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Donor Site Options

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Cleft Maxillary Reconstruction

Abstract

Maxillary cleft bone grafting has been predictably performed with a demonstrable outcome benefit to the patient for decades [1–3]. Upon bone grafting’s resurgence in the 1970s, the graft source that was utilized was the anterior iliac crest. Since that time, it has largely been held as the gold standard, despite numerous comparative studies between it, and other anatomic sites and materials. Now, however, we are in an era where the interest in tissue engineering has peaked and most new efforts to improve grafting success involve alloplasts rather than new or different anatomic sites to obtain bone. That said, few alloplastic or tissue engineering solutions have achieved the outcomes of autogenous bone, specifically as the outcomes pertain to the grafted or recipient site. Where alternate, alloplastic, or allogenic solutions have excelled, is the dramatic decrease in or elimination of donor site morbidity and operative time. Ultimately, the decision of where to obtain your graft is patient and situation dependent, with each case presenting unique nuances and justification for a given technique. It is best to have a good understanding of the options and the evidence in order to make the best decision for and along with your patient.

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References

  1. Boyne PJ, Sands NR. Secondary bone grafting of residual alveolar defects. J Oral Surg. 1972;30(2):87–92.

    CAS  PubMed  Google Scholar 

  2. Boyne PJ, Sands NR. Combined orthodontic-surgical management of residual palato-alveolar cleft defects. Am J Orthod. 1976;70(1):20–37.

    CAS  PubMed  Google Scholar 

  3. Bergland O, Semb G, Abyholm FE. Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orthodontic treatment. Cleft Palate J. 1986;23(3):175–205.

    CAS  PubMed  Google Scholar 

  4. Maus U, Andereya S, Gravius S, Siebert CH, Schippmann T, Ohnsorge JA, Niedhart C. How to store autologous bone graft perioperatively: an in vitro study. Arch Orthop Trauma Surg. 2008;128(9):1007–11.

    PubMed  Google Scholar 

  5. Laursen M, Christensen FB, Bünger C, Lind M. Optimal handling of fresh cancellous bone graft: different peroperative storing techniques evaluated by in vitro osteoblast-like cell metabolism. Acta Orthop Scand. 2003;74(4):490–6.

    PubMed  Google Scholar 

  6. Hassanein AH, Greene AK, Arany PR, Padwa BL. Intraoperative cooling of iliac bone graft: an experimental evaluation of cell viability. J Oral Maxillofac Surg. 2012;70(7):1633–5.

    PubMed  Google Scholar 

  7. Doucet JC, Russell K, Kearns J, Martyna S, Daskalogiannakis J, Glick P, Beals S, Kornbluth M, Mercado A, Sitzman T, Emanuele N, Campbell RE, Hathaway RR, Long R Jr. Comparison of alveolar bone graft outcomes with or without the use of cortical bone graft for nasal floor reconstruction in cleft lip and palate [abstract]. In: American cleft palate and craniofacial association 74th annual meeting. Colorado Springs, CO; 2017 March. p. 13–8. Abstract 237.

    Google Scholar 

  8. Hellquist R, Skoog T. The influence of primary periosteoplasty on maxillary growth and deciduous occlusion in cases of complete unilateral cleft lip and palate. A longitudinal study from infancy to the age of 5. Scand J Plast Reconstr Surg. 1976;10(3):197–208.

    CAS  PubMed  Google Scholar 

  9. Millard DR, Latham R, Huifen X, Spiro S, Morovic C. Cleft lip and palate treated by presurgical orthopedics, gingivoperiosteoplasty, and lip adhesion (POPLA) compared with previous lip adhesion method: a preliminary study of serial dental casts. Plast Reconstr Surg. 1999;103(6):1630–44.

    CAS  PubMed  Google Scholar 

  10. Wood RJ, Grayson BH, Cutting CB. Gingivoperiosteoplasty and midfacial growth. Cleft Palate Craniofac J. 1997;34(1):17–20.

