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Circulating Tumor Cells (CTC) and Tumor-Derived Extracellular Vesicles (tdEV)

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Circulating Tumor Cells

Part of the book series: Current Cancer Research ((CUCR))

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Abstract

The observation that increasing circulating tumor cell (CTC) and tumor-derived extracellular vesicle (tdEV) load is directly related to worse clinical outcome of cancer patients is in line with expectations. However, both CTC and tdEV exhibit inter- and intra-patient heterogeneity, and the puzzle is yet to be deciphered in regard to the phenotype of CTC or tdEV that can predict prognosis and response to therapy or an effective treatment. A large variety of different approaches to identify CTC and tdEV have emerged over the last two decades, some of which have been evaluated in the clinic, whereas others not. In the second case, we can just speculate what is the output of these techniques and how it is translated to better understand the metastatic process and guide cancer patient care more effectively. Here, we will review what we have learned from CTC and tdEV identified by the CellSearch system and discuss our initial attempts to further characterize tdEV and explore their potential.

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Acknowledgments

This work was supported by the Netherlands Organization for Scientific Research Perspectief CANCER-ID 14198.

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Authors and Affiliations

  1. Department of Medical Cell BioPhysics, University of Twente, Enschede, The Netherlands

    A. Nanou & L. W. M. M. Terstappen

  2. Department of AMBER, University of Twente, Enschede, The Netherlands

    P. Beekman

  3. Department of BioElectric signaling and Engineering, University of Twente, Enschede, The Netherlands

    A. Enciso Martinez

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Correspondence to L. W. M. M. Terstappen .

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  1. Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA

    Richard J. Cote

  2. ACTC Lab, Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece

    Evi Lianidou

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Nanou, A., Beekman, P., Enciso Martinez, A., Terstappen, L.W.M.M. (2023). Circulating Tumor Cells (CTC) and Tumor-Derived Extracellular Vesicles (tdEV). In: Cote, R.J., Lianidou, E. (eds) Circulating Tumor Cells. Current Cancer Research. Springer, Cham. https://doi.org/10.1007/978-3-031-22903-9_6

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