Skip to main content
SpringerLink
Log in

Epigenetics and Brain Plasticity: Back to Function

  • Chapter
  • First Online:
Neurobiological and Psychological Aspects of Brain Recovery

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

  • 456 Accesses

Abstract

Throughout our entire life, our brain is constantly shaped by the experience of both the outer and the inner environments. Sensory perceptions, as well as thoughts and feelings, are constantly processed and integrated in order to create a plastic representation of these environments and to efficiently adapt to perturbations; such a high demand of plasticity is met by the extraordinary capacity of our nervous system to quickly modify upon specific stimuli. Since a great number of neuronal plasticity processes rely on changes in gene induction/repression, a responsive, fine-tuned regulation of gene expression is of primary importance for a correct adaptation. Epigenetic regulation orchestrates the spatiotemporal regulation of gene expression in response to intracellular and extracellular stimuli, specifically through modifying chromatin accessibility to the transcriptional machinery, and is therefore likely to play a fundamental role in nervous system homeostasis and functioning. Despite being studied for more than forty years, our current understanding of the importance of epigenetics, particularly in highly complex fields such as neurophysiology and cognitive processes, is still very limited. This chapter aims to summarize our current knowledge on the role epigenetics plays in brain repair and how epigenome alterations may be involved in the pathophysiology of some common psychiatric disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abdouh M, et al. Bmi1 is down-regulated in the aging brain and displays antioxidant and protective activities in neurons. PLoS One. 2012;7:e31870.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Abu Hamdeh S, et al. Differential DNA methylation of the genes for amyloid precursor protein, tau, and neurofilaments in human traumatic brain injury. J Neurotrauma. 2021;38:1679–88.

    PubMed  Google Scholar 

  • Alelú-Paz R, et al. DNA methylation pattern of gene promoters of major neurotransmitter systems in older patients with Schizophrenia with severe and mild cognitive impairment. Int J Geriatr Psychiatry. 2015;30:558–65.

    PubMed  Google Scholar 

  • Alelú-Paz R, et al. Epigenetics in Schizophrenia: a pilot study of global DNA methylation in different brain regions associated with higher cognitive functions. Front Psychol. 2016;7:1496.

    PubMed  PubMed Central  Google Scholar 

  • Bach-y-Rita P. Brain plasticity as a basis for recovery of function in humans. Neuropsychologia. 1990;28:547–54.

    CAS  PubMed  Google Scholar 

  • Bailey ZS, Grinter MB, De La Torre Campos D, VandeVord PJ. Blast induced neurotrauma causes overpressure dependent changes to the DNA methylation equilibrium. Neurosci Lett. 2015;604:119–23.

    CAS  PubMed  Google Scholar 

  • Bayraktar G, et al. Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus. Neuropsychopharmacology. 2020;45:2120–30.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Beach SRH, Brody GH, Todorov AA, Gunter TD, Philibert RA. Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. Am J Med Genet Part B Neuropsychiatr Genet. 2010;153B:710–3.

    CAS  Google Scholar 

  • Blennow K, et al. Traumatic brain injuries. Nat Rev Dis Prim. 2016;2:16084.

    PubMed  Google Scholar 

  • Campbell BCV, et al. Ischaemic stroke. Nat Rev Dis Prim. 2019;5:70.

    PubMed  Google Scholar 

  • Chase KA, Gavin DP, Guidotti A, Sharma RP. Histone methylation at H3K9: evidence for a restrictive epigenome in Schizophrenia. Schizophr Res. 2013;149:15–20.

    PubMed  PubMed Central  Google Scholar 

  • Chase KA, et al. Evidence of a sex-dependent restrictive epigenome in Schizophrenia. J Psychiatr Res. 2015;65:87–94.

    PubMed  PubMed Central  Google Scholar 

  • Chen J, et al. Identification of reproducible BCL11A alterations in Schizophrenia through individual-level prediction of Coexpression. Schizophr Bull. 2020;46:1165–71.

    PubMed  PubMed Central  Google Scholar 

  • Cho Y, Cavalli V. HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration. EMBO J. 2012;31:3063–78.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cho Y, Sloutsky R, Naegle KM, Cavalli V. Injury-induced HDAC5 nuclear export is essential for axon regeneration. Cell. 2013;155:894–908.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Christian KM, Song H, Ming G. Functions and dysfunctions of adult hippocampal neurogenesis. Annu Rev Neurosci. 2014;37:243–62.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Citraro R, et al. Role of Histone Deacetylases (HDACs) in epilepsy and epileptogenesis. Curr Pharm Des. 2018;23:5546–62.