    CAS  PubMed  Google Scholar 

  11. Skoog T. The use of periosteal flaps in the repair of clefts of the primary palate. Cleft Palate J. 1965:2. 1e1.

    Google Scholar 

  12. Wang YC, Liao YF, Chen PK. Outcome of gingivoperiosteoplasty for the treatment of alveolar clefts in patients with unilateral cleft lip and palate. Br J Oral Maxillofac Surg. 2013;51(7):650–5.

    PubMed  Google Scholar 

  13. Matic DB, Power SM. Evaluating the success of gingivoperiosteoplasty versus secondary bone grafting in patients with unilateral clefts. Plast Reconstr Surg. 2008;121(4):1343–53.

    CAS  PubMed  Google Scholar 

  14. Matic DB, Power SM. The effects of gingivoperiosteoplasty following alveolar molding with a pin-retained Latham appliance versus secondary bone grafting on midfacial growth in patients with unilateral clefts. Plast Reconstr Surg. 2008;122(3):863–70.

    CAS  PubMed  Google Scholar 

  15. Power SM, Matic DB. Gingivoperiosteoplasty following alveolar molding with a Latham appliance versus secondary bone grafting: the effects on bone production and midfacial growth in patients with bilateral clefts. Plast Reconstr Surg. 2009 Aug;124(2):573–82.

    CAS  PubMed  Google Scholar 

  16. Berkowitz S, Mejia M, Bystrik A. A comparison of the effects of the Latham-Millard procedure with those of a conservative treatment approach for dental occlusion and facial aesthetics in unilateral and bilateral complete cleft lip and palate: part I. dental occlusion. Plast Reconstr Surg. 2004;113(1):1–18.

    PubMed  Google Scholar 

  17. Hsieh CH, Ko EW, Chen PK, Huang CS. The effect of gingivoperiosteoplasty on facial growth in patients with complete unilateral cleft lip and palate. Cleft Palate Craniofac J. 2010 Sep;47(5):439–46.

    PubMed  Google Scholar 

  18. Sato Y, Grayson BH, Garfinkle JS, Barillas I, Maki K, Cutting CB. Success rate of gingivoperiosteoplasty with and without secondary bone grafts compared with secondary alveolar bone grafts alone. Plast Reconstr Surg. 2008;121(4):1356–67.

    CAS  PubMed  Google Scholar 

  19. Meazzini MC, Rossetti G, Garattini G, Semb G, Brusati R. Early secondary gingivo-alveolo-plasty in the treatment of unilateral cleft lip and palate patients: 20 years experience. J Craniomaxillofac Surg. 2010 Apr;38(3):185–91.

    PubMed  Google Scholar 

  20. Freihofer HP, Borstlap WA, Kuijpers-Jagtman AM, Voorsmit RA, van Damme PA, Heidbüchel KL, Borstlap-Engels VM. Timing and transplant materials for closure of alveolar clefts. A clinical comparison of 296 cases. J Craniomaxillofac Surg. 1993;21(4):143–8.

    CAS  PubMed  Google Scholar 

  21. Eppley BL, Sadove AM. Management of alveolar cleft bone grafting--state of the art. Cleft Palate Craniofac J 2000 May;37(3):229–233.

    Google Scholar 

  22. Eppley BL. Donor site morbidity of rib graft harvesting in primary alveolar cleft bone grafting. J Craniofac Surg. 2005;16(2):335–8.

    PubMed  Google Scholar 

  23. Whitaker LA, Munro IR, Salyer KE, Jackson IT, Ortiz-Monasterio F, Marchac D. Combined report of problems and complications in 793 craniofacial operations. Plast Reconstr Surg. 1979;64(2):198–203.

    CAS  PubMed  Google Scholar 

  24. Laurie SW, Kaban LB, Mulliken JB, Murray JE. Donor-site morbidity after harvesting rib and iliac bone. Plast Reconstr Surg. 1984;73(6):933–8.

