Abstract
Hypertension is strongly associated with increased cardiovascular events if left uncontrolled. By the end of the twentieth century, many antihypertensive medications were widely available and proven to be efficacious. However, their effects on different cardiovascular events were uncertain. Newer agents, including ACE inhibitors, calcium channel blockers (CCBs), and alpha-adrenergic blockers, had not been compared to the older agents.
ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (2002). Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA, 288(23), 2981–2997. https://doi.org/10.1001/jama.288.23.2981 .
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Rosal, N. (2023). Comparison of Medications for Hypertension (ALLHAT)-2002. In: Russell, J., Skolnik, N.S. (eds) Top Articles in Primary Care. Springer, Cham. https://doi.org/10.1007/978-3-031-25620-2_24
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DOI: https://doi.org/10.1007/978-3-031-25620-2_24
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