Abstract
The renin angiotensin-system, its well-known systemic regulation of the systemic pressure and its role in hypertension has been widely studies, but this system has also a paracrine function. The RAS was been found to be express in almost every tissue, and there is enough evidence to link it to carcinogenesis and cancer progression. With the purpose of facilitating advances in the study of this disease, Weinberg and Hanahan described a series of cellular characteristics that tumor cells can share, which are known as the Hallmarks of cancer. These are defined as “the distinctive and complementary capacities that cells must acquire during the carcinogenesis process that allow them to survive, proliferate and disseminate”. Originally there were 6, but currently up to 10 are “officially” accepted and 4 new ones were proposed by Hanahan in early 2022. In this chapter we describe how RAS is related to the 10 classical hallmarks of cancer, defined as a series of cellular characteristics that tumor cells can share, but also to the 4 new hallmarks described recently.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70
Hanahan D (2022) Hallmarks of cancer: new dimensions. Cancer Discovery. American Association for Cancer Research Inc., vol 12, p 31–46
Perdomo-Pantoja A, Mejía-Pérez SI, Reynoso-Noverón N, Gómez-Flores-Ramos L, Soto-Reyes E, Sánchez-Correa TE, et al (2018) Angiotensinogen rs5050 germline genetic variant as potential biomarker of poor prognosis in astrocytoma. PLoS One 13(11)
Perdomo-Pantoja A, Mejía-Pérez SI, Gómez-Flores-Ramos L, Lara-Velazquez M, Orillac C, Gómez-Amador JL, et al (2018) Renin angiotensin system and its role in biomarkers and treatment in gliomas. J Neurooncol 138(1)
Wegman-Ostrosky T, Soto-Reyes E, Vidal-Millán S, Sánchez-Corona J (2015) The renin-angiotensin system meets the hallmarks of cancer. JRAAS—J Renin-Angiotensin-Aldosterone Syst. SAGE Publications Ltd; p. 227–233
Afsar B, Afsar RE, Ertuglu LA, Kuwabara M, Ortiz A, Covic A, et al. Renin-angiotensin system and cancer: epidemiology, cell signaling, genetics and epigenetics. Vol. 23, Clinical and Translational Oncology. Springer Science and Business Media Deutschland GmbH; 2021. p. 682–96.
Santos RAS, Sampaio WO, Alzamora AC, Motta-Santos D, Alenina N, Bader M, et al (2018) The ACE2/angiotensin-(1–7)/mas axis of the renin-angiotensin system: focus on angiotensin-(1–7). Physiological Reviews. American Physiological Society 98:505–53.
Jaworska K, Koper M, Ufnal M (2021) Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels. Am J Physiol—Gastrointestinal Liver Physiol. Am Physiol Soc 321:G355–66
Medina-Enríquez MM, Lopez-León S, Carlos-Escalante JA, Aponte-Torres Z, Cuapio A, Wegman-Ostrosky T (2020) ACE2: the molecular doorway to SARS-CoV-2. Cell Biosci [Internet]. [cited 2022 May 31];10(1):148. Available from: http://www.ncbi.nlm.nih.gov/pubmed/33380340
Martin JH, Mohammed R, Delforce SJ, Skerrett-Byrne DA, de Meaultsart CC, Almazi JG et al (2022) Role of the prorenin receptor in endometrial cancer cell growth. Oncotarget 13(1):587–599
Pinter M, Jain RK (2017) Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy. Sci Transl Med. Am Assoc Adv Sci 9
Arrieta O, Pineda-Olvera B, Guevara-Salazar P, Hernández-Pedro N, Morales-Espinosa D, Cerón-Lizarraga TL et al (2008) Expression of AT1 and AT2 angiotensin receptors in astrocytomas is associated with poor prognosis. Br J Cancer 99(1):160–166
AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U (2001) The angiotensin II AT2 receptor is an AT1Receptor antagonist. J Biol Chem [Internet]. [cited 2022 Jun 7] 276(43):39721–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0021925820600345
