, Université Paris-Est, Créteil, France

    Charlotte Bernigaud

  3. Scabies Laboratory, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia

    Sara Taylor & Katja Fischer

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  2. Sara Taylor
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Correspondence to Katja Fischer .

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Editors and Affiliations

  1. QIMR Berghofer Medical Research Institut, Herston, QLD, Australia

    Katja Fischer

  2. UPE-Université Paris-Est, Service de Dermatologie, Hôpital Henri Mondor, EA 7379 EpiDermE et INSERM CIC 1430, Créteil, France

    Olivier Chosidow

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Bernigaud, C., Taylor, S., Fischer, K. (2023). Scabies-Associated Microbiota. In: Fischer, K., Chosidow, O. (eds) Scabies. Springer, Cham. https://doi.org/10.1007/978-3-031-26070-4_7

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