    Google Scholar 

  • Citraro R, et al. Effects of histone deacetylase inhibitors on the development of epilepsy and psychiatric comorbidity in WAG/Rij rats. Mol Neurobiol. 2020;57:408–21.

    CAS  PubMed  Google Scholar 

  • Citrome L. Schizophrenia and valproate. Psychopharmacol Bull. 2003;37(Suppl 2):74–88.

    PubMed  Google Scholar 

  • Córdova-Palomera A, et al. Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins. Transl Psychiatry. 2015;5:e557.

    PubMed  PubMed Central  Google Scholar 

  • D’Souza L, Channakkar AS, Muralidharan B. Chromatin remodelling complexes in cerebral cortex development and neurodevelopmental disorders. Neurochem Int. 2021;147:105055.

    PubMed  PubMed Central  Google Scholar 

  • Dash PK, Orsi SA, Moore AN. Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury. Neuroscience. 2009;163:1–8.

    PubMed  Google Scholar 

  • de Nijs L, et al. DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures. Clin Epigenetics. 2019;11:118.

    PubMed  PubMed Central  Google Scholar 

  • Dong E, Nelson M, Grayson DR, Costa E, Guidotti A. Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation. Proc Natl Acad Sci. 2008;105:13614–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Finelli MJ, Wong JK, Zou H. Epigenetic regulation of sensory axon regeneration after spinal cord injury. J Neurosci. 2013;33:19664–76.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Fransquet PD, Wrigglesworth J, Woods RL, Ernst ME, Ryan J. The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis. Clin Epigenetics. 2019;11:62.

    PubMed  PubMed Central  Google Scholar 

  • Freis ED. Mental depression in hypertensive patients treated for long periods with large doses of reserpine. N Engl J Med. 1954;251:1006–8.

    CAS  PubMed  Google Scholar 

  • Ganesan A, Arimondo PB, Rots MG, Jeronimo C, Berdasco M. The timeline of epigenetic drug discovery: from reality to dreams. Clin Epigenetics. 2019;11:174.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Gao W-M, et al. Immunohistochemical analysis of histone H3 acetylation and methylation—evidence for altered epigenetic signaling following traumatic brain injury in immature rats. Brain Res. 2006;1070:31–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Gilbert TM, et al. PET neuroimaging reveals histone deacetylase dysregulation in Schizophrenia. J Clin Invest. 2018;129:364–72.

    PubMed  PubMed Central  Google Scholar 

  • Grayson DR, Guidotti A. The dynamics of DNA methylation in Schizophrenia and related psychiatric disorders. Neuropsychopharmacology. 2013;38:138–66.

    CAS  PubMed  Google Scholar 

  • Gulmez Karaca K, et al. Neuronal ensemble-specific DNA methylation strengthens engram stability. Nat Commun. 2020;11:639.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Gupta S, et al. Histone methylation regulates memory formation. J Neurosci. 2010;30:3589–99.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Gupta-Agarwal S, et al. G9a/GLP histone Lysine Dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation. J Neurosci. 2012;32:5440–53.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Haghighi F, et al. Neuronal DNA methylation profiling of blast-related traumatic brain injury. J Neurotrauma. 2015;32:1200–9.

    PubMed  PubMed Central  Google Scholar 

  • Halder R, et al. DNA methylation changes in plasticity genes accompany the formation and maintenance of memory. Nat Neurosci. 2016;19:102–10.

    CAS  PubMed  Google Scholar 

  • Hilker R, et al. Heritability of Schizophrenia and Schizophrenia Spectrum based on the Nationwide Danish Twin Register. Biol Psychiatry. 2018;83:492–8.

    PubMed  Google Scholar 

  • Hirschfield RMA. The comorbidity of major depression and anxiety disorders. Prim Care Companion J Clin Psychiatry. 2001;03:244–54.

    Google Scholar 

  • Huang H-S, et al. Prefrontal dysfunction in Schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci. 2007;27:11254–62.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hutson TH, et al. Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models. Sci Transl Med. 2019;11:eaaw2064.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Januar V, Ancelin M-L, Ritchie K, Saffery R, Ryan J. BDNF promoter methylation and genetic variation in late-life depression. Transl Psychiatry. 2015;5:e619.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jawerka M, et al. The specific role of histone deacetylase 2 in adult neurogenesis. Neuron Glia Biol. 2010;6:93–107.