    CAS  PubMed  Google Scholar 

  25. Ohara K, Nakamura K, Ohta E. Chest wall deformities and thoracic scoliosis after costal cartilage graft harvesting. Plast Reconstr Surg. 1997;99(4):1030–6.

    CAS  PubMed  Google Scholar 

  26. Zins JE, Whitaker LA. Membranous versus endochondral bone: implications for craniofacial reconstruction. Plast Reconstr Surg. 1983;72(6):778–85.

    CAS  PubMed  Google Scholar 

  27. Kusiak JF, Zins JE, Whitaker LA. The early revascularization of membranous bone. Plast Reconstr Surg. 1985;76(4):510–6.

    CAS  PubMed  Google Scholar 

  28. Rabie AB, Chow KM, Wong RW. Demineralized intramembranous bone matrix augments the healing of endochondral bone graft. Int J Adult Orthodon Orthognath Surg. 1999;14(3):185–97.

    CAS  PubMed  Google Scholar 

  29. Cohen M, Figueroa AA, Haviv Y, Schafer ME, Aduss H. Iliac versus cranial bone for secondary grafting of residual alveolar clefts. Plast Reconstr Surg. 1991;87(3):423–7.

    CAS  PubMed  Google Scholar 

  30. Wolfe SA. Iliac or cranial bone for secondary grafting of residual alveolar clefts. Plast Reconstr Surg. 1991;88(5):924.

    CAS  PubMed  Google Scholar 

  31. LaRossa D, Buchman S, Rothkopf DM, Mayro R, Randall P. A comparison of iliac and cranial bone in secondary grafting of alveolar clefts. Plast Reconstr Surg. 1995;96(4):789–97.

    CAS  PubMed  Google Scholar 

  32. Harsha BC, Turvey TA, Powers SK. Use of autogenous cranial bone grafts in maxillofacial surgery: a preliminary report. J Oral Maxillofac Surg. 1986;44(1):11–5.

    CAS  PubMed  Google Scholar 

  33. Sindet-Pedersen S, Enemark H. Mandibular bone grafts for reconstruction of alveolar clefts. J Oral Maxillofac Surg. 1988;46(7):533–7.

    CAS  PubMed  Google Scholar 

  34. Enemark H, Jensen J, Bosch C. Mandibular bone graft material for reconstruction of alveolar cleft defects: long-term results. Cleft Palate Craniofac J. 2001;38(2):155–63.

    CAS  PubMed  Google Scholar 

  35. Witsenburg B, Remmelink HJ. Reconstruction of residual alveolo-palatal bone defects in cleft patients. A retrospective study. J Craniomaxillofac Surg. 1993;21(6):239–44.

    CAS  PubMed  Google Scholar 

  36. Ilankovan V, Stronczek M, Telfer M, Peterson LJ, Stassen LF, Ward-Booth P. A prospective study of trephined bone grafts of the tibial shaft and iliac crest. Br J Oral Maxillofac Surg. 1998;36(6):434–9.

    CAS  PubMed  Google Scholar 

  37. Dickinson BP, Ashley RK, Wasson KL, O’Hara C, Gabbay J, Heller JB, Bradley JP. Reduced morbidity and improved healing with bone morphogenic protein-2 in older patients with alveolar cleft defects. Plast Reconstr Surg. 2008 Jan;121(1):209–17.

    CAS  PubMed  Google Scholar 

  38. Francis CS, Mobin SS, Lypka MA, Rommer E, Yen S, Urata MM, Hammoudeh JA. rhBMP-2 with a demineralized bone matrix scaffold versus autologous iliac crest bone graft for alveolar cleft reconstruction. Plast Reconstr Surg. 2013;131(5):1107–15.