Epelman S, Shrestha K, Troughton RW, Francis GS, Sen S, Klein AL et al (2009) Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes. J Card Fail 15(7):565–571
George AJ, Thomas WG, Hannan RD. The renin–angiotensin system and cancer: old dog, new tricks. Nat Rev Cancer [Internet]. 2010 Nov 22 [cited 2022 Jun 7] 10(11):745–59. Available from: http://www.nature.com/articles/nrc2945
Petrashova DA, Kolomeichuk SN (2021) Пoлимopфный вapиaнт in/del гeнa aнгиoтeнзинпpeвpaщaющeгo фepмeнтa (AПФ) и дecтaбилизaция гeнoмa y дeтeй, пpoживaющиx нa Кpaйнeм Ceвepe. Klin Lab Diagn 66(10):635–640
Carlos-Escalante JA, de Jesús-Sánchez M, Rivas-Castro A, Pichardo-Rojas PS, Arce C, egman-Ostrosky T. The Use of Antihypertensive Drugs as Coadjuvant Therapy in Cancer. Front Oncol [Internet]. 2021 [cited 2022 May 31];11:660943. Available from: http://www.ncbi.nlm.nih.gov/pubmed/34094953
Barton M (2014) Aging and endothelin: Determinants of disease. Life Sciences, vol 118. Elsevier Inc, pp 97–109
Wegman-Ostrosky T, Savage SA (2017) The genomics of inherited bone marrow failure: from mechanism to the clinic. British J Haematol. Blackwell Publishing Ltd, 177:526–42
Vasan RS, Demissie S, Kimura M, Cupples LA, Rifai N, White C et al (2008) Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham heart study. Circulation 117(9):1138–1144
Camci L, Kilic Z, Dinleyici EC, Muslumanoglu H, Tepeli E, Ucar B (2009) Angiotensin-converting enzyme gene insertion/deletion polymorphism frequency in normotensive children with a positive family history of essential hypertension. J Paediatr Child Health 45(12):742–746
Liberti M V., Locasale JW (2016) The Warburg effect: how does it benefit cancer cells? Trends in Biochemical Sciences. Elsevier Ltd 41:211–8.
Aging and endothelin: Determinants of disease | Elsevier Enhanced Reader [Internet]. [cited 2022 Jun 1]. Available from: https://reader.elsevier.com/reader/sd/pii/S0024320514007589?token=3B96677A080586E193BB45D78C379E79EC18A1099C9E649208333C7C3AE29490D987F8058800ED54DAF90C08F4F88088&originRegion=us-east-1&originCreation=20220602024331
Santos-Otte P, Leysen H, van Gastel J, Hendrickx JO, Martin B, Maudsley S. G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence. Comput Struct Biotechnol J [Internet]. 2019 Jan 1 [cited 2022 Jun 7];17:1265–77. Available from: http://www.ncbi.nlm.nih.gov/pubmed/31921393
Broeker KAE, Schrankl J, Fuchs MAA, Kurtz A (2022) Flexible and multifaceted: the plasticity of renin-expressing cells. Pflugers Arch [Internet]. [cited 2022 Jun 7]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/35511367
Tain Y-L, Hsu C-N (2022) Hypertension of developmental origins: consideration of gut microbiome in animal models. Biomedicines [Internet]. [cited 2022 May 31] 10(4):875. Available from: http://www.ncbi.nlm.nih.gov/pubmed/35453625
Hernández-Romero IA, Guerra-Calderas L, Salgado-Albarrán M, Maldonado-Huerta T, Soto-Reyes E (2019) The regulatory roles of non-coding rnas in angiogenesis and neovascularization from an epigenetic perspective. Front Oncol 9(OCT)
Luan Z, Liu B, Shi L (2019) Angiotensin II-induced micro RNA-21 culprit for non-small-cell lung adenocarcinoma. Drug Dev Res 80(8):1031–1039
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Daza-Galicia, K., Augusto Landetta-Platonoff, J., Wegman-Ostrosky, T. (2023). The New Dimension of the Renin-Angiotensin System in the Hallmarks of Cancer. In: Bhullar, S.K., Tappia, P.S., Dhalla, N.S. (eds) The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases. Advances in Biochemistry in Health and Disease, vol 25. Springer, Cham. https://doi.org/10.1007/978-3-031-23621-1_19
Download citation
DOI: https://doi.org/10.1007/978-3-031-23621-1_19
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-23620-4
Online ISBN: 978-3-031-23621-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)