Abstract
This chapter summarizes the iatrogenic causes of the four primary acid–base disorders. Metabolic acidosis can develop from certain drugs by (1) generating endogenous acids such as lactic acid; (2) loss of bicarbonate from the gastrointestinal tract or kidney; and (3) impairing kidney tubular function. A number of drugs such as diuretics cause metabolic alkalosis. Drugs such as anesthetics, sedatives, or opiates cause respiratory acidosis, whereas salicylates or progesterone can cause respiratory alkalosis.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Suggested Reading
Brater DG. Drug-induced electrolyte disorders and use of diuretics. In: Kokko JP, Tannen RL, editors. Fluids and electrolytes. Philadelphia: W.B. Saunders Company; 1996. p. 693–728.
Holt CT, Hitchings AW. Drug-induced metabolic acidosis. Adverse Drug React Bull. 2017:No.304.
Kitterer D, Schwab M, Dominik M, et al. Drug-induced acid-base disorders. Pediatr Nephrol. 2015;30:1407–23.
Pham AQT, Xu LHR, Moe OW. Drug-induced metabolic acidosis. F1000Research. 2015:1–13.
Wiener SM. Toxicologic acid-base disorders. Emerg Med Clin N Am. 2014;32:149–65.
Wilson KC, Saukkonen JJ. Acute respiratory failure from abused substances. J Intensive Care Med. 2004;19:183–93.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Reddi, A.S. (2023). Drug-Induced Acid–Base Disorders. In: Fluid, Electrolyte and Acid-Base Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-25810-7_41
Download citation
DOI: https://doi.org/10.1007/978-3-031-25810-7_41
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-25809-1
Online ISBN: 978-3-031-25810-7
eBook Packages: MedicineMedicine (R0)