    CAS  PubMed  Google Scholar 

  39. Hammoudeh JA, Fahradyan A, Gould DD, Liang F, Imahiyerobo T, Urbinelli L, Nguyen JT, Magee W 3rd, Yen S, Urata MM. A comparative analysis of rhBMP-2/DBM vs. ICBG for secondary alveolar bone grafts in patients with cleft lip and palate: review of 501 cases. Plast Reconstr Surg. 2017;

    Google Scholar 

  40. Liang F, Yen S, Imahiyerobo T, Sanborn L, Yen L, Yen D, Nazarian S, Jedrzejewski B, Urata M, Hammoudeh J. 3D cone beam computed tomography volumetric outcomes of rhBMP-2/demineralized bone matrix vs iliac crest bone graft for alveolar cleft reconstruction. Plast Reconstr Surg. 2017;

    Google Scholar 

  41. Herford AS, Boyne PJ, Rawson R, Williams RP. Bone morphogenetic protein-induced repair of the premaxillary cleft. J Oral Maxillofac Surg. 2007;65(11):2136–41.

    PubMed  Google Scholar 

  42. Santiago PE, Grayson BH, Cutting CB, Gianoutsos MP, Brecht LE, Kwon SM. Reduced need for alveolar bone grafting by presurgical orthopedics and primary gingivoperiosteoplasty. Cleft Palate Craniofac J. 1998;35(1):77–80.

    CAS  PubMed  Google Scholar 

  43. Sivarajasingam V, Pell G, Morse M, Shepherd JP. Secondary bone grafting of alveolar clefts: a densitometric comparison of iliac crest and tibial bone grafts. Cleft Palate Craniofac J. 2001 Jan;38(1):11–4.

    CAS  PubMed  Google Scholar 

  44. Kortebein MJ, Nelson CL, Sadove AM. Retrospective analysis of 135 secondary alveolar cleft grafts using iliac or calvarial bone. J Oral Maxillofac Surg. 1991;49(5):493–8.

    CAS  PubMed  Google Scholar 

  45. Sadove AM, Nelson CL, Eppley BL, Nguyen B. An evaluation of calvarial and iliac donor sites in alveolar cleft grafting. Cleft Palate J. 1990;27(3):225–8.

    CAS  PubMed  Google Scholar 

  46. Rudman RA. Prospective evaluation of morbidity associated with iliac crest harvest for alveolar cleft grafting. J Oral Maxillofac Surg. 1997 Mar;55(3):219–23.

    CAS  PubMed  Google Scholar 

  47. Hughes CW, Revington PJ. The proximal tibia donor site in cleft alveolar bone grafting: experience of 75 consecutive cases. J Craniomaxillofac Surg. 2002;30(1):12–6.

    PubMed  Google Scholar 

  48. Moussa NT, Dym H. Maxillofacial bone grafting materials. Dent Clin North Am. 2020;64(2):473–90. https://doi.org/10.1016/j.cden.2019.12.011. Epub 2020 Feb 1

    Article  PubMed  Google Scholar 

  49. Maxon BB, Baxter SD, Vig KW, Fonseca RJ. Allogeneic bone for secondary alveolar cleft osteoplasty. J Oral Maxillofac Surg. 1990;48(9):933–41.

    Google Scholar 

  50. Thuaksuban N, Nuntanaranont T, Pripatnanont P. A comparison of autogenous bone graft combined with deproteinized bovine bone and autogenous bone graft alone for treatment of alveolar cleft. Int J Oral Maxillofac Surg. 2010;39(12):1175–80.

    CAS  PubMed  Google Scholar 

  51. van Hout WM, Mink van der Molen AB, Breugem CC, Koole R, Van Cann EM. Reconstruction of the alveolar cleft: can growth factor-aided tissue engineering replace autologous bone grafting? A literature review and systematic review of results obtained with bone morphogenetic protein-2. Clin Oral Investig. 2011;15(3):297–303.

    PubMed  PubMed Central  Google Scholar 

  52. Neovius E, Lemberger M, Docherty Skogh AC, Hilborn J, Engstrand T. Alveolar bone healing accompanied by severe swelling in cleft children treated with bone morphogenetic protein-2 delivered by hydrogel. J Plast Reconstr Aesthet Surg. 2013;66(1):37–42.

