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An Overview on Nanocarriers for Nasal Delivery

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Nasal Drug Delivery

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Abstract

Nasal delivery has come up as a promising approach to deliver diverse therapeutic agents including small drug molecules to biomacromolecules like peptides, proteins and genes to treat various disorders of central nervous system including depression, epilepsy, migraine, schizophrenia, Parkinson’s disease, Alzheimer’s disease, and brain tumor. Nasal route unveils the possibility for delivering the drug directly from nose to brain, circumventing the challenging blood-brain barrier enabling their effective brain delivery. The past couple of decades have witnessed tremendous enthusiasm about exploiting nanotechnology-based approaches in the drug delivery area, specifically due to the exponential growth in research efforts employing the nanocarriers’ delivery via different administration routes including the nasal route. Nanocarrier-based nasal delivery of drugs has progressed over the years with an assumption that the use of nanocarriers would enable the drug to access tissues and organs that could otherwise not be accessed effectively by conventional nasal delivery. The present chapter sets out to discuss applications of different nanocarriers in nasal delivery along with their transportation mechanisms and toxicity concerns.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico – Medical Sciences Campus, San Juan, PR, USA

    Sunita Dahiya

  2. School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago

    Rajiv Dahiya

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  1. Sunita Dahiya
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  1. Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V. Pathak

  2. School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India

    Hemant K. S. Yadav

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Dahiya, S., Dahiya, R. (2023). An Overview on Nanocarriers for Nasal Delivery. In: Pathak, Y.V., Yadav, H.K.S. (eds) Nasal Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-031-23112-4_9

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