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An Overview of Lipid Metabolism

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Pediatric Dyslipidemia

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Abstract

In this chapter, we provide a brief overview of lipid metabolism with a focused discussion and review of lipoproteins, endogenous and exogenous lipid metabolism, and HDL metabolism and reverse cholesterol transport. This chapter focus on key steps in the lipid and lipoprotein metabolism that are targeted for pharmacotherapy.

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References

  1. Altmann SW, et al. Niemann-pick C1 like 1 protein is critical for intestinal cholesterol absorption. Science. 2004;303(5661):1201–4.

    Article  CAS  PubMed  Google Scholar 

  2. Yu L, et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest. 2002;110(5):671–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Chang TY, et al. Acyl-coenzyme a: cholesterol acyltransferases. Am J Physiol Endocrinol Metab. 2009;297(1):E1–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Shepherd J. The role of the exogenous pathway in hypercholesterolaemia. Eur Heart J Suppl. 2001;3(suppl_E):E2–5.

    Article  CAS  Google Scholar 

  5. Feingold KR, Grunfeld C. Introduction to lipids and lipoproteins. In: Endotext. South Dartmouth (MA): MDText.com, Inc., 2015.

    Google Scholar 

  6. Tall A. An overview of reverse cholesterol transport. Eur Heart J. 1998;19:A31–5.

    CAS  PubMed  Google Scholar 

  7. McGill HC Jr, McMahan CA. Determinants of atherosclerosis in the young. Pathobiological determinants of atherosclerosis in youth (PDAY) research group. Am J Cardiol. 1998;82(10):30T–6T.

    Article  PubMed  Google Scholar 

  8. Berenson GS, et al. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. N Engl J Med. 1998;338(23):1650–6.

    Article  CAS  PubMed  Google Scholar 

  9. Steinbrecher UP, Zhang H, Lougheed M. Role of oxidatively modified LDL in atherosclerosis. Free Radic Biol Med. 1990;9(2):155–68.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatric Endocrinology, Mary Bridge Children’s Hospital, Tacoma, WA, USA

    Bhuvana Sunil

  2. Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA

    Ambika Ashraf

Authors
  1. Bhuvana Sunil
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  2. Ambika Ashraf
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Editor information

Editors and Affiliations

  1. Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA

    Ambika Ashraf

  2. Department of Pediatrics, Mary Bridge Children’s Hospital, Tacoma, WA, USA

    Bhuvana Sunil

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© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Sunil, B., Ashraf, A. (2023). An Overview of Lipid Metabolism. In: Ashraf, A., Sunil, B. (eds) Pediatric Dyslipidemia. Springer, Cham. https://doi.org/10.1007/978-3-031-24113-0_2

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  • DOI: https://doi.org/10.1007/978-3-031-24113-0_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-24112-3

  • Online ISBN: 978-3-031-24113-0

  • eBook Packages: MedicineMedicine (R0)

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