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Factors Affecting the Design of Nasal Drug Delivery System

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Nasal Drug Delivery

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Abstract

Over the recent years, many strategies have improved the delivery of bioactive agents to the brain, improving the treatment of several pathologies. Nonetheless, the design of new formulations is highly dependent on the capacity of the drugs to permeate the blood-brain barrier (BBB) and reach a significant effect on the neurological disorders. Therefore, different approaches have been studied in order to facilitate the delivery of different drugs into the brain; for instance, intranasal administration has gained special interest. The nose-to-brain delivery provides a direct pathway of drug delivery to the brain without the need to permeate the BBB, potentially avoiding adverse effects that could occur when the drug is systemically absorbed. Although it may overcome BBB, there are alternative barriers that have to be circumvented for nose-to-brain route and different strategies have been massively studied. This chapter provides a comprehensive overview of factors related to the physiology of nasal cavity, the drug, and the formulation that can affect the development of formulations for nose-to-brain drug delivery.

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Authors and Affiliations

  1. Department of Pharmacy, State University of Maringa, Maringa, PR, Brazil

    Jéssica Bassi da Silva, Maria Vitoria Gouveia Botan & Marcos Luciano Bruschi

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  1. Jéssica Bassi da Silva
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  2. Maria Vitoria Gouveia Botan
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  3. Marcos Luciano Bruschi
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Correspondence to Marcos Luciano Bruschi .

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Editors and Affiliations

  1. Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V. Pathak

  2. School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India

    Hemant K. S. Yadav

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da Silva, J.B., Botan, M.V.G., Bruschi, M.L. (2023). Factors Affecting the Design of Nasal Drug Delivery System. In: Pathak, Y.V., Yadav, H.K.S. (eds) Nasal Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-031-23112-4_4

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