Skip to main content

Inflammatory Myopathies

  • Chapter
  • First Online:
A Clinician's Pearls & Myths in Rheumatology

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aggarwal R, Lebiedz-Odrobina D, Sinha A, et al. Serum cardiac troponin T, but not troponin I, is elevated in idiopathic inflammatory myopathies. J Rheumatol. 2009;36(12):2711–4.

    CAS  PubMed  Google Scholar 

  • Aggarwal R, Cassidy E, Fertig N, et al. Patients with non-Jo-1 anti-tRNA-synthetase auto-antibodies have worse survival than Jo-1 positive patients. Ann Rheum Dis. 2014;73:227–32.

    PubMed  Google Scholar 

  • Aggarwal R, Dhillon N, Fertig N, et al. A negative antinuclear antibody does not indicate auto-antibody negativity in myositis: role of anticytoplasmic antibody as a screening test for antisynthetase syndrome. J Rheumatol. 2017a;44(2):223–9.

    CAS  PubMed  Google Scholar 

  • Aggarwal R, Rider LG, Ruperto N, et al. American College of Rheumatology/European League against rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: an International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative initiative. Ann Rheum Dis. 2017b;76(5):792–801.

    PubMed  Google Scholar 

  • Aggarwal R, Rider LG, Ruperto N, et al. 2016 American College of Rheumatology/European league against rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis. Arthritis Rheumatol. 2017c;69(5):898–910.

    PubMed  PubMed Central  Google Scholar 

  • Alexanderson H. Physical exercise as a treatment for adult and juvenile myositis. J Intern Med. 2016;280(1):75–96.

    CAS  PubMed  Google Scholar 

  • Basharat P, Lahouti AH, Paik JJ, Albayda J, Pinal-Fernandez I, Bichile T, Lloyd TE, Danoff SK, Casciola-Rosen L, Mammen AL, Christopher-Stine L. Statin-induced anti-HMGCR-associated myopathy. J Am Coll Cardiol. 2016;68(2):234–5.

    PubMed  PubMed Central  Google Scholar 

  • Bernet L, Lewis MA, Rieger KE, Casciola Rosen L, Fiorentino DF. Ovoid palatal patch in dermatomyositis: a novel finding associated with anti-TIF1γ (p155)auto-antibodies. JAMA Dermatol. 2016;152(9):1049–5.

    PubMed  PubMed Central  Google Scholar 

  • Betteridge Z, Tansley S, Shaddick G, et al. Frequency, mutual exclusivity and clinical associations of myositis auto-antibodies in a combined European cohort of idiopathic inflammatory myopathy patients. J Autoimmun. 2019;101:48–55.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bottai M, Tjarnlund A, Santoni G, et al. EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a methodology report. RMD Open. 2017;3(2):e000507.

    PubMed  PubMed Central  Google Scholar 

  • Cavagna L, Nuño L, Scirè CA. Serum Jo-1 autoantibody and isolated arthritis in the antisynthetase syndrome: review of the literature and report of the experience of AENEAS Collaborative Group. Clin Rev Allergy Immunol. 2017;52(1):71–80.

    CAS  PubMed  Google Scholar 

  • Chatterjee S, Prayson R, Farver C. Antisynthetase syndrome : not just an inflammatory myopathy. Cleve Clin J Med. 2013;80(10):655–66.

    PubMed  Google Scholar 

  • Chinoy H, Fertig N, Oddis CV, et al. The diagnostic utility of myositis auto-antibody testing for predicting the risk of cancer-associated myositis. Ann Rheum Dis. 2007;66:1345–9.

    PubMed  PubMed Central  Google Scholar 

  • Christopher-Stine L, Casciola-Rosen LA, Hong G, Chung T, Corse AM, Mammen AL. A novel auto-antibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum. 2010;62(9):2757–66.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dion E, Cherin P, Payan C, et al. Magnetic resonance imaging criteria for distinguishing between inclusion body myositis and polymyositis. J Rheumatol. 2002;29:1897.

    PubMed  Google Scholar 

  • Fiorentino D, Chung L, Zwerner J, Rosen R, Casciola-Rosen L. The mucocutaneous and systemic phenotype of dermatomyositis patients with auto-antibodies to MDA5 (CADM-140): a retrospective study. J Am Acad Dermatol. 2011;65(1):25–34.

    PubMed  PubMed Central  Google Scholar 

  • Fiorentino DF, Chung LS, Christopher-Stine L, et al. Most patients with cancer-associated dermatomyositis have auto-antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1γ. Arthritis Rheumatol. 2013;65(11):2954–62.