    PubMed  Google Scholar 

  • Jiang Y, Hsieh J. HDAC3 controls gap 2/mitosis progression in adult neural stem/progenitor cells by regulating CDK1 levels. Proc Natl Acad Sci. 2014;111:13541–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Johnston MV. Clinical disorders of brain plasticity. Brain and Development. 2004;26:73–80.

    PubMed  Google Scholar 

  • Johnstone AL, et al. EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in Schizophrenia. Neurobiol Dis. 2018;119:149–58.

    CAS  PubMed  Google Scholar 

  • Kaas GA, et al. TET1 controls CNS 5-Methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation. Neuron. 2013;79:1086–93.

    CAS  PubMed  Google Scholar 

  • Kahn RS, et al. Schizophrenia. Nat Rev Dis Prim. 2015;1:15067.

    PubMed  Google Scholar 

  • Kang H-J, et al. Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression. Prog Neuro-Psychopharmacol Biol Psychiatry. 2013;44:23–8.

    CAS  Google Scholar 

  • Kannangara TS, Vani MA. Delayed treatment with histone deacetylase inhibitors promotes stroke recovery. J Neurosci. 2017;37:12088–90.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kassis H, et al. Class IIa histone deacetylases affect neuronal remodeling and functional outcome after stroke. Neurochem Int. 2016;96:24–31.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kendler KS, Karkowski LM, Prescott CA. Fears and phobias: reliability and heritability. Psychol Med. 1999;29:539–53.

    CAS  PubMed  Google Scholar 

  • Kimura H, et al. Identification of a rare variant in CHD8 that contributes to Schizophrenia and autism spectrum disorder susceptibility. Schizophr Res. 2016;178:104–6.

    PubMed  Google Scholar 

  • Kobow K, Blümcke I. The methylation hypothesis: do epigenetic chromatin modifications play a role in epileptogenesis? Epilepsia. 2011;52:15–9.

    CAS  PubMed  Google Scholar 

  • Kobow K, et al. Deep sequencing reveals increased DNA methylation in chronic rat epilepsy. Acta Neuropathol. 2013;126:741–56.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Koga M, et al. Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in Schizophrenia. Hum Mol Genet. 2009;18:2483–94.

    CAS  PubMed  Google Scholar 

  • Lee MG, Wynder C, Schmidt DM, McCafferty DG, Shiekhattar R. Histone H3 Lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol. 2006;13:563–7.

    CAS  PubMed  Google Scholar 

  • Levenson JM, et al. Regulation of histone acetylation during memory formation in the hippocampus. J Biol Chem. 2004;279:40545–59.

    CAS  PubMed  Google Scholar 

  • Lim DA, et al. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature. 2009;458:529–33.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lin R-T, et al. LINE-1 methylation is associated with an increased risk of ischemic stroke in men. Curr Neurovasc Res. 2014;11:4–9.

    CAS  PubMed  Google Scholar 

  • Lister R, et al. Global epigenomic reconfiguration during mammalian brain development. Science (80-. ). 2013;341:1237905.

    Google Scholar 

  • Liu XS, et al. Valproic acid increases white matter repair and neurogenesis after stroke. Neuroscience. 2012;220:313–21.

    CAS  PubMed  Google Scholar 

  • Liu P, Shuaib M, Zhang H, Nadeef S, Orlando V. Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1α/β-mediated adaptive stress response pathway in skeletal muscle cells. Epigenetics Chromatin. 2019;12:78.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Liu H, et al. DNA methylation atlas of the mouse brain at single-cell resolution. Nature. 2021;598:120–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lopez JP, et al. Epigenetic regulation of BDNF expression according to antidepressant response. Mol Psychiatry. 2013;18:398–9.

    CAS  PubMed  Google Scholar 

  • Löscher W. In vivo administration of valproate reduces the nerve terminal (synaptosomal) activity of GABA aminotransferase in discrete brain areas of rats. Neurosci Lett. 1993;160:177–80.

    PubMed  Google Scholar 

  • Lu J, et al. Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury. Proc Natl Acad Sci. 2013;110:10747–52.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Maag JLV, et al. Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo. BMC Genomics. 2017;18:250.