    CAS  PubMed  Google Scholar 

  53. Canan LW Jr, da Silva Freitas R, Alonso N, Tanikawa DY, Rocha DL, Coelho JC, Canan LW Jr, da Silva Freitas R, Alonso N, Tanikawa DY, Rocha DL, Coelho JC. Human bone morphogenetic protein-2 use for maxillary reconstruction in cleft lip and palate patients. J Craniofac Surg. 2012;23(6):1627–33.

    PubMed  Google Scholar 

  54. Goss JA, Hunter MS, Armbrecht ES, Lin AY. Higher dosages of BMP-2 in alveolar cleft repair result in higher rates of postoperative nasal stenosis. Plast Reconstr Surg. 2015;136(4 Suppl):4.

    Google Scholar 

  55. Singh A, Morris RJ. The yin and Yang of bone morphogenetic proteins in cancer. Cytokine Growth Factor Rev. 2010;21(4):299–313.

    CAS  PubMed  PubMed Central  Google Scholar 

  56. Sayama C, Willsey M, Chintagumpala M, Brayton A, Briceño V, Ryan SL, Luerssen TG, Hwang SW, Jea A. Routine use of recombinant human bone morphogenetic protein-2 in posterior fusions of the pediatric spine and incidence of cancer. J Neurosurg Pediatr. 2015;16(1):4–13.

    PubMed  Google Scholar 

  57. Kelly MP, Savage JW, Bentzen SM, Hsu WK, Ellison SA, Anderson PA. Cancer risk from bone morphogenetic protein exposure in spinal arthrodesis. J Bone Joint Surg Am. 2014;96(17):1417–22.

    PubMed  PubMed Central  Google Scholar 

  58. Carragee EJ, Chu G, Rohatgi R, Hurwitz EL, Weiner BK, Yoon ST, Comer G, Kopjar B. Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis. J Bone Joint Surg Am. 2013;95(17):1537–45.

    PubMed  Google Scholar 

  59. Macisaac ZM, Rottgers SA, Davit AJ 3rd, Ford M, Losee JE, Kumar AR. Alveolar reconstruction in cleft patients: decreased morbidity and improved outcomes with supplemental demineralized bone matrix and cancellous allograft. Plast Reconstr Surg. 2012;130(3):625–32.

    CAS  PubMed  Google Scholar 

  60. Melville JC, Tursun R, Green JM 3rd, Marx RE. Reconstruction of a post-traumatic maxillary ridge using a radial forearm free flap and immediate tissue engineering (bone morphogenetic protein, bone marrow aspirate concentrate, and cortical-cancellous bone): case report. J Oral Maxillofac Surg. 2017;75(2):438.e1–6.

    PubMed  Google Scholar 

  61. Shawky H, Seifeldin SA. Does platelet-rich fibrin enhance bone quality and quantity of alveolar cleft reconstruction? Cleft Palate Craniofac J. 2016;53(5):597–606.

    PubMed  Google Scholar 

  62. Bajestan MN, Rajan A, Edwards SP, Aronovich S, Cevidanes LHS, Polymeri A, Travan S, Kaigler D. Stem cell therapy for reconstruction of alveolar cleft and trauma defects in adults: a randomized controlled, clinical trial. Clin Implant Dent Relat Res. 2017;

    Google Scholar 

  63. Moreau JL, Caccamese JF, Coletti DP, Sauk JJ, Fisher JP. Tissue engineering solutions for cleft palates. J Oral Maxillofac Surg. 2007;65(12):2503–11.

    PubMed  Google Scholar 

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Caccamese, J.F. (2023). Donor Site Options. In: Ricalde, P. (eds) Cleft Maxillary Reconstruction. Springer, Cham. https://doi.org/10.1007/978-3-031-24636-4_5

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  • DOI: https://doi.org/10.1007/978-3-031-24636-4_5

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