    CAS  Google Scholar 

  • Greenberg SA. Cytoplasmic 5′-nucleotidase auto-antibodies in inclusion body myositis: isotypes and diagnostic utility. Muscle Nerve. 2014;50(4):488–92.

    CAS  PubMed  Google Scholar 

  • Hengstman GJ, van Brenk L, Vree Egberts WT, et al. High specificity of myositis specific auto-antibodies for myositis compared with other neuromuscular disorders. J Neurol. 2005;252:534–7.

    CAS  PubMed  Google Scholar 

  • Hengstman GJ, ter Laak HJ, Vree Egberts WT, et al. Anti-signal recognition particle auto-antibodies: marker of a necrotising myopathy. Ann Rheum Dis. 2006;65:1635–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hill CL, Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A, Evans SR, Felson DT. Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet. 2001;357:96–100.

    CAS  PubMed  Google Scholar 

  • Hirakata M, Suwa A, Takada T, et al. Clinical and immunogenetic features of patients with auto-antibodies to asparaginyl-transfer RNA synthetase. Arthritis Rheum. 2007;56:1295–303.

    CAS  PubMed  Google Scholar 

  • Hull KM, Griffith L, Kuncl RW, Wigley FM. A deceptive case of amyloid myopathy: clinical and magnetic resonance imaging features. Arthritis Rheum. 2001;44(8):1954–8.

    CAS  PubMed  Google Scholar 

  • Ikenaga C, Findlay AR, Goyal NA, Robinson S, Cauchi J, Hussain Y, Wang LH, Kershen JC, Beson BA, Wallendorf M, Bucelli RC, Mozaffar T, Pestronk A, Weihl CC. Clinical utility of anti-cytosolic 5′-nucleotidase 1A antibody in idiopathic inflammatory myopathies. Clin Transl Neurol. 2021;8(3):571–8.

    CAS  Google Scholar 

  • Jablonska S, Blaszczyk M. Scleroderma overlap syndromes. Adv Exp Med Biol. 1999;455:85–92.

    CAS  PubMed  Google Scholar 

  • Kagen LJ, Aram S. Creatine kinase activity inhibitor in sera from patients with muscle disease. Arthritis Rheum. 1987;30:213–7.

    CAS  PubMed  Google Scholar 

  • Kao AH, Lacomis D, Lucas M, et al. Anti-signal recognition particle auto-antibody in patients with and patients without idiopathic inflammatory myopathy. Arthritis Rheum. 2004;50:209–15.

    CAS  PubMed  Google Scholar 

  • Kurtman DJB, Vleugels RA. Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: a concise review with an emphasis on distinctive clinical features. J Am Acad Dermatol. 2018;78(4):776–85.

    Google Scholar 

  • Larman HB, Salajegheh M, Nazareno R, et al. Cytosolic 5′-nucleotidase 1A autoimmunity in sporadic inclusion body myositis. Ann Neurol. 2013;73:408–18.

    PubMed  Google Scholar 

  • Lloyd TE, Christopher-Stine L, Pinal-Fernandez I, et al. Cytosolic 5′-Nucleotidase 1A as a target of circulating auto-antibodies in autoimmune diseases. Arthritis Care Res. 2016;68:66–71.

    CAS  Google Scholar 

  • Love LA, Leff RL, Fraser DD, et al. A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific auto-antibodies define useful homogeneous patient groups. Medicine. 1991;70:360–74.

    CAS  PubMed  Google Scholar 

  • Lundberg IE, Tjarnlund A, Bottai M, et al. 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Ann Rheum Dis. 2017;76:1955–64.

    PubMed  Google Scholar 

  • Mammen AL. Statin-associated autoimmune myopathy. N Engl J Med. 2016;374:664–9.

    CAS  PubMed  Google Scholar 

  • Mammen AL, Chung T, Christopher-Stine L, Rosen P, Rosen A, Doering KR, et al. Auto-antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 2011;63:713–21.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Mammen AL, Gaudet D, Brisson D, Christopher-Stine L, Lloyd TE, Leffell MS, et al. Increased frequency of DRB1*11:01 in anti-HMG-CoA reductase-associated autoimmune myopathy. Arthritis Care Res. 2012;64:1233–7.

    CAS  Google Scholar 

  • Mathur T, Manadan A, Thiagarajan S, et al. The utility of serum aldolase in normal creatine kinase dermatomyositis. J Clin Rheumatol. 2014;20(1):47–8.

    PubMed  Google Scholar 

  • Matsushita T, Hasegawa M, Fujimoto M, et al. Clinical evaluation of anti-aminoacyl tRNA synthetase auto-antibodies in Japanese patients with dermatomyositis. J Rheumatol. 2007;34:1012–8.