    PubMed  PubMed Central  Google Scholar 

  • Machnes ZM, et al. DNA methylation mediates persistent Epileptiform activity in vitro and in vivo. PLoS One. 2013;8:e76299.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Malenka RC, Bear MF. LTP and LTD. Neuron. 2004;44:5–21.

    CAS  PubMed  Google Scholar 

  • McCarthy SE, et al. De novo mutations in Schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability. Mol Psychiatry. 2014;19:652–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Miller CA, Sweatt JD. Covalent modification of DNA regulates memory formation. Neuron. 2007;53:857–69.

    CAS  PubMed  Google Scholar 

  • Miller CA, et al. Cortical DNA methylation maintains remote memory. Nat Neurosci. 2010;13:664–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Molendijk ML, et al. Serum levels of brain-derived neurotrophic factor in major depressive disorder: state–trait issues, clinical features and pharmacological treatment. Mol Psychiatry. 2011;16:1088–95.

    CAS  PubMed  Google Scholar 

  • Molofsky AV, et al. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature. 2003;425:962–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Morris-Blanco KC, et al. Induction of DNA hydroxymethylation protects the brain after stroke. Stroke. 2019;50:2513–21.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Muñoz P, et al. Inhibition of DNA methylation impairs synaptic plasticity during an early time window in rats. Neural Plast. 2016;2016:1–13.

    Google Scholar 

  • Nuss P. Anxiety disorders and GABA neurotransmission: a disturbance of modulation. Neuropsychiatr Dis Treat. 2015;11:165–75.

    PubMed  PubMed Central  Google Scholar 

  • Palomer E, Carretero J, Benvegnù S, Dotti CG, Martin MG. Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons. Nat Commun. 2016;7:11081.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Peedicayil J. The potential role of epigenetic drugs in the treatment of anxiety disorders. Neuropsychiatr Dis Treat. 2020;16:597–606.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Phiel CJ, et al. Histone deacetylase is a direct target of Valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001;276:36734–41.

    CAS  PubMed  Google Scholar 

  • Reddy SD, Clossen BL, Reddy DS. Epigenetic histone Deacetylation inhibition prevents the development and persistence of temporal lobe epilepsy. J Pharmacol Exp Ther. 2018;364:97–109.

    CAS  PubMed  Google Scholar 

  • Ryley Parrish R, et al. Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus. Neuroscience. 2013;248:602–619.

    Google Scholar 

  • Sada N, et al. Inhibition of HDAC increases BDNF expression and promotes neuronal rewiring and functional recovery after brain injury. Cell Death Dis. 2020;11:655.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Schroeder FA, et al. Expression of HDAC2 but not HDAC1 transcript is reduced in dorsolateral prefrontal cortex of patients with Schizophrenia. ACS Chem Neurosci. 2017;8:662–8.

    CAS  PubMed  Google Scholar 

  • Shein NA, et al. Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury. FASEB J. 2009;23:4266–75.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Shi M, et al. Methylation status of the serotonin transporter promoter CpG Island is associated with major depressive disorder in Chinese Han population. J Nerv Ment Dis. 2017;205:641–6.

    PubMed  Google Scholar 

  • Sophie Su Y, Veeravagu A, Grant G. Neuroplasticity after traumatic brain injury. In: Translational research in traumatic brain injury. CRC Press; 2016. Chapter 8.

    Google Scholar 

  • Stapels M, et al. Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance. Sci Signal. 2010;3:ra15.

    PubMed  Google Scholar 

  • Su F, Xu W. Enhancing brain plasticity to promote stroke recovery. Front Neurol. 2020;11:1–15.

    Google Scholar 

  • Sun H, et al. ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior. Nat Med. 2015;21:1146–53.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Suri D, Bhattacharya A, Vaidya VA. Early stress evokes temporally distinct consequences on the hippocampal transcriptome, anxiety and cognitive behaviour. Int J Neuropsychopharmacol. 2014;17:289–301.

    CAS  PubMed  Google Scholar 

  • Tang B, Dean B, Thomas EA. Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders. Transl Psychiatry. 2011;1:e64.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tang Y, et al. Inhibiting histone deacetylase 2 (HDAC2) promotes functional recovery from stroke. J Am Heart Assoc. 2017;6:892–901.

    Google Scholar 

  • Treble-Barna A, et al. Epigenetic effects on pediatric traumatic brain injury recovery (EETR): an observational, prospective, longitudinal concurrent Cohort Study protocol. Front Neurol. 2020;11:1–14.

    Google Scholar 

  • Tsankova NM. Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J Neurosci. 2004;24:5603–10.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tsankova NM, et al. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci. 2006;9:519–25.

    CAS  PubMed  Google Scholar 

  • Tseng P-T, et al. Significant effect of valproate augmentation therapy in patients with Schizophrenia. Medicine (Baltimore). 2016;95:e2475.

    CAS  PubMed  Google Scholar 

  • Vecsey CG, et al. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB: CBP-dependent transcriptional activation. J Neurosci. 2007;27:6128–40.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Vogel-Ciernia A, Wood MA. Neuron-specific chromatin remodeling: a missing link in epigenetic mechanisms underlying synaptic plasticity, memory, and intellectual disability disorders. Neuropharmacology. 2014;80:18–27.

    CAS  PubMed  Google Scholar 

  • Vogel-Ciernia A, et al. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci. 2013;16:552–61.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wang Y, et al. Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury. J Neurotrauma. 2011;28:259–68.

    PubMed  PubMed Central  Google Scholar 

  • Wang G, et al. Scriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway. Neurotherapeutics. 2013;10:124–42.

    PubMed  Google Scholar 

  • Wang D, et al. Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice. Acta Pharmacol Sin. 2018;39:866–74.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Webb LM, Phillips KE, Ho MC, Veldic M, Blacker CJ. The relationship between DNA methylation and antidepressant medications: a systematic review. Int J Mol Sci. 2020;21:826.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Weïwer M, Lewis MC, Wagner FF, Holson EB. Therapeutic potential of isoform selective HDAC inhibitors for the treatment of Schizophrenia. Future Med Chem. 2013;5:1491–508.

    PubMed  Google Scholar 

  • Wiegand A, et al. DNA methylation differences associated with social anxiety disorder and early life adversity. Transl Psychiatry. 2021;11:104.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Williams-Karnesky RL, et al. Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J Clin Invest. 2013;123:3552–63.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wu H, et al. Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science (80- ). 2010;329:444–8.

    CAS  Google Scholar 

  • Zeng M, et al. The role of DNA methylation in ischemic stroke: a systematic review. Front Neurol. 2020;11:566124.

    PubMed  PubMed Central  Google Scholar 

  • Zhang R-R, et al. Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell. 2013;13:237–45.

    PubMed  PubMed Central  Google Scholar 

  • Zhang J, et al. Ezh2 regulates adult hippocampal neurogenesis and memory. J Neurosci. 2014;34:5184–99.

    PubMed  PubMed Central  Google Scholar 

  • Zhang Z, et al. Epigenomic diversity of cortical projection neurons in the mouse brain. Nature. 2021;598:167–73.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zhou R, Chen F, Chang F, Bai Y, Chen L. Persistent overexpression of DNA methyltransferase 1 attenuating GABAergic inhibition in basolateral amygdala accounts for anxiety in rat offspring exposed perinatally to low-dose bisphenol A. J Psychiatr Res. 2013;47:1535–44.

    PubMed  Google Scholar 

  • Zhu Q, et al. Increased expression of DNA methyltransferase 1 and 3a in human temporal lobe epilepsy. J Mol Neurosci. 2012;46:420–6.

    CAS  PubMed  Google Scholar 

  • Zhu C, et al. Involvement of epigenetic modifications of GABAergic interneurons in Basolateral Amygdala in anxiety-like phenotype of prenatally stressed mice. Int J Neuropsychopharmacol. 2018;21:570–81.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zocher S, et al. De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis. EMBO J. 2021;40:e107100.

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. King Abdullah University of Science & Technology (KAUST), BESE Division, Thuwal, Saudi Arabia

    Gabriele Morelli, Francesco Della Valle & Valerio Orlando

Authors
  1. Gabriele Morelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francesco Della Valle
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Valerio Orlando
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Valerio Orlando .

Editor information

Editors and Affiliations

  1. Santa Lucia Foundation IRCCS, Rome, Italy

    Laura Petrosini

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Morelli, G., Della Valle, F., Orlando, V. (2023). Epigenetics and Brain Plasticity: Back to Function. In: Petrosini, L. (eds) Neurobiological and Psychological Aspects of Brain Recovery. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-031-24930-3_11

Download citation

Publish with us

Policies and ethics

Search

Navigation