    CAS  PubMed  Google Scholar 

  • Mikuls T, MacLean C, Oliveri J, et al. Quality of care indicators for gout management. Arthritis Rheum. 2004;50(3):937–43.

    PubMed  Google Scholar 

  • Miller T, Al Lozi MT, Lopate G, et al. Myopathy with auto-antibodies to the signal recognition particle: clinical and pathological features. J Neurol Neurosurg Psychiatry. 2002;73:420–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Munters LA, Loell I, Ossipova E, et al. Endurance exercise improves molecular pathways of aerobic metabolism in patients with myositis. Arthritis Rheumatol. 2016;68(7):1738–50.

    CAS  PubMed  Google Scholar 

  • Oddis CV, Medsger TA Jr, Cooperstein LA. A subluxing arthropathy associated with the anti-Jo-1 antibody in polymyositis/dermatomyositis. Arthritis Rheum. 1990;33:1640–5.

    CAS  PubMed  Google Scholar 

  • Oddis CV, Okano Y, Rudert WA, et al. Serum auto-antibody to the nucleolar antigen PM-Scl: clinical and immunogenetic associations. Arthritis Rheum. 1992;35:1211–7.

    CAS  PubMed  Google Scholar 

  • Oh TH, Brumfield KA, Hoskin TL, et al. Dysphagia in inflammatory myopathy: clinical characteristics, treatment strategies, and outcome in 62 patients. Mayo Clin Proc. 2007;82:441–7.

    PubMed  Google Scholar 

  • Oldroyd AGS, Allard AB, Callen JP, et al. A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies. Rheumatology. 2021;60(6):2615–28.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Pinal-Fernandez I, Casal-Dominguez M, Carrino JA, et al. Thigh muscle MRI in immune-mediated necrotising myopathy: extensive oedema, early muscle damage and role of anti-SRP auto-antibodies as a marker of severity. Ann Rheum Dis. 2017;76(4):681–7.

    PubMed  Google Scholar 

  • Pluk H, van Hoeve BJ, van Dooren SH, et al. Auto-antibodies to cytosolic 5′-nucleotidase 1A in inclusion body myositis. Ann Neurol. 2013;73:397–407.

    CAS  PubMed  Google Scholar 

  • Quain RD, Teal V, Taylor L, et al. Number, characteristics, & classification of dermatomyositis patients seen by dermatology & rheumatology at a tertiary medical center. J Am Acad Dermatol. 2007;57:937–43.

    Google Scholar 

  • Rider LG, Giannini EH, Brunner HI, et al. International consensus on preliminary definitions of improvement in adult and juvenile myositis. Arthritis Rheum. 2004;50:2281–90.

    PubMed  Google Scholar 

  • Shovman O, Bentow C, Mahler M, et al. Anti-HMGCR auto-antibodies demonstrate high diagnostic value in the diagnosis of immune-mediated necrotizing myopathy following statin exposure. Immunol Res. 2017;65(1):276–81.

    CAS  PubMed  Google Scholar 

  • Tzaribachev N, Well C, Schedel J, Horger M. Whole-body MRI: a helpful diagnostic tool for juvenile dermatomyositis case report and review of the literature. Rheumatol Int. 2009;29(12):1511–4.

    PubMed  Google Scholar 

  • Villalba L, Hicks J, Adams E, et al. Treatment of refractory myositis: a randomized crossover study of two new cytotoxic regimens. Arthritis Rheum. 1998;41:392–9.

    CAS  PubMed  Google Scholar 

  • Voelker R. Cholesterol-lowering drugs taken by 28% of US population: news from centers of disease control and prevention. JAMA. 2015;313:787.

    Google Scholar 

  • Werner JL, Christopher-Stine L, Ghazarian SR, Pak KS, Kus JE, Daya NR, et al. Antibody levels correlate with creatine kinase levels and strength in anti-HMG-CoA reductase-associated autoimmune myopathy. Arthritis Rheum. 2012;64:4087–93.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wolstencroft PW, Casciola-Rosen L, Fiorentino DF. Association between auto-antibody phenotype and cutaneous adverse reactions to hydroxychloroquine in dermatomyositis. JAMA Dermatol. 2018;154(10):1199–20.

    PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chester Oddis .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Oddis, C., Limaye, V., Miller, F., Christopher-Stine, L. (2023). Inflammatory Myopathies. In: Stone, J.H. (eds) A Clinician's Pearls & Myths in Rheumatology. Springer, Cham. https://doi.org/10.1007/978-3-031-23488-0_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-23488-0_16

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-23487-3

  • Online ISBN: 978-3-031-23488-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics